946598-99-8

Basic information

• Product Name: trans-ethyl 2-(4-acetamidocyclohexyl)acetate
• Synonyms: trans-ethyl 2-(4-acetamidocyclohexyl)acetate
• CAS NO: 946598-99-8
• Molecular Weight: 227.304
• Mol File: 946598-99-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: trans-ethyl 2-(4-acetamidocyclohexyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: trans-ethyl 2-(4-acetamidocyclohexyl)acetate(946598-99-8)
• EPA Substance Registry System: trans-ethyl 2-(4-acetamidocyclohexyl)acetate(946598-99-8)

Safety Data

• Hazardous Substances Data: 946598-99-8(Hazardous Substances Data)

Upstream product

• 90978-94-2 Actarit 
• 64-17-5 ethanol 
• 2901-44-2 trans-2-(4-acetamidocyclohexyl)acetic acid 
• 27514-08-5 N-(4-oxocyclohexyl)acetamide 
• 75-36-5 acetyl chloride 
• 76308-26-4 ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride 
• 18699-02-0 4-acetamidophenylacetic acid 

Relevant articles and documents

Synthesis and biological evaluation of novel antipsychotic trans-4-(2-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)ethyl)cyclohexan-1-amine derivatives targeting dopamine/serotonin receptor subtypes

In this study, a series of trans-4-(2-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)ethyl)cyclohexan-1-amine derivatives as potential antipsychotics were synthesized and biologically evaluated to discover potential antipsychotics with good drug target selectivity. The preliminary structure-activity relationship was discussed, and optimal compound 12a showed both nanomolar affinity for D2/D3/5-HT1A/5-HT2A receptors and weak α1 and H1 receptor binding affinity. In addition, 12a was metabolically stable in vitro, displayed micromolar affinity for the hERG channel, and exhibited antipsychotic efficacy in the animal model of locomotor-stimulating effects of phencyclidine.

BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS

The present invention relates to compounds of formula (I) wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general formula (I) have high affinity for the dopamine D3 and serotonin (5-Hydroxytryptamine; 5-HT) 5-HT2A receptors and are effective in the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.