94905-71-2

Basic information

• Product Name: (E)-N-(3-(3-(benzo[d][1,3]dioxol-5-yl)acryloyl)-4-hydroxyphenyl)acetamide
• Synonyms: (E)-N-(3-(3-(benzo[d][1,3]dioxol-5-yl)acryloyl)-4-hydroxyphenyl)acetamide
• CAS NO: 94905-71-2
• Molecular Weight: 325.321
• Mol File: 94905-71-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-N-(3-(3-(benzo[d][1,3]dioxol-5-yl)acryloyl)-4-hydroxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(3-(3-(benzo[d][1,3]dioxol-5-yl)acryloyl)-4-hydroxyphenyl)acetamide(94905-71-2)
• EPA Substance Registry System: (E)-N-(3-(3-(benzo[d][1,3]dioxol-5-yl)acryloyl)-4-hydroxyphenyl)acetamide(94905-71-2)

Safety Data

• Hazardous Substances Data: 94905-71-2(Hazardous Substances Data)

Upstream product

• 120-57-0 piperonal 
• 7298-67-1 5-acetamido-2-hydroxyacetophenone 
• 103-90-2 4-acetaminophenol 

Relevant articles and documents

Selected novel 5’-amino-2’-hydroxy-1, 3-diaryl-2- propen-1-ones arrest cell cycle of HCT-116 in G0/G1 phase

A series of 5’-amino-2’-hydroxy-1,3-diaryl-2-propen-1-ones (AC1-AC15) were synthesized by Claisen-Schmidt condensation of 5'-acetamido-2’-hydroxy acetophenone with various substituted aromatic aldehydes. The syn- thesized compounds were characterized by FTIR, 1H NMR and mass spectrometry and evaluated for their selec- tive cytotoxicity using MTT assay on two cancer cell lines namely breast cancer cell line (MCF-7), colon cancer cell line (HCT-116) and one normal kidney epithelial cell line (Vero). Among the tested compounds, AC-10 showed maximum cytotoxic effect on MCF-7 cell line with IC50 value 74.7 ± 3.5 μM. On HCT-116 cells, AC-13 exhibited maximum cytotoxicity with IC50 value 42.1 ± 4.0 μM followed by AC-14 and AC-10 with IC50 values 62 ± 2.3 μM and 95.4 ± 1.7 μM respectively. All tested compounds were found to be safe on Vero cell line with IC50 value more than 200 μM. Based on their highest efficacy on HCT-116, AC-10, AC-13 and AC-14 were selected for mechanistic study on this cell line by evaluating changes nucleomorphological characteristics using acridine orange-ethidium bromide (AOEB) dual stain and by analyzing cell cycle with flow cytometry using propidium iodide stain. In AOEB staining, all three tested compounds showed significant (p 0/G1 phase and by AC-13 in G0/G1 and G2/M phase. The study reflected the potential of AC-10, AC-13 and AC-14 to be the lead molecules for further optimization.

CDK inhibitors having flavone structure

The present invention relates to a novel flavone derivative, pharmaceutically acceptable salt, hydrate, solvate and isomer thereof which is useful as an inhibitor against Cyclin Dependent Kinase (CDK), a process for preparation thereof, and a composition of anti-cancer agent or agent for treating neurodegenerative disease comprising this compound as an active ingredient.