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95-48-7

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95-48-7 Usage

General Description

o-Cresol, also known as ortho-cresol, is a type of phenol. It is an organic compound with the molecular formula CH3C6H4OH. A derivative of phenol, o-Cresol is a colorless liquid with a strong smell and is slightly soluble in water, but is miscible with many organic solvents, including ethanol. It can be found naturally in coal tar and creosote oils and is usually obtained from these sources industrially. It is widely used as a raw material or intermediate in a variety of chemical industries, such as the production of antioxidants, fragrances, dyes, and certain pharmaceuticals. However, exposure to o-Cresol can cause harm to the skin, eyes, or respiratory tract, and it is therefore classified as a hazardous substance.

Check Digit Verification of cas no

The CAS Registry Mumber 95-48-7 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 95-48:
(4*9)+(3*5)+(2*4)+(1*8)=67
67 % 10 = 7
So 95-48-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H8O/c1-6-4-2-3-5-7(6)8/h2-5,8H,1H3

95-48-7 Well-known Company Product Price

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  • Alfa Aesar

  • (A12307)  o-Cresol, 98+%   

  • 95-48-7

  • 500g

  • 273.0CNY

  • Detail
  • Alfa Aesar

  • (A12307)  o-Cresol, 98+%   

  • 95-48-7

  • 2500g

  • 833.0CNY

  • Detail
  • Alfa Aesar

  • (A12307)  o-Cresol, 98+%   

  • 95-48-7

  • 2000g

  • 1041.0CNY

  • Detail
  • Alfa Aesar

  • (A12307)  o-Cresol, 98+%   

  • 95-48-7

  • 10000g

  • 2759.0CNY

  • Detail
  • Sigma-Aldrich

  • (36922)  o-Cresol  analytical standard

  • 95-48-7

  • 36922-250MG

  • 217.62CNY

  • Detail
  • Supelco

  • (442361)  2-Methylphenol  analytical standard

  • 95-48-7

  • 000000000000442361

  • 234.00CNY

  • Detail

95-48-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name o-cresol

1.2 Other means of identification

Product number -
Other names o-toluol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:95-48-7 SDS

95-48-7Synthetic route

(2-methylphenoxy)trimethylsilane
1009-02-5

(2-methylphenoxy)trimethylsilane

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
montmorillonite K-10 for 0.0166667h; Solid phase reaction; desilylation; microwave irradiation;100%
With Nanoporous Na+-Montmorillonite Perchloric Acid In ethanol at 20℃; for 0.0833333h;90%
With hydrogenchloride In methanol Ambient temperature; Yield given;
o-Tolyl N,N,N',N'-tetramethylphosphorodiamidate
56184-99-7

o-Tolyl N,N,N',N'-tetramethylphosphorodiamidate

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With formic acid for 1h; Product distribution; Heating;100%
In formic acid for 1h; Heating; Yield given;
2-Methylphenylboronic acid
16419-60-6

2-Methylphenylboronic acid

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With 3,3'-dihexyloxy-1,1'-binaphthylidene-4,4'-dione; potassium hydroxide In tetrahydrofuran; water at 20℃;100%
With dihydrogen peroxide at 20℃; for 0.25h; Green chemistry;98%
With water; oxygen; sodium sulfite at 50℃; for 1h; Green chemistry;97%
salicylaldehyde
90-02-8

salicylaldehyde

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With hydrogen In para-xylene at 120℃; under 750.075 Torr; for 24h; Glovebox; Sealed tube; chemoselective reaction;99%
With formic acid; C18H14ClN4O2Ru(1+)*Cl(1-); sodium formate In water at 80℃; for 32h; Inert atmosphere;70%
With acetic acid; zinc In ethanol at 180℃; for 0.25h; Solvent; Temperature; Microwave irradiation;56%
2-Methylcyclohexanol
583-59-5

2-Methylcyclohexanol

A

ortho-cresol
95-48-7

ortho-cresol

B

toluene
108-88-3

toluene

Conditions
ConditionsYield
platinum; potassium oxide at 360℃;A 98%
B 2%
platinum; potassium oxide at 360℃; Product distribution; other content of catalyst;A 98%
B 2%
2-methylphenyl acetate
533-18-6

2-methylphenyl acetate

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With sodium tetrahydroborate; cobalt(II) chloride In ethanol at 0 - 25℃; for 10h;98%
ortho-dimethylaminomethylphenol
120-65-0

ortho-dimethylaminomethylphenol

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With hydrogen; nickel-titanium-aluminum In various solvent(s) at 160℃; for 3h;97.8%
With hydrogen; nickel-titanium-aluminum In various solvent(s) at 160℃; for 3h; Product distribution; Rate constant; Thermodynamic data; other temperatures;97.8%
ortho-methylphenyl iodide
615-37-2

ortho-methylphenyl iodide

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With glycolic Acid; copper hydroxide; sodium hydroxide In water; dimethyl sulfoxide at 120℃; for 6h; Inert atmosphere; Schlenk technique;97%
With copper(l) iodide; 8-quinolinol; potassium hydroxide In water; dimethyl sulfoxide; tert-butyl alcohol at 100℃; for 48h; Inert atmosphere;96%
Stage #1: ortho-methylphenyl iodide With copper(l) iodide; 8-Hydroxyquinoline-N-oxide In dimethyl sulfoxide at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: With cesiumhydroxide monohydrate In water; dimethyl sulfoxide at 100℃; for 24h; Inert atmosphere;
95%
1,1-dimethylethyl 2-methylphenyl carbonate
95932-31-3

1,1-dimethylethyl 2-methylphenyl carbonate

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With erbium(III) triflate In ethanol for 25h; Microwave irradiation;97%
2-hydroxy-3-methylphenyl boronic acid
259209-22-8

2-hydroxy-3-methylphenyl boronic acid

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
In dimethyl sulfoxide at 120℃; for 24h;96%
2-(tert-butyldimethylsilyloxy)toluene
62790-79-8

2-(tert-butyldimethylsilyloxy)toluene

Cs2CO3

Cs2CO3

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
In water; N,N-dimethyl-formamide at 20℃; for 3h;95%
2-Methylphenylboronic acid
16419-60-6

2-Methylphenylboronic acid

dihydrogen peroxide
7722-84-1

dihydrogen peroxide

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With ammonium bicarbonate In water at 20℃; for 2h; Schlenk technique;95%
C7H7N2O(1+)*BF4(1-)

C7H7N2O(1+)*BF4(1-)

A

4-fluoro-2-methylphenol
452-72-2

4-fluoro-2-methylphenol

B

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With pyridine; hydrogen fluoride for 1.66667h; Decomposition; Fluoro-dediazoniation; Irradiation;A 93.8%
B 1.1%
2-methylphenyl bromide
95-46-5

2-methylphenyl bromide

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
Stage #1: 2-methylphenyl bromide With potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); 2-((di-adamantan-1-yl)phosphaneyl)-1-(2,6-diisopropylphenyl)-1H-imidazole In 1,4-dioxane; water at 100℃; for 20h; Inert atmosphere;
Stage #2: With hydrogenchloride In 1,4-dioxane; water at 20℃; Inert atmosphere;
93%
With cesiumhydroxide monohydrate; bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II); 2-((di-adamantan-1-yl)phosphaneyl)-1-(2,6-diisopropylphenyl)-1H-imidazole In tetrahydrofuran at 24℃; for 20h; Inert atmosphere;92%
Stage #1: 2-methylphenyl bromide With copper(l) iodide; 8-Hydroxyquinoline-N-oxide In dimethyl sulfoxide at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: With cesiumhydroxide monohydrate In water; dimethyl sulfoxide at 110℃; for 18h; Inert atmosphere;
90%
2-(tert-butyldimethylsilyloxy)toluene
62790-79-8

2-(tert-butyldimethylsilyloxy)toluene

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 20℃; for 1.6h;93%
With zinc tetrafluoroborate In water for 24h; Heating;88%
With sodium cyanide In ethanol; water at 80℃; for 15h; chemoselective reaction;84.5%
With sodium phosphate dodecahydrate In N,N-dimethyl-formamide at 20℃; for 2.5h;83%
2-methylchlorobenzene
95-49-8

2-methylchlorobenzene

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With cesiumhydroxide monohydrate; bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II); 2-((di-adamantan-1-yl)phosphaneyl)-1-(2,6-diisopropylphenyl)-1H-imidazole In tetrahydrofuran at 24℃; for 20h; Inert atmosphere;92%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; tris-(dibenzylideneacetone)dipalladium(0); cesiumhydroxide monohydrate In tetrahydrofuran at 24℃; Inert atmosphere; Glovebox; Sealed tube;91%
With aluminum (III) chloride; choline chloride; urea; sodium hydroxide at 180℃; for 6h; Reagent/catalyst; Green chemistry;86.2%
With trans-di(μ-acetato)bis[o-(di-o-tolyl-phosphino)benzyl]dipalladium(II); C29H45Pt; potassium carbonate In water; N,N-dimethyl-formamide at 115℃; for 0.5h; Inert atmosphere; Microwave irradiation;63%
5-hydroxy-2-methyl-2-cyclohexenone

5-hydroxy-2-methyl-2-cyclohexenone

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene at 70℃;91%
3,3-diethyl-1-(o-tolyl)triaz-1-ene
36719-44-5

3,3-diethyl-1-(o-tolyl)triaz-1-ene

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With water; sulfonic acid resin (H+ form) In acetonitrile for 0.166667h; Heating;90%
methyl 2-methylphenoxy acetate
2989-17-5

methyl 2-methylphenoxy acetate

A

o-methylphenoxyacetic acid
1878-49-5

o-methylphenoxyacetic acid

B

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With lithium chloride In N,N-dimethyl-formamide for 22h; Heating;A 90%
B 5%
dimethyl(2-methylphenyl)isopropoxysilane

dimethyl(2-methylphenyl)isopropoxysilane

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium hydrogencarbonate In tetrahydrofuran; methanol; water at 20℃; for 16h; Inert atmosphere;90%
allyl o-tolyl ether
936-72-1

allyl o-tolyl ether

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With iodine at 20℃;89%
2-methylphenyl aldehyde
529-20-4

2-methylphenyl aldehyde

A

ortho-methylbenzoic acid
118-90-1

ortho-methylbenzoic acid

B

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With selenium(IV) oxide; dihydrogen peroxide In tetrahydrofuran for 10h; Heating;A 88%
B 9 % Chromat.
With dihydrogen peroxide; methyltrioctylammonium tetrakis(oxodiperoxotungsto)phosphate at 90℃; for 1.5h;A 23%
B 10%
methanol
67-56-1

methanol

phenol
108-95-2

phenol

A

2.6-dimethylphenol
576-26-1

2.6-dimethylphenol

B

methoxybenzene
100-66-3

methoxybenzene

C

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
zirconium(IV) oxide at 320℃; under 112509 Torr; for 1.5h; Product distribution; Kinetics; Further Variations:; Catalysts; Pressures; Temperatures;A 87%
B 0.5%
C 6%
aluminum oxide at 290℃; under 195.02 - 600.05 Torr; Kinetics; Product distribution; Rate constant;
samarium(III) oxide; tin(IV) oxide at 349.85℃; for 1h; Product distribution; Further Variations:; Catalysts; Alkylation;
2-methylmethoxybenzene
578-58-5

2-methylmethoxybenzene

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With trimethylsilyl iodide at 105 - 114℃; for 0.25h; Microwave irradiation; Inert atmosphere;85%
With pyridine hydrochloride for 0.233333h; demethylation; microwave irradiation;82%
With pyridinium p-toluenesulfonate for 0.0333333h; microwave irradiation;70%
With boron tribromide-dimethyl sulfide complex In 1,2-dichloro-ethane at 83.5℃; for 12h;67.2%
With hydrogen In dodecane; hexane at 270℃; under 22502.3 Torr; for 8h; Autoclave;
cyclohexenone
930-68-7

cyclohexenone

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With dipotassium peroxodisulfate; iron(III) chloride hexahydrate at 110℃; for 4h; Sealed tube;84%
o-toluidine
95-53-4

o-toluidine

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
Stage #1: o-toluidine With sulfuric acid at 20℃; Cooling with ice;
Stage #2: With sodium nitrite In water Reflux;
83%
Stage #1: o-toluidine With sodium nitrite In water at 20℃; Milling; Green chemistry;
Stage #2: With water at 60℃; for 0.416667h; Neutral conditions; Green chemistry;
78%
With sulfuric acid Diazotization.Verkochen des Diazoniumsulfats mit Wasser;
chromane
493-08-3

chromane

A

ethene
74-85-1

ethene

B

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With hydrogen In toluene at 629.9℃; Mechanism; Kinetics; Rate constant; other temperature 760-1110 K;A n/a
B 83%
1-(but-3-en-1-yloxy)-2-methylbenzene

1-(but-3-en-1-yloxy)-2-methylbenzene

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With 6,6'-dimethyl-2,2'-bipyridine; (1,2-dimethoxyethane)dichloronickel(II); bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide; water at 30℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;83%
With [2,2]bipyridinyl; (1,2-dimethoxyethane)dichloronickel(II); water; bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide at 30℃; for 24h; Schlenk technique;63%
acetic anhydride
108-24-7

acetic anhydride

ortho-cresol
95-48-7

ortho-cresol

2-methylphenyl acetate
533-18-6

2-methylphenyl acetate

Conditions
ConditionsYield
at 20℃; for 0.666667h;100%
With triethylamine In dichloromethane at 20℃;99%
With silver trifluoromethanesulfonate at 60℃; for 0.116667h; neat (no solvent);99%
ortho-cresol
95-48-7

ortho-cresol

4-Bromo-2-methylphenol
2362-12-1

4-Bromo-2-methylphenol

Conditions
ConditionsYield
With benzyltriphenylphosphonium peroxodisulfate; potassium bromide In acetonitrile for 4.5h; Heating;100%
With dihydrogen peroxide; vanadia; potassium bromide In chloroform; water at 24.84℃; under 760.051 Torr;99%
With hydrogen bromide; acetic acid In water; dimethyl sulfoxide at 20℃; for 16h;99%
ortho-cresol
95-48-7

ortho-cresol

2-methyl-4,6-dinitrophenol
534-52-1

2-methyl-4,6-dinitrophenol

Conditions
ConditionsYield
With (NH4)2Ce(NO3)6 on pillared bentonite In methanol at 25℃; for 48h;100%
With thionyl chloride; bismuth subnitrate In dichloromethane at 20℃; for 2h;83%
With cupric nitrate trihydrate supported on K 10 montmorillonite clay; nitric acid; acetic anhydride In tetrachloromethane for 1h; Ambient temperature;80%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

ortho-cresol
95-48-7

ortho-cresol

2-methylphenyl methanesulfonate
1009-01-4

2-methylphenyl methanesulfonate

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 0 - 20℃; for 0.166667h; Green chemistry;100%
With triethylamine In dichloromethane at 0 - 20℃;89%
With pyridine85%
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;74%
With pyridine
ortho-cresol
95-48-7

ortho-cresol

propargyl bromide
106-96-7

propargyl bromide

1-methyl-2-(2-propynyloxy)benzene
5652-20-0

1-methyl-2-(2-propynyloxy)benzene

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran100%
With potassium carbonate In acetone Reflux;100%
Stage #1: ortho-cresol With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 0.5h; Inert atmosphere;
Stage #2: propargyl bromide In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
90%
bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

ortho-cresol
95-48-7

ortho-cresol

methyl 2-methylphenoxy acetate
2989-17-5

methyl 2-methylphenoxy acetate

Conditions
ConditionsYield
With potassium carbonate In butanone for 5.5h; Heating;100%
With potassium carbonate In acetone Ambient temperature;100%
With caesium carbonate In acetonitrile at 25℃;
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;
methyl 3,3,3-trifluoropyruvate
13089-11-7

methyl 3,3,3-trifluoropyruvate

ortho-cresol
95-48-7

ortho-cresol

4-(1-hydroxy-1-methoxycarbonyl-2,2,2-trifluoroethyl)-2-methylphenol

4-(1-hydroxy-1-methoxycarbonyl-2,2,2-trifluoroethyl)-2-methylphenol

Conditions
ConditionsYield
With triethylamine In tetrachloromethane for 24h; Ambient temperature;100%
With tert-butylamine In tetrachloromethane for 3h; Ambient temperature; other substituted phenols, other polyfluorinated carbonyl compounds, other amines and solvents; nucleophilic catalysis in C-hydroxyalkylation;
triethyl orthoacrylate
42216-96-6

triethyl orthoacrylate

ortho-cresol
95-48-7

ortho-cresol

2,2-diethoxy-8-methylchroman
80515-78-2

2,2-diethoxy-8-methylchroman

Conditions
ConditionsYield
With Trimethylacetic acid In toluene for 20h; Heating;100%
ortho-cresol
95-48-7

ortho-cresol

Ethyl 2-bromopropionate
535-11-5, 41978-69-2

Ethyl 2-bromopropionate

ethyl 2-(2-methylphenyl)oxypropionate
128760-23-6

ethyl 2-(2-methylphenyl)oxypropionate

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide100%
With potassium iodide In N,N-dimethyl-formamide; acetone Heating;83%
chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

ortho-cresol
95-48-7

ortho-cresol

1-methoxymethoxy-2-methylbenzene
55359-65-4

1-methoxymethoxy-2-methylbenzene

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Etherification;100%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; for 16h;99%
Stage #1: ortho-cresol With N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane for 0.166667h;
Stage #2: chloromethyl methyl ether In 1,2-dichloro-ethane at 20℃; for 10h;
98%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

ortho-cresol
95-48-7

ortho-cresol

2-(tert-butyldimethylsilyloxy)toluene
62790-79-8

2-(tert-butyldimethylsilyloxy)toluene

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide for 3h;100%
With 1H-imidazole In N,N-dimethyl-formamide at 23℃; for 15h; Inert atmosphere; Schlenk technique;99%
With 1H-imidazole; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 20℃; for 2h;98%
ortho-cresol
95-48-7

ortho-cresol

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

1-methyl-2-(2-nitrophenoxy)benzene
54106-40-0

1-methyl-2-(2-nitrophenoxy)benzene

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 95℃; for 20h;100%
Stage #1: ortho-cresol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;
Stage #2: ortho-nitrofluorobenzene In N,N-dimethyl-formamide at 20 - 50℃; for 13h; Inert atmosphere;
93%
Stage #1: ortho-cresol With potassium tert-butylate In tetrahydrofuran for 1h;
Stage #2: ortho-nitrofluorobenzene In tetrahydrofuran
2-Iodobenzyl bromide
40400-13-3

2-Iodobenzyl bromide

ortho-cresol
95-48-7

ortho-cresol

2-(2-iodobenzyloxy)-1-toluene

2-(2-iodobenzyloxy)-1-toluene

Conditions
ConditionsYield
With potassium carbonate In acetone at 50℃;100%
In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate59.1 g (94%)
In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate59.1 g (94%)
1-(tert-Butoxycarbonyl)-4-cyano-4-(methanesulfonyloxymethyl)piperidine
614729-57-6

1-(tert-Butoxycarbonyl)-4-cyano-4-(methanesulfonyloxymethyl)piperidine

ortho-cresol
95-48-7

ortho-cresol

1-(tert-Butoxycarbonyl)-4-cyano-4-(2-methylphenoxymethyl)piperidine
614729-60-1

1-(tert-Butoxycarbonyl)-4-cyano-4-(2-methylphenoxymethyl)piperidine

Conditions
ConditionsYield
In water; ethyl acetate; N,N-dimethyl-formamide100%
(4R)-1,2,3-oxathiazolidine-3-carboxylic acid, 4-phenyl 1,1-dimethylethyl ester-2,2-dioxide
1209467-60-6

(4R)-1,2,3-oxathiazolidine-3-carboxylic acid, 4-phenyl 1,1-dimethylethyl ester-2,2-dioxide

ortho-cresol
95-48-7

ortho-cresol

R-(-)-α-[(2-methylphenoxy)methyl]benzenemethanamine

R-(-)-α-[(2-methylphenoxy)methyl]benzenemethanamine

Conditions
ConditionsYield
Stage #1: tert-butyl (R)-4-phenyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide; ortho-cresol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 2h; Inert atmosphere;
Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 3h; optical yield given as %ee; enantioselective reaction;
100%
cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

ortho-cresol
95-48-7

ortho-cresol

3-(2-methylphenoxy)-3-oxo-propanoic acid
114223-12-0

3-(2-methylphenoxy)-3-oxo-propanoic acid

Conditions
ConditionsYield
at 110℃; for 3h;100%
at 100℃; for 3h; Neat (no solvent);
at 110℃; for 3h; Inert atmosphere;
at 90℃;
ortho-cresol
95-48-7

ortho-cresol

[2H]-o-cresol
92891-99-1

[2H]-o-cresol

Conditions
ConditionsYield
With perchloric acid; d(4)-methanol at 75℃; for 144h; Inert atmosphere;100%
With water-d2; sodium hydroxide at 180℃; for 0.25h; Reagent/catalyst; pH-value; Microwave irradiation; regioselective reaction;94%
4-methoxymethoxy-2-naphthalencarboxylic acid

4-methoxymethoxy-2-naphthalencarboxylic acid

ortho-cresol
95-48-7

ortho-cresol

C20H18O4

C20H18O4

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;100%
C16H11I

C16H11I

ortho-cresol
95-48-7

ortho-cresol

C23H18O

C23H18O

Conditions
ConditionsYield
Stage #1: ortho-cresol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.0833333h;
Stage #2: C16H11I In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 12h;
100%
ortho-cresol
95-48-7

ortho-cresol

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

2-methylmethoxybenzene
578-58-5

2-methylmethoxybenzene

Conditions
ConditionsYield
With Magnesium-Aluminum layered double oxides catalyst at 149.84℃; under 760.051 Torr; for 12h; Autoclave; Inert atmosphere; Irradiation; Green chemistry;99.4%
With dimanganese decacarbonyl at 180℃; for 1h; Reagent/catalyst;30%
N,N,N',N'-tetrabutyl-N''-methylguanidine at 180℃; for 4.5h;90 % Chromat.
ortho-cresol
95-48-7

ortho-cresol

2-cyanobenzyl chloride
612-13-5

2-cyanobenzyl chloride

2-(2-methylphenoxymethyl)benzonitrile
951906-92-6

2-(2-methylphenoxymethyl)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 6h;99.3%
butyl glycolate
7397-62-8

butyl glycolate

ortho-cresol
95-48-7

ortho-cresol

n-butyl o-tolyloxyacetate

n-butyl o-tolyloxyacetate

Conditions
ConditionsYield
With Mo2P5-MCM-48 at 120℃; for 3h;99.2%
ortho-cresol
95-48-7

ortho-cresol

2-Methylcyclohexanol
583-59-5

2-Methylcyclohexanol

Conditions
ConditionsYield
With hydrogen In water at 20℃; under 7500.75 Torr; for 6h; Autoclave;99.1%
With hydrogen at 100℃; under 3750.38 Torr; for 3h; Reagent/catalyst; Pressure; Temperature;99%
With nickel(II) oxide; hydrogen; palladium In hexane at 80℃; under 7500.75 Torr; for 10h;98%
formaldehyd
50-00-0

formaldehyd

Octanethiol
111-88-6

Octanethiol

ortho-cresol
95-48-7

ortho-cresol

methyl iodide
74-88-4

methyl iodide

2,4-bis(n-octylthiomethyl)-6-methylphenol
110553-27-0

2,4-bis(n-octylthiomethyl)-6-methylphenol

Conditions
ConditionsYield
Stage #1: formaldehyd; Octanethiol; ortho-cresol With hydrogenchloride; 2,2'-iminobis[ethanol] In water for 8h; pH=Ca. 3 - 4; Reflux;
Stage #2: methyl iodide With copper(l) iodide at 95℃; for 4h; Temperature;
99.1%
2-bromo-pyridine
109-04-6

2-bromo-pyridine

ortho-cresol
95-48-7

ortho-cresol

2-(o-tolyloxy)pyridine
4783-78-2

2-(o-tolyloxy)pyridine

Conditions
ConditionsYield
With potassium carbonate; 1-Butylimidazole; copper(l) chloride In tetradecane; toluene at 120℃; for 16h; Product distribution / selectivity;99%
With 2-Picolinic acid; potassium phosphate; copper(l) iodide In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere;95%
With 2-Picolinic acid; potassium phosphate; copper(l) iodide In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere;95%
ortho-cresol
95-48-7

ortho-cresol

acetyl chloride
75-36-5

acetyl chloride

2-methylphenyl acetate
533-18-6

2-methylphenyl acetate

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In acetonitrile at 20℃; for 1h;99%
With trifluorormethanesulfonic acid In acetonitrile at 20℃;96%
at 130℃; for 3h;95%

95-48-7Relevant articles and documents

Impact of oxygen vacancies in Ni supported mixed oxide catalysts on anisole hydrodeoxygenation

Ali, Hadi,Kansal, Sushil Kumar,Lauwaert, Jeroen,Saravanamurugan, Shunmugavel,Thybaut, Joris W.,Vandevyvere, Tom

, (2022/03/02)

The hydrodeoxygenation (HDO) activity of anisole has been investigated over Ni catalysts on mixed metal oxide supports containing Nb–Zr and Ti–Zr in 1:1 and 1:4 ratios. XRD patterns indicate the incorporation of Ti (or Nb) into the ZrO2 framewo

Catalytic Activation of Unstrained C(Aryl)-C(Alkyl) Bonds in 2,2′-Methylenediphenols

Dong, Guangbin,Ratchford, Benjamin L.,Xue, Yibin,Zhang, Rui,Zhu, Jun

supporting information, p. 3242 - 3249 (2022/02/23)

Catalytic activation of unstrained and nonpolar C-C bonds remains a largely unmet challenge. Here, we describe our detailed efforts in developing a rhodium-catalyzed hydrogenolysis of unstrained C(aryl)-C(alkyl) bonds in 2,2′-methylenediphenols aided by removable directing groups. Good yields of the monophenol products are obtained with tolerating a wide range of functional groups. In addition, the reaction is scalable, and the catalyst loading can be reduced to as low as 0.5 mol %. Moreover, this method proves to be effective to cleave C(aryl)-C(alkyl) linkages in both models of phenolic resins and commercial novolacs resins. Finally, detailed experimental and computational mechanistic studies show that with C-H activation being a competitive but reversible off-cycle reaction, this transformation goes through a directed C(aryl)-C(alkyl) oxidative addition pathway.

A mild desilylation of phenolic tert-butyldimethylsilyl ethers using in situ generated tetraethylammonium superoxide

Pandey, Surabhi,Shukla, Ajay K.,Raghuvanshi, Raghvendra S.

, p. 809 - 811 (2021/07/16)

Desilylation of phenolic tert-butyldimethylsilyl ethers has been achieved under the mild reaction conditions of in situ generated tetraethylammonium superoxide, at room temperature. (Figure presented.).

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