97-52-9Relevant articles and documents
Preparation method of 2-methoxy-4-nitroaniline
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Paragraph 0051; 0054; 0064; 0065; 0067-0073; 0078, (2019/06/12)
The invention discloses a preparation method of 2-methoxy-4-nitroaniline. The preparation method comprises the following steps of: carrying out acetylation reaction of o-methoxyaniline and acetic acid, discharging water generated in the acetylation reaction process from a reaction system, dropwisely adding fuming nitric acid into the prepared acetic acid solution of the o-methoxyacetanilide to carry out nitration reaction, adding deionized water after the nitration reaction is finished and then filtering, adding the prepared 2-methoxy-4-nitroaniline into an alkali solution to carry out hydrolysis reaction; after the hydrolysis reaction is finished, cooling the prepared reaction solution, and filtering to obtain 2-methoxy-4-nitroaniline. By adopting the method to synthesize 2-methoxy-4-nitroaniline, the acylation reaction cost is low, the nitration reaction selectivity is high, the discharge of three wastes is reduced, the production cost is reduced, the product purity is high, the yield is high, and the 2-methoxy-4-nitroaniline has a good industrial application value.
Process for preparing red-B preparation method
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Paragraph 0039, (2017/12/02)
The invention relates to a preparation method for a red base B. A formylation reaction is performed on o-aminoanisole and formic acid at 80-102 DEG C on the condition that acylation reaction solvent exists, and filtration is performed to obtain o-formamide anisole after the formylation reaction is completed; the o-formamide anisole is added into a sulfuric acid solution, nitric acid is added into a reaction system to perform a nitration reaction when the temperature of the reaction system is controlled at 0-70 DEG C, and filtration is performed to obtain methoxyl-4-nitroformanilide after the nitration reaction is completed; a hydrolysis reaction is performed on the methoxyl-4-nitroformanilide on the condition that the sulfuric acid and water exist at 80-120 DEG C, after the hydrolysis reaction is completed, separation is performed, the pH value is regulated to 6-7 with sodium carbonate, and then filtration is performed to obtain the red base B. According to the preparation method, the produce yield is high, the cost is low, the quality is good, by-products are less, waste water generated in the production process of the red base B is greatly reduced, the clean production requirement is met, operation is easy and convenient, and industrialization is facilitated.
Steric-Hindrance-Induced Regio- and Chemoselective Oxidation of Aromatic Amines
Patil, Vilas Venunath,Shankarling, Ganapati Subray
, p. 7876 - 7883 (2015/09/01)
Unusual regio- and chemoselective oxidation of aromatic amines hindered with ortho substituents (except -NH2, -NHCH3, and -OH) to the corresponding nitro compounds is described by use of nonanebis(peroxoic acid). The mechanistic investigation for selective oxidation of amines ortho-substituted with -NH2 or -OH showed the involvement of H-bonding between the ortho hydrogen of the adjacent -XH group (where X = NH, NR, or O) and an oxygen atom from the diperoxy acid. Various mono- and diamines are oxidized into corresponding mononitro derivatives in high yield and purity without employing any protection strategies. The protocol was also found to successful on the gram scale.
