949-01-9Relevant articles and documents
Desulfurizing agent for thioamides
Polushina,Zavarzin,Krayushkin,Rodionova,Yarovenko
, p. 383 - 385 (2021/03/03)
Thioamides treated with thionyl chloride in an ionic liquid were successfully converted into amides.
Method for synthesizing thioamide compound from 1,2,3-thiodiazole compound and amine under catalysis of copper
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Paragraph 0168-0174, (2021/05/12)
The invention belongs to the technical field of organic chemistry, and discloses a method for synthesizing a thioamide compound from a 1,2,3-thiodiazole compound and amine under the catalysis of copper. The method comprises the following steps: in a protective atmosphere, taking an organic solvent as a reaction medium, reacting a 1,2,3-thiodiazole compound with an amine compound under the action of a copper salt catalyst or a copper catalyst and a phosphine ligand, and carrying out subsequent treatment to obtain the thioamide compound. According to the method, the copper salt is used as the catalyst, the phosphine ligand is adopted, the yield is high, and the substrate applicability is wide. In addition, the reaction takes the 1,2,3-thiodiazole compound and the amine compound as raw materials, and has the advantages that the raw materials are cheap and easy to prepare, the operation is simple and convenient, and the atom economy is high.
Transition-Metal-Free Cleavage of C-C Triple Bonds in Aromatic Alkynes with S8 and Amides Leading to Aryl Thioamides
Xu, Kai,Li, Ziyi,Cheng, Fangyuan,Zuo, Zhenzhen,Wang, Tao,Wang, Mincan,Liu, Lantao
supporting information, p. 2228 - 2231 (2018/04/30)
A novel transition-metal-free cleavage reaction of C-C triple bonds in aromatic alkynes with S8 and amides furnishes aryl thioamides in moderate to excellent yields. The remarkable features of this thioamidation include the metal-free cleavage of C-C triple bond, mild reaction conditions, as well as wide substrate scope that is particularly compatible with some internal aromatic alkynes and acetamides.