98647-23-5

Basic information

• Product Name: Z-SER(BZL)-OSU
• Synonyms: Z-SERINE(BZL)-OSU;Z-SER(BZL)-OSU;Z-O-BENZYL-L-SERINE-HYDROXYSUCCINIMIDE ESTER;Z-O-BENZYL-L-SERINE N-HYDROXYSUCCINIMIDE ESTER;Z-O-BENZYL-L-SERINE-HYDROXYSUCCINIMIDESTER;Z-L-Ser(Bzl)-OSu;Z-O-benzyl-L-serine N-hydroxysuccinimide ester99%
• CAS NO: 98647-23-5
• Molecular Formula: C₂₂H₂₂N₂O₇
• Molecular Weight: 426.42
• Mol File: 98647-23-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-SER(BZL)-OSU(CAS DataBase Reference)
• NIST Chemistry Reference: Z-SER(BZL)-OSU(98647-23-5)
• EPA Substance Registry System: Z-SER(BZL)-OSU(98647-23-5)

Safety Data

• Hazardous Substances Data: 98647-23-5(Hazardous Substances Data)

Usage

General Description

The chemical "Z-SER(BZL)-OSU" is a synthetic peptide derivative used in chemical biology and drug development research. It is a modified form of the peptide serine, with a benzoyl group (BZL) attached to the side chain. This modification allows for specific targeting and labeling of proteins that contain serine residues, enabling researchers to study their function and interactions in biological systems. "Z-SER(BZL)-OSU" has potential applications in the development of new pharmaceuticals and biotechnology products, as well as in the study of protein-protein interactions and signaling pathways in cells.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 20806-43-3 Z-Ser(Bzl)-OH 
• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 
• 75315-63-8 N-(benzyloxycarbonyl)succinimide 
• 4726-96-9 O-Benzyl-L-serine 

Downstream Products

• 219917-69-8 {(S)-2-Benzyloxy-1-[((3aR,4S,5aR,9aR,9bR)-2,2,4,8,8-pentamethyl-tetrahydro-1,3,7,9-tetraoxa-5-aza-cyclopenta[a]naphthalen-5a-ylmethyl)-carbamoyl]-ethyl}-carbamic acid benzyl ester 
• 226699-19-0 (S)-N-benzyloxycarbonyl O-benzyl serinamide 
• 156727-89-8 (R)-2-benzyloxycarbonylamino-1-benzyloxymethyl-4-aminopropane 
• 1027896-97-4 (R)-2-Benzyloxymethyl-4-(3,4,5-trimethoxy-benzoyl)-3,4-dihydro-2H-pyrazine-1-carboxylic acid benzyl ester 
• 1026241-46-2 {(R)-2-Benzyloxy-1-[(2,2-diethoxy-ethylamino)-methyl]-ethyl}-carbamic acid benzyl ester 
• 1026327-57-0 Methanesulfonic acid (S)-3-benzyloxy-2-benzyloxycarbonylamino-propyl ester 
• 156727-88-7 (R)-1-benzyloxycarbonyl-2-benzyloxymethylazirizine 
• 503129-98-4 5-(2-(6-(O-benzyl-L-serinamido)hexylamino)-2-oxoethyl)-2'-deoxyuridine 5'-triphosphate 
• 885109-37-5 5-(2-(6-(N^α-carbobenzoxy-O-benzyl-L-serinamido)hexylamino)-2-oxoethyl)-2'-dUTP 
• 58578-42-0 (R)-benzyl 1-(benzyloxy)-3-hydroxypropan-2-ylcarbamate 

Relevant articles and documents

Direct PCR amplification of various modified DNAs having amino acids: Convenient preparation of DNA libraries with high-potential activities for in vitro selection

We synthesized modified 2′-deoxyuridine triphosphates bearing amino acids at the C5 position and investigated their substrate properties for KOD Dash DNA polymerase during polymerase chain reaction (PCR). PCR using C5-modified dUTP having an amino acyl group (arginyl, histidyl, lysyl, phenylalanyl, tryptophanyl, leucyl, prolyl, glutaminyl, seryl, O-benzyl seryl or threonyl group) gave the corresponding full-length PCR products in good yield. Although dUTP analogues bearing aspartyl, glutamyl or cysteinyl were found to be poor substrates for PCR catalyzed by KOD Dash DNA polymerase, optimization of the reaction conditions resulted in substantial generation of full-length product. In the case of reaction using dUTP analogue having a cysteinyl group, addition of a reducing agent improved the reaction yield. Thus, PCRs using KOD Dash DNA polymerase together with amino acyl dUTP provide convenient and efficient preparation of various modified DNA libraries with potential protein-like activities.

Synthesis and platelet-activating factor (PAF)-antagonistic activities of trisubstituted piperazine derivatives

2- or 3-Substituted 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclobepten-8- ylcarbonyl)-4-(3,4,5-trimethoxybenzoyl)- and 4-(3,4,5- trimethoxybenzyl)piperazines (2a - s, 3a, b) were prepared and evaluated for antagonistic activities against platelet-activating