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961-68-2

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961-68-2 Usage

Chemical Properties

solid

Preparation

Aniline and 1-Chloro-2,4-dinitrobenzene?condensation

Properties and Applications

Bright green light yellow. Insoluble in water, slightly soluble in alcohol. The strong sulfuric acid for brown, after dilute for light yellow. Add sodium hydroxide solution for yellow dye. Used in vinegar, spandex fiber dyeing, also can be used for plastic color. StandardVinegar fiber Ironing Fastness Light Fastness Persperation Fastness Washing Fastness Fading Stain Fading Stain Fading Stain ISO 3-4 5 3 3-4 4

Fading

Stain

Purification Methods

The amine forms red pKEst crystals from aqueous EtOH or CHCl3/EtOH (m 158o). The UV has max at 335nm (cyclohexane). [Beilstein 12 H 751, 12 III 1683, 12 IV 1692.]

Check Digit Verification of cas no

The CAS Registry Mumber 961-68-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,6 and 1 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 961-68:
(5*9)+(4*6)+(3*1)+(2*6)+(1*8)=92
92 % 10 = 2
So 961-68-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H9N3O4/c16-14(17)10-6-7-11(12(8-10)15(18)19)13-9-4-2-1-3-5-9/h1-8,13H

961-68-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4-Dinitrodiphenylamine

1.2 Other means of identification

Product number -
Other names Benzenamine, 2,4-dinitro-N-phenyl-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:961-68-2 SDS

961-68-2Synthetic route

2,4-dinitrobromobenzene
584-48-5

2,4-dinitrobromobenzene

aniline
62-53-3

aniline

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
With tetrabutylammomium bromide; palladium diacetate; caesium carbonate; ruphos In dimethyl sulfoxide at 100℃; for 17h; Inert atmosphere;98%
2,4-Dinitrofluorobenzene
70-34-8

2,4-Dinitrofluorobenzene

aniline
62-53-3

aniline

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran for 25h; Inert atmosphere;97%
In dimethyl sulfoxide at 100℃; for 16h; Inert atmosphere;85%
In methanol at 0 - 20℃; for 18h;85.3%
2,4-dinitrophenyl N-phenylbenzimidate
107569-59-5

2,4-dinitrophenyl N-phenylbenzimidate

A

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

B

benzoic acid
65-85-0

benzoic acid

Conditions
ConditionsYield
With sodium hydroxide In water for 4h; Ambient temperature;A 96%
B n/a
aniline
62-53-3

aniline

1-chloro-2,4-dinitro-benzene
97-00-7

1-chloro-2,4-dinitro-benzene

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
In neat (no solvent) at 30℃; for 0.166667h; Reagent/catalyst; Green chemistry;95%
In dimethyl sulfoxide at 20℃; for 24h;93%
With sodium acetate In ethanol at 78℃; for 1h;91%
2,4-Dinitrofluorobenzene
70-34-8

2,4-Dinitrofluorobenzene

Cyclohexyl N-phenylsulfamate
85599-59-3

Cyclohexyl N-phenylsulfamate

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
With sodium carbonate; N-benzyl-N,N,N-triethylammonium chloride In benzene Ambient temperature;89%
phenylboronic acid
98-80-6

phenylboronic acid

2,4-Dinitroanilin
97-02-9

2,4-Dinitroanilin

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
With potassium acetate In N,N-dimethyl-formamide at 20℃; for 15h;79%
meta-dinitrobenzene
99-65-0

meta-dinitrobenzene

aniline
62-53-3

aniline

A

2,4-Dinitrophenol
51-28-5

2,4-Dinitrophenol

B

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
With potassium permanganate; tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 20℃; for 1h;A 22%
B 75%
iodobenzene
591-50-4

iodobenzene

2,4-Dinitroanilin
97-02-9

2,4-Dinitroanilin

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
With CuMoO4; caesium carbonate In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere;72%
bromobenzene
108-86-1

bromobenzene

2,4-Dinitroanilin
97-02-9

2,4-Dinitroanilin

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
With CuMoO4; caesium carbonate In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere;64%
meta-dinitrobenzene
99-65-0

meta-dinitrobenzene

aniline
62-53-3

aniline

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 20℃; for 3h; Substitution; UV-irradiation;54%
Stage #1: aniline With n-butyllithium In tetrahydrofuran; hexane at -78 - -70℃; Inert atmosphere;
Stage #2: meta-dinitrobenzene In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere;
glycolanilide
4746-61-6

glycolanilide

1-(2,4-dinitrophenyl)-4-methyl-3,5-dinitropyrazole
58333-00-9

1-(2,4-dinitrophenyl)-4-methyl-3,5-dinitropyrazole

A

2,4-Dinitrophenol
51-28-5

2,4-Dinitrophenol

B

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

C

2-(2,4-dinitrophenoxy)-N-phenylacetamide
20916-37-4

2-(2,4-dinitrophenoxy)-N-phenylacetamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 4h; Reflux;A Ca. 0.015 g
B 25%
C 52%
2,4-Dinitrodiphenylacetamide
106038-76-0

2,4-Dinitrodiphenylacetamide

A

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

B

2-nitrophenazine 10-oxide
2876-33-7

2-nitrophenazine 10-oxide

Conditions
ConditionsYield
With trifluoroacetic acid In benzene for 0.583333h; Irradiation;A 80 % Turnov.
B 15%
With trifluoroacetic acid In benzene Irradiation;
With trifluoroacetic acid In benzene for 0.583333h; Irradiation; also with 1,4-diazabicyclo<2.2.2>octane (DABCO); also flash photolysis;A 80 % Turnov.
B 15 % Turnov.
1,4-dioxane
123-91-1

1,4-dioxane

aniline
62-53-3

aniline

1-chloro-2,4-dinitro-benzene
97-00-7

1-chloro-2,4-dinitro-benzene

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
at 45℃; Rate constant;
tetrachloromethane
56-23-5

tetrachloromethane

ethanol
64-17-5

ethanol

N-(2,4-dinitro-phenyl)-N,N'-diphenyl-urea

N-(2,4-dinitro-phenyl)-N,N'-diphenyl-urea

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
beim Verduennen Abscheidung des Produktes;
beim Ansaeuern Abscheidung des Produktes;
benzylidene phenylamine
538-51-2

benzylidene phenylamine

1-chloro-2,4-dinitro-benzene
97-00-7

1-chloro-2,4-dinitro-benzene

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
With ethanol
ethanol
64-17-5

ethanol

ethyl acetate
141-78-6

ethyl acetate

aniline
62-53-3

aniline

1-chloro-2,4-dinitro-benzene
97-00-7

1-chloro-2,4-dinitro-benzene

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
at 24℃; Rate constant;
ethyl acetate
141-78-6

ethyl acetate

aniline
62-53-3

aniline

1-chloro-2,4-dinitro-benzene
97-00-7

1-chloro-2,4-dinitro-benzene

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
at 24℃; Rate constant;
2,4-dinitrobromobenzene
584-48-5

2,4-dinitrobromobenzene

ethanol
64-17-5

ethanol

N-Phenylhydroxylamine
100-65-2

N-Phenylhydroxylamine

A

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

B

N-(2,4-dinitro-phenyl)-N-phenyl-hydroxylamine

N-(2,4-dinitro-phenyl)-N-phenyl-hydroxylamine

C

aniline hydrobromide
542-11-0

aniline hydrobromide

2,4-dinitrobromobenzene
584-48-5

2,4-dinitrobromobenzene

ethanol
64-17-5

ethanol

N-Phenylhydroxylamine
100-65-2

N-Phenylhydroxylamine

A

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

B

N-(2,4-dinitro-phenyl)-N-phenyl-hydroxylamine

N-(2,4-dinitro-phenyl)-N-phenyl-hydroxylamine

C

aniline
62-53-3

aniline

2,4-dinitrobromobenzene
584-48-5

2,4-dinitrobromobenzene

N-Phenylhydroxylamine
100-65-2

N-Phenylhydroxylamine

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
With ethanol
ethanol
64-17-5

ethanol

2,4-dinitro-phenyl thiocyanate
1594-56-5

2,4-dinitro-phenyl thiocyanate

aniline
62-53-3

aniline

A

bis(2,4-dinitrophenyl) disulphide
2217-55-2

bis(2,4-dinitrophenyl) disulphide

B

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

C

bis-(2,4-dinitro-phenyl)-sulfide
2253-67-0

bis-(2,4-dinitro-phenyl)-sulfide

D

monophenylthiourea
103-85-5

monophenylthiourea

ethanol
64-17-5

ethanol

1-(2,4-dinitrophenyl)-3-methylpyridinium chloride
6526-37-0

1-(2,4-dinitrophenyl)-3-methylpyridinium chloride

aniline
62-53-3

aniline

A

3-Methylpyridine
108-99-6

3-Methylpyridine

B

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

C

2,4-Dinitroanilin
97-02-9

2,4-Dinitroanilin

chloroform
67-66-3

chloroform

(2,4-dichloro-5-nitro-phenyl)-(2,4-dinitro-phenyl)-ether
859775-56-7

(2,4-dichloro-5-nitro-phenyl)-(2,4-dinitro-phenyl)-ether

aniline
62-53-3

aniline

A

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

B

2,4-dichloro-5-nitrophenol
39489-77-5

2,4-dichloro-5-nitrophenol

2,4-dinitrophenyl phenyl ether
2486-07-9

2,4-dinitrophenyl phenyl ether

aniline
62-53-3

aniline

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Conditions
ConditionsYield
at 180℃;
1-(2-naphthoxy)-2,4-dinitrobenzene
2734-77-2

1-(2-naphthoxy)-2,4-dinitrobenzene

aniline
62-53-3

aniline

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

2,4-dinitrophenyl 4-methylbenzenesulfonate
742-25-6

2,4-dinitrophenyl 4-methylbenzenesulfonate

aniline
62-53-3

aniline

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

bis(2,4-dinitrophenyl) ether
2217-56-3

bis(2,4-dinitrophenyl) ether

aniline
62-53-3

aniline

A

2,4-Dinitrophenol
51-28-5

2,4-Dinitrophenol

B

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

bis(2,4-dinitrophenyl) ether
2217-56-3

bis(2,4-dinitrophenyl) ether

aniline
62-53-3

aniline

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

1-iodo-2,6-dinitrobenzene
26516-42-7

1-iodo-2,6-dinitrobenzene

aniline
62-53-3

aniline

A

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

B

2,6-dinitro-N-phenyl-benzenamine
13744-81-5

2,6-dinitro-N-phenyl-benzenamine

1,3-bis-(2,4-dinitro-phenoxy)-benzene
3761-11-3

1,3-bis-(2,4-dinitro-phenoxy)-benzene

aniline
62-53-3

aniline

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

2-amino-4-nitro-N1-phenylaniline
55315-12-3

2-amino-4-nitro-N1-phenylaniline

Conditions
ConditionsYield
With sodium sulfide; water; sulfur In ethanol for 2h; Reflux;99%
With sodium sulfide; sodium hydrogencarbonate In ethanol; water at 80℃;81.8%
With ammonium hydroxide; ethanol; hydrogen sulfide
N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

2,4-diaminodiphenylamine
136-17-4

2,4-diaminodiphenylamine

Conditions
ConditionsYield
With hydrazine; nickel In tetrahydrofuran; ethanol at 20℃; for 0.333333h;87%
With hydrogenchloride; iron
With hydrogenchloride; tin
N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

A

1-anilino-4-amino-2-nitrobenzene
2784-89-6

1-anilino-4-amino-2-nitrobenzene

B

2-amino-4-nitro-N1-phenylaniline
55315-12-3

2-amino-4-nitro-N1-phenylaniline

Conditions
ConditionsYield
With nickel; hydrazine hydrate In ethanol; 1,2-dichloro-ethane at 50 - 60℃; for 4h;A 29%
B 70%
formic acid
64-18-6

formic acid

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

A

1-phenylbenzimidazol-5-amine
53897-95-3

1-phenylbenzimidazol-5-amine

B

5-nitro-1-phenyl-1H-benzo[d]imidazole
15127-88-5

5-nitro-1-phenyl-1H-benzo[d]imidazole

Conditions
ConditionsYield
Stage #1: N-phenyl-2,4-dinitroaniline With hydrogen; palladium 10% on activated carbon In ethyl acetate for 52h;
Stage #2: formic acid With hydrogenchloride In water at 78 - 80℃; for 22h; Inert atmosphere;
Stage #3: With sodium hydroxide In water at 20℃; pH=12;
A 25%
B 61%
N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

phenylglycin
2835-06-5

phenylglycin

5-nitro-1,2-diphenyl-1H-benzimidazole
853791-71-6

5-nitro-1,2-diphenyl-1H-benzimidazole

Conditions
ConditionsYield
With iron(III) chloride; potassium carbonate In toluene at 120℃; for 16h;58%
N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

(+/-)-2-amino-2'-fluorophenylacetic acid
84145-28-8

(+/-)-2-amino-2'-fluorophenylacetic acid

5-nitro-2-(2-fluorophenyl)-1-phenyl-1H-benzimidazole

5-nitro-2-(2-fluorophenyl)-1-phenyl-1H-benzimidazole

Conditions
ConditionsYield
With iron(III) chloride; potassium carbonate In toluene at 120℃; for 16h;56%
N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

1-anilino-4-amino-2-nitrobenzene
2784-89-6

1-anilino-4-amino-2-nitrobenzene

Conditions
ConditionsYield
With sulfuric acid; hydrogen; platinum on activated charcoal In acetic acid at 85℃;45%
methanol
67-56-1

methanol

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

(2,4-dinitro-phenyl)-phenyl-aniline; compound with potassium ethanolate

(2,4-dinitro-phenyl)-phenyl-aniline; compound with potassium ethanolate

Conditions
ConditionsYield
With potassium hydroxide
diethyl sulfate
64-67-5

diethyl sulfate

N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

ethyl-(2,4-dinitro-phenyl)-phenyl-amine
58133-79-2

ethyl-(2,4-dinitro-phenyl)-phenyl-amine

Conditions
ConditionsYield
With potassium hydroxide
N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

2-nitrophenazine
3442-62-4

2-nitrophenazine

Conditions
ConditionsYield
at 360℃;
N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

A

(2,4-dinitro-phenyl)-(2-nitro-phenyl)-amine
14434-10-7

(2,4-dinitro-phenyl)-(2-nitro-phenyl)-amine

B

2,4-dinitro-N-(4-nitrophenyl)aniline
970-76-3

2,4-dinitro-N-(4-nitrophenyl)aniline

Conditions
ConditionsYield
Nitrieren;
With nitric acid; acetic acid
N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

bis(2,4-dinitrophenyl)amine
2908-76-1

bis(2,4-dinitrophenyl)amine

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 80 - 90℃;
With nitric acid; acetic acid; N-nitrosodiphenylamine
With nitric acid at 40 - 90℃; mit 53prozentiger Salpetersaeure;
N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

Dipikrylamin
131-73-7

Dipikrylamin

Conditions
ConditionsYield
technische Gewinnung;
With nitric acid
Nitrierung;
N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

acetic anhydride
108-24-7

acetic anhydride

2,4-Dinitrodiphenylacetamide
106038-76-0

2,4-Dinitrodiphenylacetamide

Conditions
ConditionsYield
With perchloric acid
With zinc(II) chloride
N-phenyl-2,4-dinitroaniline
961-68-2

N-phenyl-2,4-dinitroaniline

acetic acid
64-19-7

acetic acid

isopentyl nitrite
110-46-3

isopentyl nitrite

bis(2,4-dinitrophenyl)amine
2908-76-1

bis(2,4-dinitrophenyl)amine

Conditions
ConditionsYield
at 18℃;

961-68-2Relevant articles and documents

-

Bunnett,Davis

, p. 4337 (1958)

-

-

Ross,Kuntz

, p. 3000 (1954)

-

Bain,Ouellet

, p. 646,650, 653 (1951)

-

Ogata,Okano

, (1952)

-

Incorporation of: N -phenyl in poly(benzimidazole imide)s and improvement in H2O-absorbtion and transparency

Qian, Guangtao,Dai, Fengna,Chen, Haiquan,Wang, Mengxia,Hu, Mengjie,Chen, Chunhai,Yu, Youhai

, p. 3770 - 3776 (2021/02/03)

5-Amine-2-(4-amino-benzene)-1-phenyl-benzimidazole (N-PhPABZ) was successfully synthesized and polymerized with 3,3′,4,4′-biphenyl tetracarboxylic dianhydride (BPDA) to obtain a novel N-phenyl-poly(benzimidazole imide) (N-Ph-PBII). The successful incorporation of N-phenyl addressed the issue of high H2O-absorption of traditional PBIIs while retained the superheat resistance property. The resulting N-Ph-PBII possessed a high glass-transition temperature (Tg) up to 425 °C and a low affinity for water of 1.4%. Furthermore, the loose molecular packing and noncoplanar structures led to an increase in optical transparency for the modified PBII.

Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer

Tokay, Esra,Güng?r, Tu?ba,Hac?o?lu, Nelin,?nder, Ferah C?mert,Gülhan, ünzile Güven,Tok, Tu?ba Ta?k?n,?elik, Ayhan,Ay, Mehmet,K??kar, Feray

, (2019/12/24)

Prodrugs for targeted tumor therapies have been extensively studied in recent years due to not only maximising therapeutic effects on tumor cells but also reducing or eliminating serious side effects on healthy cells. This strategy uses prodrugs which are safe for normal cells and form toxic metabolites (drugs) after selective reduction by enzymes in tumor tissues. In this study, prodrug candidates (1-36) containing nitro were designed, synthesized and characterized within the scope of chemical experiments. Drug-likeness properties of prodrug candidates were analyzed using DS 2018 to investigate undesired toxicity effects. In vitro cytotoxic effects of prodrug canditates were performed with MTT assay for human hepatoma cells (Hep3B) and prostate cancer cells (PC3) and human umbilical vein endothelial cells (HUVEC) as healthy control. Non-toxic compounds (3, 5, 7, 10, 12, 15, 17, 19 and 21–23), and also compounds (1, 2, 5, 6, 9, 11, 14, 16, 20 and 24) which had low toxic effects, were selected to examine their suitability as prodrug canditates. The reduction profiles and kinetic studies of prodrug/Ssap-NtrB combinations were performed with biochemical analyses. Then, selected prodrug/Ssap-NtrB combinations were applied to prostate cancer cells to determine toxicity. The results of theoretical, in vitro cytotoxic and biochemical studies suggest 14/Ssap-NtrB, 22/Ssap-NtrB and 24/Ssap-NtrB may be potential prodrug/enzyme combinations for nitroreductase (Ntr)-based prostate cancer therapy.

Recyclable bimetallic CuMoO4 nanoparticles for C-N cross-coupling reaction under mild conditions

Panigrahi, Reba,Panda, Subhalaxmi,Behera, Pradyota Kumar,Sahu, Santosh Kumar,Rout, Laxmidhar

supporting information, p. 19274 - 19278 (2019/12/24)

Herein we disclosed inexpensive copper(ii) bimetallic CuMoO4 nanoparticles for the C-N cross-coupling reaction of alkyl and aryl amines with haloarenes. The reaction proceeds under mild and ligand free conditions. The catalyst is recyclable and effective for a wide range of amines and haloarenes. Here, the efficiency of the Cu(ii) catalyst is increased by doping molybdenum metal. The bimetallic nanoparticles are anticipated to proceed via normal oxidative addition and reductive eliminations.

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