98050-62-5

Basic information

• Product Name: 5-(tert-butoxycarbonyl)-4-(m-chlorophenyl)-6-hydroxy-2,6-dimethyl-1,4,5,6-tetrahydropyrimidine
• Synonyms: 5-(tert-butoxycarbonyl)-4-(m-chlorophenyl)-6-hydroxy-2,6-dimethyl-1,4,5,6-tetrahydropyrimidine
• CAS NO: 98050-62-5
• Molecular Weight: 338.834
• Mol File: 98050-62-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(tert-butoxycarbonyl)-4-(m-chlorophenyl)-6-hydroxy-2,6-dimethyl-1,4,5,6-tetrahydropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(tert-butoxycarbonyl)-4-(m-chlorophenyl)-6-hydroxy-2,6-dimethyl-1,4,5,6-tetrahydropyrimidine(98050-62-5)
• EPA Substance Registry System: 5-(tert-butoxycarbonyl)-4-(m-chlorophenyl)-6-hydroxy-2,6-dimethyl-1,4,5,6-tetrahydropyrimidine(98050-62-5)

Safety Data

• Hazardous Substances Data: 98050-62-5(Hazardous Substances Data)

Upstream product

• 124-42-5 acetamidine hydrochloride 
• 98050-57-8 2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid tert-butyl ester 

Downstream Products

• 98050-74-9 5-(tert-butoxycarbonyl)-4-(m-chlorophenyl)-2,6-dimethyl-1,4(3,4)-dihydropyrimidine 

Relevant articles and documents

Synthesis of Novel Dihydropyrimidines and Tetrahydropyrimidines

Condensation of alkyl 2-acetyl-3-aryl-2-propenoate with acetamidine, benzamidine, guanidine, or 1,1-dimethylguanidine followed by dehydration of the resulting compound 2 with p-TsOH or Al2O3 gave 1,4(3,4)-dihydropyrimidine 3.Regioselective alkoxycarbonylation, acylation, and alkylation of compound 3 with alkyl chloroformate, acyl halide, or alkyl halide in the presence of NaH afforded the series of novel N-substituted 3,4-dihydropyrimidines 4, 5, and 6 in good yield.Stereoselective NaBH4 reduction of the 3,4-dihydropyrimidine hydrochloride 4 provided a singlestereoisomer of 1,2,3,4-tetrahydropyrimidine 7 whose stereochemistry was assigned as cis by X-ray crystallographic analysis.Conversely, the same reduction of the HCl salts of 3 or 6 gave a cis-trans mixture of tetrahydropyrimidines 8.