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Cas Database

947607-17-2

947607-17-2

947607-17-2

Identification

Synonyms:4-(4-pyrimidin-2-yl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Properties

Safety information and MSDS

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Relevant articles and documentsAll total 1 Articles be found

PYRROLIDINE DERIVATIVES AS ERK INHIBITORS

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Page/Page column 194, (2010/11/28)

Disclosed are the ERK inhibitors of Formula (1.0): and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of Formula (1.0).

Process route upstream and downstream products

Process route

4-(4-Bromophenyl)amino-1-(tert-butoxycarbonyl)piperidine
443998-65-0

4-(4-Bromophenyl)amino-1-(tert-butoxycarbonyl)piperidine

2-(tributylstannyl)pyrimidine
153435-63-3

2-(tributylstannyl)pyrimidine

4-(4-pyrimidin-2-yl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester
947607-17-2

4-(4-pyrimidin-2-yl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester

Conditions
Conditions Yield
bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 100 ℃;
31%
4-(4-pyrimidin-2-yl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester
947607-17-2

4-(4-pyrimidin-2-yl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester

piperidin-4-yl-(4-pyrimidin-2-yl-phenyl)-amine hydrochloride
947607-18-3

piperidin-4-yl-(4-pyrimidin-2-yl-phenyl)-amine hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

947607-17-2 Upstream products

947607-17-2 Downstream products

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