Welcome to LookChem.com Sign In|Join Free

CAS

  • or

97-62-1

Post Buying Request

97-62-1 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

97-62-1 Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 97-62-1 differently. You can refer to the following data:
1. Colorless volatile liquid. With aromas of fruit and cream. Melting point is -88 DEG C, and boiling point is 112 ~ 113 C. Slightly soluble in water and miscible with most organic solvents. The natural product is found in strawberries, honey, molasses, beer and champagne.
2. CLEAR COLOURLESS LIQUID
3. Ethyl isobutyrate has a fruity aromatic odor.

Uses

Different sources of media describe the Uses of 97-62-1 differently. You can refer to the following data:
1. Used as food essence and flavoring, mainly used in the preparation of cream and strawberry, cherry and other fruit essences. It can also be used as raw flavoring in cigarettes, daily chemical products and other products. At the same time, it is also an excellent organic solvent.
2. It is employed to make flavoring compounds and essences, as a flavoring agent and to flavor animal feeds.
3. Ethyl Isobutyrate is a synthetic flavoring agent that is a stable, col- orless liquid of dry, fruity odor. it should be stored in tin, glass, or resin-lined containers. it is used to give fruity effects to flavors for applications in candy, baked goods, and beverages at 10–100 ppm.
4. manufacture of flavoring Compounds and essences.

Use restriction

FEMA(mg/kg):Soft drink 10; cold drink 25;sweets 73; baked food 200; puddings6.0; piping layers 1.5.

Preparation

Different sources of media describe the Preparation of 97-62-1 differently. You can refer to the following data:
1. Obtained by esterification of isobutyric acid and anhydrous ethanol. After mixing isobutyric acid and anhydrous ethanol, carefully add concentrated sulfuric acid. After refluxing the mixture for 14h, it should be washed by water and saturated sodium bicarbonate solution and dried by anhydrous magnesium sulfate and then go through distillation. Collecting fractions at 109-111℃ and obtain 2- methyl ethyl propionate. The yield is 69 percent.
2. By esterification of ethanol with isobutyric acid under azeotropic conditions.

Toxicity

GRAS (FEMA) LD50800mg/kg (mice, subcutaneous )

Content Analysis

Adopt method one offered by the ester measurement. The sample is taken 1.0 gram by weight. Equivalent factor under calculation is taken at 58.08. It should be measured with non-polar column method used in GT-10-4.

Occurrence

Reported found in apple juice, banana, chocolate, cognac, Concord grape, honey, apricot, orange, pineapple, rum, strawberry, strawberry oil, watermelon, whiskey, champagne wine, grape wine, beer, port, passion fruit wine, sherry wine, orange juice, papaya, mango, kiwi fruit, quince, spineless monkey orange (Strychnos madagasc.), spearmint oil and Parmesan cheese.

Definition

ChEBI: A fatty acid methyl ester obtained by the formal condensation of isobutyric acid with ethanol.

Aroma threshold values

Detection: 0.01 to 1 ppb

Taste threshold values

Taste characteristics at 12.5 ppm: pungent, ethereal and fruity with a rum- and eggnog-like nuance. Taste characteristics at 20 ppm: sweet, ethereal, fruity with a rum-like nuance

Synthesis Reference(s)

Tetrahedron, 27, p. 2671, 1971 DOI: 10.1016/S0040-4020(01)98056-1Tetrahedron Letters, 28, p. 953, 1987 DOI: 10.1016/S0040-4039(00)95884-2

General Description

A colorless volatile liquid with a fruity, aromatic odor. Less dense than water and insoluble in water. Flash point below 60°F. Vapors heavier than air. May irritate skin and eyes. Used to make flavoring extracts and other chemicals.

Air & Water Reactions

Highly flammable. Insoluble in water.

Safety Profile

Moderately toxic by intraperitoneal route. A skin irritant. Flammable liquid. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Purification Methods

Wash the ester with aqueous 5% Na2CO3, then with saturated aqueous CaCl2. Dry it over CaSO4 and distil. [Beilstein 1 IV 846.]

Check Digit Verification of cas no

The CAS Registry Mumber 97-62-1 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 7 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 97-62:
(4*9)+(3*7)+(2*6)+(1*2)=71
71 % 10 = 1
So 97-62-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H12O2/c1-4-8-6(7)5(2)3/h5H,4H2,1-3H3

97-62-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A12966)  Ethyl isobutyrate, 98%   

  • 97-62-1

  • 100ml

  • 211.0CNY

  • Detail
  • Alfa Aesar

  • (A12966)  Ethyl isobutyrate, 98%   

  • 97-62-1

  • 500ml

  • 685.0CNY

  • Detail
  • Alfa Aesar

  • (A12966)  Ethyl isobutyrate, 98%   

  • 97-62-1

  • 2500ml

  • 2914.0CNY

  • Detail

97-62-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl isobutyrate

1.2 Other means of identification

Product number -
Other names Ethyl Isobutyrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:97-62-1 SDS

97-62-1Synthetic route

diethyl (trichloromethyl)phosphonate
866-23-9

diethyl (trichloromethyl)phosphonate

isobutyric Acid
79-31-2

isobutyric Acid

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
at 120℃; for 24h;98%
ethyl 2-bromoisobutyrate
600-00-0

ethyl 2-bromoisobutyrate

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
With water; lithium diisopropyl amide In tetrahydrofuran 1) -78 deg C, 30 min 2) 30 min;96%
With Graphite; acetophenone; potassium bromide In water at 25℃; Reagent/catalyst; Electrolysis;
With trans-Mo2(μ-N,N′-bis(4-methoxyphenyl)formamidinato-κ2N:N′)2(OOCCH3)2; 1-methyl-3,6-bis(trimethylsilyl)-1,4-cyclohexadiene; tetrabutyl-ammonium chloride In acetonitrile at 80℃; for 24h;73 %Spectr.
With di-tert-butoxydiazene; tri-n-butyl-tin hydride In cyclohexane at 42℃; Kinetics; Inert atmosphere; Darkness;
ethanol
64-17-5

ethanol

isobutyric Acid
79-31-2

isobutyric Acid

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
With S,S-bis<4,6-dimethyl-2-pyrimidinyl> dithiocarbonate; dmap In dichloromethane for 1.5h; Ambient temperature;91%
With toluene-4-sulfonic acid In cyclohexane Reflux;68.9%
With Rhizomucor miehei lipase In n-heptane at 40℃; for 24h; Enzymatic reaction;65.7%
ethanol
64-17-5

ethanol

1-(3,3-Dimethyl-2-thioxo-2,3-dihydro-indol-1-yl)-2-methyl-propan-1-one

1-(3,3-Dimethyl-2-thioxo-2,3-dihydro-indol-1-yl)-2-methyl-propan-1-one

A

3,3-dimethyl-2,3-dihydroindol-2-thione
19155-25-0

3,3-dimethyl-2,3-dihydroindol-2-thione

B

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
In benzene Product distribution; Irradiation;A 90%
B 90%
ethanol
64-17-5

ethanol

di-isopropyl azodicarboxylate
2446-83-5

di-isopropyl azodicarboxylate

2,4-dimethylpentan-3-one
565-80-0

2,4-dimethylpentan-3-one

A

diisopropyl 1-isopropylhydrazine-1,2-dicarboxylate

diisopropyl 1-isopropylhydrazine-1,2-dicarboxylate

B

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
Stage #1: di-isopropyl azodicarboxylate; 2,4-dimethylpentan-3-one With cerium(IV) trifluoromethanesulfonate; trimethylsilyl cyanide; 9,10-diphenylanthracene; tetrabutyl-ammonium chloride; titanium tetrachloride In acetonitrile at 0 - 50℃; for 24h; Inert atmosphere; Irradiation; Glovebox;
Stage #2: ethanol With triethylamine In acetonitrile at 20℃; for 2h; Inert atmosphere; Glovebox;
A 87%
B 90 %Chromat.
2-isopropyl-1,3-dioxolane
822-83-3

2-isopropyl-1,3-dioxolane

A

2-hydroxyethyl isobutyrate
6942-58-1

2-hydroxyethyl isobutyrate

B

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
With Cumene hydroperoxide In chlorobenzene at 130℃; for 1h; Product distribution; Rate constant;A 70%
B n/a
With Cumene hydroperoxide at 110℃;
ethyl 2-methyl-2-methyl tellurium propionate
474094-06-9

ethyl 2-methyl-2-methyl tellurium propionate

A

dimethyl ditelluride
20334-43-4

dimethyl ditelluride

B

isobutyric Acid
79-31-2

isobutyric Acid

C

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
With potassium hydroxide In tetrahydrofuran; water at 70℃; for 3h; Inert atmosphere;A 52%
B 14%
C 22%
ethyl 2-bromoisobutyrate
600-00-0

ethyl 2-bromoisobutyrate

dimanganese decacarbonyl
10170-69-1

dimanganese decacarbonyl

A

diethyl 2,2,3,3-tetramethylsuccinate
33367-54-3

diethyl 2,2,3,3-tetramethylsuccinate

B

diethyl 2,2,3,5,5-pentamethylhexa-1,6-dioate

diethyl 2,2,3,5,5-pentamethylhexa-1,6-dioate

C

diethyl 2,2-dimethyl-4-methylenepenta-1,5-dioate
106471-98-1

diethyl 2,2-dimethyl-4-methylenepenta-1,5-dioate

D

methyl methacrylate
97-63-2

methyl methacrylate

E

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
In tetrahydrofuran Irradiation (UV/VIS); (N2 or Ar); 250-W sun lamp, 3 h; colorless solution is filtered, (1)H-NMR;A 45%
B 13%
C 5%
D 12%
E 17%
In chloroform-d1 Irradiation (UV/VIS); (N2 or Ar); 250-W sun lamp, 3 h; colorless solution is filtered, (1)H-NMR;A 36%
B 9%
C 4%
D 5%
E 13%
ethanol
64-17-5

ethanol

1-Isobutyryl-3,3-dimethyl-1,3-dihydro-indol-2-one

1-Isobutyryl-3,3-dimethyl-1,3-dihydro-indol-2-one

A

3,3-dimethyloxindole
19155-24-9

3,3-dimethyloxindole

B

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
In benzene Product distribution; Irradiation;A 41%
B 38%
ethyl 2-bromoisobutyrate
600-00-0

ethyl 2-bromoisobutyrate

A

diethyl 2,2,3,3-tetramethylsuccinate
33367-54-3

diethyl 2,2,3,3-tetramethylsuccinate

B

diethyl 2,2-dimethyl-4-methylenepenta-1,5-dioate
106471-98-1

diethyl 2,2-dimethyl-4-methylenepenta-1,5-dioate

C

methyl methacrylate
97-63-2

methyl methacrylate

D

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
With {bis(triphenylphosphine)nitrogen}{manganese(carbonyl)5} In tetrahydrofuran for 5h;A 36%
B 3%
C 6%
D 35%
ethyl 2-bromoisobutyrate
600-00-0

ethyl 2-bromoisobutyrate

bis(triphenylphosphineiminium) pentacarbonylmanganate(1-)
52542-59-3, 192520-17-5

bis(triphenylphosphineiminium) pentacarbonylmanganate(1-)

A

diethyl 2,2,3,3-tetramethylsuccinate
33367-54-3

diethyl 2,2,3,3-tetramethylsuccinate

B

diethyl 2,2-dimethyl-4-methylenepenta-1,5-dioate
106471-98-1

diethyl 2,2-dimethyl-4-methylenepenta-1,5-dioate

C

methyl methacrylate
97-63-2

methyl methacrylate

D

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
In tetrahydrofuran (N2 or Ar); solution is allowed to stand for 5 h; determination by NMR and MS fragmentation;A 36%
B 3%
C 6%
D 35%
ethyl 2-bromoisobutyrate
600-00-0

ethyl 2-bromoisobutyrate

sodium pentacarbonyl manganate
13859-41-1

sodium pentacarbonyl manganate

A

diethyl 2,2,3,3-tetramethylsuccinate
33367-54-3

diethyl 2,2,3,3-tetramethylsuccinate

B

diethyl 2,2-dimethyl-4-methylenepenta-1,5-dioate
106471-98-1

diethyl 2,2-dimethyl-4-methylenepenta-1,5-dioate

C

methyl methacrylate
97-63-2

methyl methacrylate

D

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
In tetrahydrofuran (N2 or Ar); solution is allowed to stand for 5 h; determination by NMR and MS fragmentation;A 14%
B 1%
C 16%
D 36%
ethanol
64-17-5

ethanol

3-isobutanoyl-thiazolidine-2-thione
151699-17-1

3-isobutanoyl-thiazolidine-2-thione

A

thiazolidine-2-thione
134469-06-0

thiazolidine-2-thione

B

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
Irradiation; Yields of byproduct given;A n/a
B 17%
ethyl 2-bromoisobutyrate
600-00-0

ethyl 2-bromoisobutyrate

A

diethyl 2,2,3,3-tetramethylsuccinate
33367-54-3

diethyl 2,2,3,3-tetramethylsuccinate

B

diethyl 2,2-dimethyl-4-methylenepenta-1,5-dioate
106471-98-1

diethyl 2,2-dimethyl-4-methylenepenta-1,5-dioate

C

diethyl 3-carbethoxy-2,2,3,5,5-pentamethylhexa-1,6-dioate
127599-82-0

diethyl 3-carbethoxy-2,2,3,5,5-pentamethylhexa-1,6-dioate

D

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
With dimanganese decacarbonyl In tetrahydrofuran for 0.5h; Irradiation; or CDCl3; Further byproducts given;A 45 % Chromat.
B 5 % Chromat.
C 13%
D 17 % Chromat.
ethyl 2-bromoisobutyrate
600-00-0

ethyl 2-bromoisobutyrate

benzophenone
119-61-9

benzophenone

A

ethyl 2,2-dimethyl-3-oxobutanoate
597-04-6

ethyl 2,2-dimethyl-3-oxobutanoate

B

diethyl 2,2,3,3-tetramethylsuccinate
33367-54-3

diethyl 2,2,3,3-tetramethylsuccinate

C

Ethyl 3-hydroxy-2,2-dimethyl-3,3-diphenylpropanoate
59697-75-5

Ethyl 3-hydroxy-2,2-dimethyl-3,3-diphenylpropanoate

D

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
With tetrabutylammonium tetrafluoroborate; zinc dibromide; zinc In acetonitrile Ambient temperature;A n/a
B n/a
C 10%
D n/a
dimethylketene
598-26-5

dimethylketene

ethanol
64-17-5

ethanol

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

ethyl 2,2-dimethyl-3-oxobutanoate
597-04-6

ethyl 2,2-dimethyl-3-oxobutanoate

diethyl ether
60-29-7

diethyl ether

sodium ethanolate
141-52-6

sodium ethanolate

A

2,2-dimethyl-3,5-dioxo-hexanoic acid ethyl ester
26823-10-9

2,2-dimethyl-3,5-dioxo-hexanoic acid ethyl ester

B

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

diethyl ether
60-29-7

diethyl ether

ethyl 3-hydroxy-2,2-dimethyl-3-phenylpropanoate
52178-65-1, 133270-73-2, 35022-34-5

ethyl 3-hydroxy-2,2-dimethyl-3-phenylpropanoate

sodium ethanolate
141-52-6

sodium ethanolate

A

benzoic acid
65-85-0

benzoic acid

B

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

C

benzyl alcohol
100-51-6

benzyl alcohol

ethanol
64-17-5

ethanol

5-methyl-hexane-2,4-dione 2-enol tautomer
63289-89-4

5-methyl-hexane-2,4-dione 2-enol tautomer

A

acetone
67-64-1

acetone

B

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
Geschwindigkeit;
methyl 2,2-dimethyl-3-oxobutanoate
38923-57-8

methyl 2,2-dimethyl-3-oxobutanoate

sodium ethanolate
141-52-6

sodium ethanolate

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

ethyl 3-hydroxy-2,2-dimethylbutanoate
7505-94-4

ethyl 3-hydroxy-2,2-dimethylbutanoate

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
With aluminum oxide at 325℃;
ethyl 2-ethyl-4-methyl-3-oxopentanoate
54285-47-1

ethyl 2-ethyl-4-methyl-3-oxopentanoate

benzoic acid ethyl ester
93-89-0

benzoic acid ethyl ester

A

2-benzoyl-butyric acid ethyl ester
24346-56-3

2-benzoyl-butyric acid ethyl ester

B

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
at 145℃; Na-Verbindung;
2-isobutyryl-4-methyl-glutaric acid diethyl ester
857793-16-9

2-isobutyryl-4-methyl-glutaric acid diethyl ester

sodium ethanolate
141-52-6

sodium ethanolate

A

diethyl 2-methylglutarate
18545-83-0

diethyl 2-methylglutarate

B

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
at 115 - 120℃;
aluminum ethoxide
555-75-9

aluminum ethoxide

benzaldehyde
100-52-7

benzaldehyde

isobutyraldehyde
78-84-2

isobutyraldehyde

A

benzyl 2-methylpropanoate
103-28-6

benzyl 2-methylpropanoate

B

isobutyl benzoate
120-50-3

isobutyl benzoate

C

benzoic acid benzyl ester
120-51-4

benzoic acid benzyl ester

D

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
Produkt 5:Isobutylisobutyrat;
ethyl acetate
141-78-6

ethyl acetate

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
With sodium; methyl iodide
1-propylmagnesium chloride
2234-82-4

1-propylmagnesium chloride

2,2-dimethylmalonic acid diethyl ester
1619-62-1

2,2-dimethylmalonic acid diethyl ester

A

n-propyl isopropyl ketone
7379-12-6

n-propyl isopropyl ketone

B

4-heptanone
123-19-3

4-heptanone

C

heptan-4-ol
589-55-9

heptan-4-ol

D

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
Produkt 5: Tripropylcarbinol; Produkt 6: 5.5-Dimethyl-nonandiol-(4.6);
methylmagnesium iodide

methylmagnesium iodide

2,2-dimethylmalonic acid diethyl ester
1619-62-1

2,2-dimethylmalonic acid diethyl ester

A

2,3,3,4-tetramethylpentane-2,4-diol
19424-43-2

2,3,3,4-tetramethylpentane-2,4-diol

B

3-hydroxy-2,2,3-trimethyl-butyric acid ethyl ester
62817-86-1

3-hydroxy-2,2,3-trimethyl-butyric acid ethyl ester

C

acetone
67-64-1

acetone

D

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

propylmagnesium iodide
10557-57-0

propylmagnesium iodide

2,2-dimethylmalonic acid diethyl ester
1619-62-1

2,2-dimethylmalonic acid diethyl ester

A

4-heptanone
123-19-3

4-heptanone

B

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

2,2-dimethylmalonic acid diethyl ester
1619-62-1

2,2-dimethylmalonic acid diethyl ester

phenylmagnesium iodide

phenylmagnesium iodide

A

benzophenone
119-61-9

benzophenone

B

biphenyl
92-52-4

biphenyl

C

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

2,2-dimethylmalonic acid diethyl ester
1619-62-1

2,2-dimethylmalonic acid diethyl ester

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
With diethyl ether; sodium
With hydrogen; platinum at 200℃;
((S)-3-Iodo-2-methyl-propoxymethoxymethyl)-benzene
159751-61-8

((S)-3-Iodo-2-methyl-propoxymethoxymethyl)-benzene

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

(R)-5-Benzyloxymethoxy-2,2,4-trimethyl-pentanoic acid ethyl ester
159751-62-9

(R)-5-Benzyloxymethoxy-2,2,4-trimethyl-pentanoic acid ethyl ester

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran100%
3-methoxy-benzaldehyde
591-31-1

3-methoxy-benzaldehyde

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

ethyl 3-hydroxy-3-(3-methoxyphenyl)-2,2-dimethylpropanoate
602304-70-1, 293769-53-6

ethyl 3-hydroxy-3-(3-methoxyphenyl)-2,2-dimethylpropanoate

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: 3-methoxy-benzaldehyde In tetrahydrofuran at -78℃; for 1.5h;
100%
2-bromomethyl-1,3,4-trimethoxynaphthalene
777075-01-1

2-bromomethyl-1,3,4-trimethoxynaphthalene

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

ethyl 2,2-dimethyl-3-(1,3,4-trimethoxynaphthalen-2-yl)propanoate
777075-05-5

ethyl 2,2-dimethyl-3-(1,3,4-trimethoxynaphthalen-2-yl)propanoate

Conditions
ConditionsYield
With lithium diisopropyl amide100%
Stage #1: Ethyl isobutyrate With n-butyllithium; lithium diisopropyl amide In tetrahydrofuran; hexane at -80℃; Inert atmosphere;
Stage #2: 3-bromomethyl-1,2,4-trimethoxynaphthalene In tetrahydrofuran; hexane at -80 - 20℃; Inert atmosphere;
5.5 g
4-Fluorobenzyl bromide
459-46-1

4-Fluorobenzyl bromide

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

3-(4-Fluorophenyl)-2,2-dimethyl-propionic Acid Ethyl Ester
676621-95-7

3-(4-Fluorophenyl)-2,2-dimethyl-propionic Acid Ethyl Ester

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h;
Stage #2: 4-Fluorobenzyl bromide In tetrahydrofuran at -78 - 20℃; for 18h;
100%
Stage #1: Ethyl isobutyrate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h;
Stage #2: 4-Fluorobenzyl bromide In tetrahydrofuran for 18.0833h;
99%
3-phenyl-propionaldehyde
104-53-0

3-phenyl-propionaldehyde

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

ethyl 3-hydroxy-2,2-dimethyl-5-phenylpentanoate
133270-74-3, 133270-75-4, 134924-29-1

ethyl 3-hydroxy-2,2-dimethyl-5-phenylpentanoate

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: 3-phenyl-propionaldehyde In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere;
100%
bromoundecane
693-67-4

bromoundecane

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

ethyl 2,2-dimethyltridecanoate

ethyl 2,2-dimethyltridecanoate

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1h;
Stage #2: bromoundecane In tetrahydrofuran; hexane at 20℃;
100%
Stage #1: Ethyl isobutyrate With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1h;
Stage #2: bromoundecane In tetrahydrofuran; hexane at 20℃;
100%
1-Bromo-2-butyne
3355-28-0

1-Bromo-2-butyne

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

ethyl 2,2-dimethylhex-4-ynoate
116252-14-3

ethyl 2,2-dimethylhex-4-ynoate

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 0.166667h;
Stage #2: 1-Bromo-2-butyne In tetrahydrofuran; hexane at -78℃; for 0.75h;
99%
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide In tetrahydrofuran at -10℃;95%
With lithium diisopropyl amide76%
Stage #1: Ethyl isobutyrate With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 0.75h; Inert atmosphere;
Stage #2: 1-Bromo-2-butyne In tetrahydrofuran; hexane at -78 - 20℃; for 0.4h; Inert atmosphere;
61%
2-(2-Hydroxy-1,1-bis-hydroxymethyl-ethylamino)-ethanesulfonic acid (1R,3aR,4S,7aR)-1-((R)-3-iodo-1-methyl-propyl)-7a-methyl-octahydro-inden-4-yl ester

2-(2-Hydroxy-1,1-bis-hydroxymethyl-ethylamino)-ethanesulfonic acid (1R,3aR,4S,7aR)-1-((R)-3-iodo-1-methyl-propyl)-7a-methyl-octahydro-inden-4-yl ester

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

(R)-5-{(1R,3aR,4S,7aR)-4-[2-(2-Hydroxy-1,1-bis-hydroxymethyl-ethylamino)-ethanesulfonyloxy]-7a-methyl-octahydro-inden-1-yl}-2,2-dimethyl-hexanoic acid ethyl ester

(R)-5-{(1R,3aR,4S,7aR)-4-[2-(2-Hydroxy-1,1-bis-hydroxymethyl-ethylamino)-ethanesulfonyloxy]-7a-methyl-octahydro-inden-1-yl}-2,2-dimethyl-hexanoic acid ethyl ester

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 2h;99%
Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

1-iodo-2-(triethylsilyloxy)ethane
371154-03-9

1-iodo-2-(triethylsilyloxy)ethane

2,2-dimethyl-4-triethylsilanyloxy-butyric acid ethyl ester
886220-98-0

2,2-dimethyl-4-triethylsilanyloxy-butyric acid ethyl ester

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 0.333333h;
Stage #2: 1-iodo-2-(triethylsilyloxy)ethane In tetrahydrofuran; hexane cooling;
99%
With lithium diisopropyl amide In tetrahydrofuran at -78 - 20℃;
1,2,3-trimethoxybenzene
621-23-8

1,2,3-trimethoxybenzene

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

1-(2-methylpropyl)-2,4,6-trimethoxybenzene
916916-55-7

1-(2-methylpropyl)-2,4,6-trimethoxybenzene

Conditions
ConditionsYield
With dimethylethylsilane; (μ3,η2,η3,η5-acenaphthylene)Ru3(CO)7 at 20℃; for 5h; Inert atmosphere; Neat (no solvent);99%
phenylacetonitrile
140-29-4

phenylacetonitrile

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

4-methyl-3-oxo-2-phenyl-pentanenitrile
32039-89-7

4-methyl-3-oxo-2-phenyl-pentanenitrile

Conditions
ConditionsYield
With potassium 2-methylbutan-2-olate In tetrahydrofuran at 60℃; for 1h;98.4%
Stage #1: Ethyl isobutyrate With potassium tert-butylate In tetrahydrofuran; water
Stage #2: phenylacetonitrile In tetrahydrofuran; water at 20℃; for 0.5h;
75%
Stage #1: phenylacetonitrile With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃;
Stage #2: Ethyl isobutyrate In tetrahydrofuran; mineral oil at 60℃; for 2h;
Stage #3: With hydrogenchloride In tetrahydrofuran; water; mineral oil
19%
With diethyl ether; ethanol; potassium ethoxide
With lithium hexamethyldisilazane In tetrahydrofuran at 0 - 29℃; for 1h; Inert atmosphere; Schlenk technique;
benzaldehyde
100-52-7

benzaldehyde

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

ethyl 3-hydroxy-2,2-dimethyl-3-phenylpropanoate
52178-65-1, 133270-73-2, 35022-34-5

ethyl 3-hydroxy-2,2-dimethyl-3-phenylpropanoate

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: benzaldehyde In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
98%
With n-butyllithium; diisopropylamine THF, -78 deg C; 1.) 50 min, 2.) 5 min; Yield given. Multistep reaction;
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Diethyl 2,2-dimethyl-3-(trifluoromethyl)glutarate

Diethyl 2,2-dimethyl-3-(trifluoromethyl)glutarate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 1.0 h;98%
6,6'-Dibromo-2,2'-bipyridine
49669-22-9

6,6'-Dibromo-2,2'-bipyridine

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

6,6'-bis(1-ethoxycarbonyl-1-methylethyl)-[2,2']bipyridinyl
455317-76-7

6,6'-bis(1-ethoxycarbonyl-1-methylethyl)-[2,2']bipyridinyl

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 0.666667h;
Stage #2: 6,6'-Dibromo-2,2'-bipyridine In tetrahydrofuran; hexane at -78℃; for 0.166667h; Irradiation;
98%
4-bromobenzenecarbonitrile
623-00-7

4-bromobenzenecarbonitrile

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

ethyl 2-(4-cyanophenyl)-2-methylpropanoate
1273587-21-5

ethyl 2-(4-cyanophenyl)-2-methylpropanoate

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex In tetrahydrofuran at 25℃; Inert atmosphere;
Stage #2: 4-bromobenzenecarbonitrile With palladium diacetate In tetrahydrofuran at 50℃; for 9h; Inert atmosphere;
98%
N-(benzylidene)-p-methylbenzenesulfonamide
51608-60-7

N-(benzylidene)-p-methylbenzenesulfonamide

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

2,2-dimethyl-3-phenyl-3-(toluene-4-sulfonylamino)-propionic acid ethyl ester

2,2-dimethyl-3-phenyl-3-(toluene-4-sulfonylamino)-propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 1h;
Stage #2: N-(benzylidene)-p-methylbenzenesulfonamide In tetrahydrofuran; hexane for 2h;
98%
4-iodo-1-butynyltrimethylsilane
41423-29-4

4-iodo-1-butynyltrimethylsilane

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

ethyl 2,2-dimethyl-6-(trimethylsilyl) hex-5-ynoate

ethyl 2,2-dimethyl-6-(trimethylsilyl) hex-5-ynoate

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 0℃; for 0.5h; Inert atmosphere;
Stage #2: 4-iodo-1-butynyltrimethylsilane In tetrahydrofuran; hexane at 20℃; Inert atmosphere;
98%
Stage #1: Ethyl isobutyrate With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 0℃; for 1.16667h; Corey-Fuchs Alkyne Synthesis; Inert atmosphere;
Stage #2: 4-iodo-1-butynyltrimethylsilane In tetrahydrofuran; hexane at -78 - 20℃; for 2h; Inert atmosphere;
88%
2-bromo-3-(bromomethyl)benzonitrile
1086429-87-9

2-bromo-3-(bromomethyl)benzonitrile

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

C14H16BrNO2
1269411-32-6

C14H16BrNO2

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With n-butyllithium; diisopropylamine In tetrahydrofuran at -20℃; for 0.916667h; Inert atmosphere;
Stage #2: 2-bromo-3-(bromomethyl)benzonitrile In tetrahydrofuran at -20℃; for 0.75h;
97.5%
2-methylpropenal
78-85-3

2-methylpropenal

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

ethyl 3-hydroxy-2,2,4-trimethylpent-4-enoate

ethyl 3-hydroxy-2,2,4-trimethylpent-4-enoate

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 0.833333h;
Stage #2: 2-methylpropenal In tetrahydrofuran; hexane at -78℃; for 0.166667h; Further stages.;
97%
Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

3-bromo-1-phenyl-1-propenyl bromide
4392-24-9

3-bromo-1-phenyl-1-propenyl bromide

(E)-ethyl 2,2-dimethyl-5-phenylpent-4-enoate
72524-20-0

(E)-ethyl 2,2-dimethyl-5-phenylpent-4-enoate

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With lithium diisopropyl amide In tetrahydrofuran at -5℃; for 0.5h; Inert atmosphere;
Stage #2: 3-phenylprop-2-en-1-yl bromide In tetrahydrofuran at -50 - 20℃; for 18h; Inert atmosphere;
97%
Stage #1: Ethyl isobutyrate With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -50 - -5℃; for 1h; Inert atmosphere;
Stage #2: 3-phenylprop-2-en-1-yl bromide In tetrahydrofuran; hexane at -50 - 20℃; for 10h; Inert atmosphere;
94%
2-phenylethanol
60-12-8

2-phenylethanol

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

phenylethyl isobutyrate
103-48-0

phenylethyl isobutyrate

Conditions
ConditionsYield
With iron(III)-acetylacetonate In n-heptane at 105℃; for 11h; Inert atmosphere;97%
N-(4-methoxybenzylidene)-p-toluenesulfonamide
14674-38-5

N-(4-methoxybenzylidene)-p-toluenesulfonamide

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

C21H27NO5S

C21H27NO5S

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 1h;
Stage #2: N-(4-methoxybenzylidene)-p-toluenesulfonamide In tetrahydrofuran; hexane for 2h;
97%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene
31469-16-6

1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.333333h;
Stage #2: chloro-trimethyl-silane In tetrahydrofuran; hexane at 20℃;
96%
With lithium diisopropyl amide In tetrahydrofuran95%
Stage #1: Ethyl isobutyrate With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: chloro-trimethyl-silane With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone In tetrahydrofuran; hexane at -78 - 20℃; for 12.5h; Inert atmosphere;
83%
N-cinnamylidene-p-anisidine
80542-40-1

N-cinnamylidene-p-anisidine

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

1-(4-Methoxy-phenyl)-3,3-dimethyl-4-phenyl-3,4-dihydro-1H-pyridin-2-one

1-(4-Methoxy-phenyl)-3,3-dimethyl-4-phenyl-3,4-dihydro-1H-pyridin-2-one

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran for 12h; Ambient temperature;96%
(4S,5S)-4,5-dimethoxymethyl-2-(N-p-methoxyphenyl)iminomethyl-2-methyl-1,3-dioxolane
146726-49-0

(4S,5S)-4,5-dimethoxymethyl-2-(N-p-methoxyphenyl)iminomethyl-2-methyl-1,3-dioxolane

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

(4S)-4-<(4S,5S)-4,5-dimethoxymethyl-2-methyl-1,3-dioxolan-2-yl>-1-p-methoxyphenyl-3,3-dimethyl-2-azetidinone
139308-01-3

(4S)-4-<(4S,5S)-4,5-dimethoxymethyl-2-methyl-1,3-dioxolan-2-yl>-1-p-methoxyphenyl-3,3-dimethyl-2-azetidinone

Conditions
ConditionsYield
With lithium diisopropyl amide Mechanism; Product distribution; multistep reaction; other metal ester enolates; enantioselectivity;96%
With lithium diisopropyl amide 1.) DME, -78 deg C, 15 min, 2.) DME, r.t, 12 h; Yield given. Multistep reaction;
2-bromo-2',4'-difluoroacetophenone
102429-07-2

2-bromo-2',4'-difluoroacetophenone

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

3-(2,4-difluorophenyl)-3,4-epoxy-2,2-dimethylbutanoic acid ethyl ester
145793-68-6

3-(2,4-difluorophenyl)-3,4-epoxy-2,2-dimethylbutanoic acid ethyl ester

Conditions
ConditionsYield
With n-butyllithium; ammonium chloride; sodium hydrogencarbonate; lithium diisopropyl amide In tetrahydrofuran; hexane; water96%
o-chloro-N-tosylbenzaldimine
135822-90-1

o-chloro-N-tosylbenzaldimine

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

C20H24ClNO4S

C20H24ClNO4S

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 1h;
Stage #2: o-chloro-N-tosylbenzaldimine In tetrahydrofuran; hexane for 2h;
96%
(Z,Z,Z)-1-Bromooctadeca-9,12,15-triene
64875-27-0

(Z,Z,Z)-1-Bromooctadeca-9,12,15-triene

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

C24H42O2

C24H42O2

Conditions
ConditionsYield
Stage #1: Ethyl isobutyrate With lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at -78℃;
Stage #2: (Z,Z,Z)-1-Bromooctadeca-9,12,15-triene In tetrahydrofuran; n-heptane; ethylbenzene at -78 - 20℃; Inert atmosphere;
96%

97-62-1Relevant articles and documents

-

Hammond,Fox

, p. 1918,1920 (1964)

-

Selective C-C Bond Scission of Ketones via Visible-Light-Mediated Cerium Catalysis

Chen, Yilin,Du, Jianbo,Zuo, Zhiwei

supporting information, p. 266 - 279 (2020/01/08)

-

A methodical selection process for the development of ketones and esters as bio-based replacements for traditional hydrocarbon solvents

Byrne, Fergal P.,Forier, Bart,Bossaert, Greet,Hoebers, Charly,Farmer, Thomas J.,Hunt, Andrew J.

supporting information, p. 4003 - 4011 (2018/09/11)

A "top down" approach to the development of sustainable, greener, low-polarity solvents is presented. Methyl butyrate, ethyl isobutyrate, methyl pivalate and pinacolone were identified as potential target solvents from trends in Hansen solubility parameters and known physical properties. Solubility, flammability and physical properties were determined which showed their potential to replace traditional, hazardous, volatile, non-polar solvents such as toluene. Each new candidate then demonstrated their suitability to replace these traditional solvents in solubility tests, despite being esters and ketones, each candidate demonstrated their similarity to traditional volatile non-polar solvents in terms of their solubility properties by their ability to dissolve natural rubber, a particularly low-polarity solute. This was reinforced by their performance in a model Menschutkin reaction and a radical-initiated polymerisation for the production of pressure-sensitive adhesives, where their performance was found to be similar to that of toluene. Importantly, a preliminary toxicity test (Ames test) suggested non-mutagenicity in all candidates. Each of the four candidates can be synthesised via a catalytic route from potentially renewable resources, thus enhancing their green credentials.

NANOEMULSIONS

-

Page/Page column 20, (2016/09/22)

An oil-in-water emulsion comprises an emulsifier which is a non-gelled branched polymer (e.g. a branched vinyl polymer), wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. This is useful in, for example, facilitating the carrying of hydrophobic materials within aqueous systems, to enhance oral drug delivery. The oil-in-water emulsion may be prepared by mixing an oil phase with an aqueous phase in the presence of an emulsifier, wherein said emulsifier is a non-gelled branched polymer, wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. The oil phase may comprise a further solvent which is miscible with the oil, said solvent being allowed to evaporate to produce the final emulsion.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 97-62-1