949090-28-2

Basic information

• Product Name: 3-fluoro-4-methoxymethoxybenzaldehyde
• Synonyms: 3-fluoro-4-methoxymethoxybenzaldehyde
• CAS NO: 949090-28-2
• Molecular Weight: 184.167
• Mol File: 949090-28-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-fluoro-4-methoxymethoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-4-methoxymethoxybenzaldehyde(949090-28-2)
• EPA Substance Registry System: 3-fluoro-4-methoxymethoxybenzaldehyde(949090-28-2)

Safety Data

• Hazardous Substances Data: 949090-28-2(Hazardous Substances Data)

Upstream product

• 405-05-0 3-fluoro-4-hydroxybenzaldehyde 
• 107-30-2 chloromethyl methyl ether 
• 13057-17-5 bromethyl methyl ether 

Downstream Products

• 1020399-80-7 C₂₁H₂₀F₂O₅ 
• 1369768-86-4 {(1R,2S)-2-[3-fluoro-4-(methoxymethoxy)phenyl]-2-(hydroxymethyl)cyclopropyl}methyl acetate 
• 1369768-84-2 (1S,5R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]-3-oxabicyclo[3.1.0]hexan-2-one 
• 1369768-91-1 (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropanecarboxylic acid 
• 1369768-90-0 (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropanecarbaldehyde 
• 1369768-87-5 {(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropyl}methanol 
• 1369768-85-3 (1S,2R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropane-1,2-dimethanol 
• 1369768-83-1 2-[3-fluoro-4-(methoxymethoxy)phenyl]acetonitrile 

Relevant articles and documents

Scalable Total Synthesis of (+)- And (-)-Codonopiloneolignanin A via Ti(IV)/NHC Cooperative Control Highly Enantioselective Dimerization of Multisubstituted Cinnamaldehyde

The first gram-scale asymmetric total synthesis of (+)- and (-)-codonopiloneolignanin A has been achieved from multisubstituted cinnamaldehyde in four steps with 37% overall yield. The synthetically challenging tricyclic [5, 3, 0, 03,8] decane skeleton was efficiently constructed via a highly enantioselective dimerization of multisubstituted cinnamaldehyde, followed by a sequence of cascade reactions including Prins cyclization, cation mediated cyclization, and deprotection. Furthermore, the scope of NHC-catalyzed/Ti(IV)-mediated synergistic control multisubstituted cinnamaldehyde dimerization was investigated. Significantly, the bioactivity of codonopiloneolignanin A and its enantiomer, particularly scarce in nature, was tested and showed good anticancer activity.

CYCLOPROPANE COMPOUND

A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: wherein Q represents —CH— or a nitrogen atom, R1a and R1b each independently represent a C1-6 alkyl group and the like, R1c represents a hydrogen atom and the like, R2a, R2b, R2c and R2d each independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group and the like, R3a, R3b and R3c each independently represent a hydrogen atom, a halogen atom and the like, and R3d represents a hydrogen atom and the like.