952-08-9

Basic information

• Product Name: 1H-Imidazole, 2,2'-(1,3-phenylene)bis[4,5-dihydro-
• CAS NO: 952-08-9
• Molecular Formula: C12H14N4
• Molecular Weight: 214.27
• Mol File: 952-08-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole, 2,2'-(1,3-phenylene)bis[4,5-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole, 2,2'-(1,3-phenylene)bis[4,5-dihydro-(952-08-9)
• EPA Substance Registry System: 1H-Imidazole, 2,2'-(1,3-phenylene)bis[4,5-dihydro-(952-08-9)

Safety Data

• Hazardous Substances Data: 952-08-9(Hazardous Substances Data)

Usage

Chemical class

Imidazole

Central ring structure

Imidazole

Substituent

1,3-Phenylene

Additional substituents

Two 4,5-Dihydrosubstituents on the phenylene ring

Usage

Different sources of media describe the Usage of 952-08-9 differently. You can refer to the following data:
1. Building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds
2. Ligand in coordination chemistry and study of metal-ligand interactions

Potential

Biological activities, research tool in the study of imidazole-containing compounds.

Upstream product

• 120-93-4 imidazolidone 
• 121-91-5 isophthalic acid 
• 626-19-7 Isophthalaldehyde 
• 107-15-3 ethylenediamine 
• 17527-68-3 Dimethyl benzene-1,3-bis 
• 626-17-5 benzene-1,3-dicarbonitrile 

Downstream Products

• 21202-39-1 1,3-bis(1H-imidazol-2-yl)benzene 

Relevant articles and documents

Activation of Electron-Deficient Quinones through Hydrogen-Bond-Donor-Coupled Electron Transfer

Quinones are important organic oxidants in a variety of synthetic and biological contexts, and they are susceptible to activation towards electron transfer through hydrogen bonding. Whereas this effect of hydrogen bond donors (HBDs) has been observed for Lewis basic, weakly oxidizing quinones, comparable activation is not readily achieved when more reactive and synthetically useful electron-deficient quinones are used. We have successfully employed HBD-coupled electron transfer as a strategy to activate electron-deficient quinones. A systematic investigation of HBDs has led to the discovery that certain dicationic HBDs have an exceptionally large effect on the rate and thermodynamics of electron transfer. We further demonstrate that these HBDs can be used as catalysts in a quinone-mediated model synthetic transformation.

Efficient and one-pot catalytic synthesis of 2-imidazolines and bis-imidazolines with p-toluenesulfonic acid under solvent free conditions

A practical, efficient, and inexpensive method for the synthesis of 2-imidazoline from the reaction of nitriles with ethylenediamine or 1,2-propanediamine using p-toluenesulfonic acid or pyridinium p-toluenesulfonate under reflux conditions is reported. This catalyst can be successfully applied for the chemoselective conversion of dicyanobenzenes to corresponding mono- and bis-imidazolines. The applications of these catalysts are feasible because of easy preparation, easy handling, stability, inexpensive, good activity, and eco-friendly.

Rapid and efficient synthesis of imidazolines and bisimidazolines under microwave and ultrasonic irradiation

Small assemblies of 2-imidazolines and bisimidazolines from appropriate nitriles and ethylenediamine with catalytic amounts of P2S 5 employing a microwave assisted protocol were prepared. Sonication of this system also led to successful synthesis of 2-imidazolines and bisimidazolines. Another advantage of these systems is the ability to carry out large scale reactions. Springer-Verlag 2007.