950773-03-2Relevant articles and documents
The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3- benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists
Johnson, Dale J.,Forbes, Ian T.,Watson, Steve P.,Garzya, Vincenzo,Stevenson, Graeme I.,Walker, Graham R.,Mudhar, Harminder S.,Flynn, Sean T.,Wyman, Paul A.,Smith, Paul W.,Murkitt, Graham S.,Lucas, Adam J.,Mookherjee, Claudette R.,Watson, Jeannette M.,Gartlon, Jane E.,Bradford, Andrea M.,Brown, Fiona
scheme or table, p. 5434 - 5438 (2011/02/21)
A series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles are reported which were found to be potent and selective muscarinic M1 agonists. By control of the physicochemical characteristics of the series, particularly the li
BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE
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, (2008/06/13)
Compounds of formula (I), salts and solvates are provided: formula (I), wherein Q, R and R6 are as defined in the claims. Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.
