Welcome to LookChem.com Sign In|Join Free

CAS

  • or

987-24-6

Post Buying Request

987-24-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

987-24-6 Usage

Chemical Properties

White Solid

Originator

Celestone Soluspan,Schering,US,1965

Uses

Different sources of media describe the Uses of 987-24-6 differently. You can refer to the following data:
1. Betamethasone acetate (BA)
2. CORTICOSTEROID

Manufacturing Process

The synthesis is long and complex. For brevity, only the last steps are given here. Refer to the patents cited below for full details. Preparation of 9α-Bromo-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnene-3,20- Dione 21-Acetate: To a mixture of 620 mg of 17α,21-dihydroxy-16β-methyl- 4,9(11)-pregnadiene-3,20-dione 21-acetate and 330 mg of Nbromosuccinimide in 10 ml of dioxane and 3.2 ml of water cooled to 10°C was added 1.8 ml of cold 1 M aqueous perchloric acid. The mixture was stirred at 15°C for 3 hours. Excess N-bromosuccinimide was destroyed by addition of aqueous sodium thiosulfate and most of the dioxane was removed in vacuo. About 30 ml of water was added and crystalline bromohydrin, 9α-bromo- 11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate, was filtered, washed with water, and dried in air. Preparation of 9β,11β-Epoxy-17α-21-Dihydroxy-16β-Methyl-4-Pregnene-3,20- Dione 21-Acetate: To a stirred solution of 100 mg of the 9α-bromo- 11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate in 3 ml of tetrahydrofuran and 1 ml of methanol under nitrogen was added 1.02 ml of 0.215N methanolic sodium methoxide. After 10 minutes at 25°C, 0.2 ml of acetic acid was added and the methanol removed in vacuo. The residue was acetylated with 1.00 ml of pyridine and 0.5 ml of acetic anhydride at 60°C for 70 minutes. The mixture was taken to dryness in vacuo, water added, and the product extracted into chloroform. The residue was crystallized from etheracetone to give pure 9β,11β-epoxy-17α,21-dihydroxy-16β-methyl-4-pregnene- 3,20-dione 21-acetate. Preparation of 9α-Fluoro-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnene-3,20- Dione 21-Acetate: To a solution of 200 mg of 9β,11β-epoxy-17α,21-dihydroxy- 16β-methyl-4-pregnene-3,20-dione 21-acetate in 2 ml of chloroform and 2 ml of tetrahydrofuran in a polyethylene bottle at -60°C was added 2 ml of a 2:1 (by weight) mixture of anhydrous hydrogen fluoride and tetrahydrofuran. After 4 hours at -10°C the mixture was cooled to -60°C and cautiously added to a stirred mixture of 30 ml or 25% aqueous potassium carbonate and 25 ml of chloroform kept at -5°C. The aqueous phase was further extracted with chloroform and the latter phase washed with water and dried over magnesium sulfate. The residue on crystallization from acetone-ether gave pure 9α-fluoro- 11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate. Preparation of 9α-Fluoro-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnadiene- 3,20-Dione 21-Acetate 100 mg of 9α-fluoro-11β,17α,21-trihydroxy-16β- methyl-4-pregnene-3,20-dione 21-acetate was treated with selenium dioxide to produce the corresponding 9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-4- pregnadiene-3,20-dione 21-acetate. Alternately, Bacillus sphaericus may be utilized.

Check Digit Verification of cas no

The CAS Registry Mumber 987-24-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,8 and 7 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 987-24:
(5*9)+(4*8)+(3*7)+(2*2)+(1*4)=106
106 % 10 = 6
So 987-24-6 is a valid CAS Registry Number.
InChI:InChI=1/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17-,18-,19-,21-,22-,23-,24-/m0/s1

987-24-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Sigma-Aldrich

  • (B1030000)  Betamethasone acetate  European Pharmacopoeia (EP) Reference Standard

  • 987-24-6

  • B1030000

  • 1,880.19CNY

  • Detail
  • USP

  • (1067001)  Betamethasone acetate  United States Pharmacopeia (USP) Reference Standard

  • 987-24-6

  • 1067001-500MG

  • 4,662.45CNY

  • Detail

987-24-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name betamethasone acetate

1.2 Other means of identification

Product number -
Other names Betamethasone 21-acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:987-24-6 SDS

987-24-6Synthetic route

21-acetoxy-9,11β-epoxy-17-hydroxy-16β-methyl-9β-pregna-1,4-diene-3,20-dione
912-38-9, 2884-51-7, 14622-51-6, 98573-86-5

21-acetoxy-9,11β-epoxy-17-hydroxy-16β-methyl-9β-pregna-1,4-diene-3,20-dione

betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

Conditions
ConditionsYield
With tetrahydrofuran; chloroform; hydrogen fluoride
9β,11β-epoxy-17α,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate

9β,11β-epoxy-17α,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate

betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

Conditions
ConditionsYield
With hydrogen fluoride In chloroform
(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2,2-Diiodo-acetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one
37414-01-0

(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2,2-Diiodo-acetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

potassium acetate
127-08-2

potassium acetate

betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

Conditions
ConditionsYield
With acetic acid In water; acetone for 3h; Heating;180 mg
16α,17α-epoxy-3β-hydroxy-5α-pregn-9(11)-en-20-one
884488-47-5

16α,17α-epoxy-3β-hydroxy-5α-pregn-9(11)-en-20-one

betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: 95 percent / pyridine / 20 °C
2.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C
3.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C
4.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating
4.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C
5.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling
5.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling
6.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
7.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
8.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
View Scheme
16β-methyl-9β,11β-epoxy-17α-hydroxy-1,4-pregnadiene-3,20-dione
37413-99-3

16β-methyl-9β,11β-epoxy-17α-hydroxy-1,4-pregnadiene-3,20-dione

betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
2: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
3: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
View Scheme
hecogenin acetate
915-35-5

hecogenin acetate

betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: 72 percent / m-iodoxybenzoic acid; diphenyl diselenide / toluene / 12 h / Heating
2.1: hydrazine hydrate / ethane-1,2-diol / 1 h / Heating
2.2: 95 percent / potassium hydroxide / ethane-1,2-diol; H2O / 5 h / 195 - 197 °C
3.1: pyridine; ammonium chloride / 125 - 135 °C
3.2: acetic acid; chromium trioxide / H2O; 1,2-dichloro-ethane / 1 h / 20 °C
3.3: 57 percent / aluminium oxide / benzene / 2 h
4.1: 91.7 percent / hydrogen peroxide; sodium hydroxide / methanol / 2 h / 20 °C
5.1: 95 percent / pyridine / 20 °C
6.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C
7.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C
8.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating
8.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C
9.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling
9.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling
10.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
11.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
12.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
View Scheme
17α,21-dihydroxy-16β-methyl-1,4,9(11)-pregnatriene-3,20-dione 21-acetate
910-99-6

17α,21-dihydroxy-16β-methyl-1,4,9(11)-pregnatriene-3,20-dione 21-acetate

betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hypobromous acid; sodium acetate
2: CHCl3; THF; HF
View Scheme
betamethasone
378-44-9

betamethasone

acetic anhydride
108-24-7

acetic anhydride

betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

Conditions
ConditionsYield
With sodium acetate In tetrahydrofuran; acetone at 40℃; for 3h; Inert atmosphere;
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

(11β,16β)-9-fluoro-16-methyl-3,20-dioxo-11,17-bis[(trimethylsilyl)oxy]pregna-1,4-dien-21-yl acetate
733766-12-6

(11β,16β)-9-fluoro-16-methyl-3,20-dioxo-11,17-bis[(trimethylsilyl)oxy]pregna-1,4-dien-21-yl acetate

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h;99%
betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

betamethasone
378-44-9

betamethasone

Conditions
ConditionsYield
With methanol; sodium methylate at 25℃; for 4h;90%
betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

benzoyl chloride
98-88-4

benzoyl chloride

9α-fluoro-3,11β,17α,21-tetrahydroxy-16β-methyl-1,3,5-pregnatriene-20-one 21-acetate 3-benzoate
59860-91-2

9α-fluoro-3,11β,17α,21-tetrahydroxy-16β-methyl-1,3,5-pregnatriene-20-one 21-acetate 3-benzoate

Conditions
ConditionsYield
In pyridine at 70℃; for 18h;71%
betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

9α-fluoro-6β,11β,17α,21-tetrahydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 21-acetate
72559-76-3

9α-fluoro-6β,11β,17α,21-tetrahydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 21-acetate

Conditions
ConditionsYield
With selenium(IV) oxide In 1,4-dioxane at 80℃; for 2.5h;22%
Multi-step reaction with 2 steps
1: 71 percent / pyridine / 18 h / 70 °C
2: 58 percent / m-chloroperbenzoic acid / CHCl3 / 1 h / Ambient temperature
View Scheme
betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione
72559-90-1

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 71 percent / pyridine / 18 h / 70 °C
2: 58 percent / m-chloroperbenzoic acid / CHCl3 / 1 h / Ambient temperature
3: 61 percent / pyridine/ CF3-COOH/ 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluenesulfonate / dimethylsulfoxide; benzene / 16 h / Ambient temperature
4: 75 percent / Na2CO3 / methanol / 18 h / Ambient temperature
View Scheme
betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-propionate
72560-06-6

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-propionate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 71 percent / pyridine / 18 h / 70 °C
2: 58 percent / m-chloroperbenzoic acid / CHCl3 / 1 h / Ambient temperature
3: 61 percent / pyridine/ CF3-COOH/ 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluenesulfonate / dimethylsulfoxide; benzene / 16 h / Ambient temperature
4: 75 percent / Na2CO3 / methanol / 18 h / Ambient temperature
5: 73 percent / 1.) p-toluenesulfonic acid monohydrate; 2.) 90percent CH3COOH aq. / Ambient temperature; 1.) DMSO, 4 h; 2.) 4 h
View Scheme
betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-isobutyrate
72559-92-3

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-isobutyrate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 71 percent / pyridine / 18 h / 70 °C
2: 58 percent / m-chloroperbenzoic acid / CHCl3 / 1 h / Ambient temperature
3: 61 percent / pyridine/ CF3-COOH/ 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluenesulfonate / dimethylsulfoxide; benzene / 16 h / Ambient temperature
4: 75 percent / Na2CO3 / methanol / 18 h / Ambient temperature
5: 79 percent / 1.) p-toluenesulfonic acid monohydrate; 2.) 90percent CH3COOH aq. / Ambient temperature; 1.) DMSO, 4 h; 2.) 4 h
View Scheme
betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 21-acetate
72559-84-3

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 21-acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 71 percent / pyridine / 18 h / 70 °C
2: 58 percent / m-chloroperbenzoic acid / CHCl3 / 1 h / Ambient temperature
3: 61 percent / pyridine/ CF3-COOH/ 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluenesulfonate / dimethylsulfoxide; benzene / 16 h / Ambient temperature
View Scheme
betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-butyrate
82926-63-4

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-butyrate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 71 percent / pyridine / 18 h / 70 °C
2: 58 percent / m-chloroperbenzoic acid / CHCl3 / 1 h / Ambient temperature
3: 61 percent / pyridine/ CF3-COOH/ 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluenesulfonate / dimethylsulfoxide; benzene / 16 h / Ambient temperature
4: 75 percent / Na2CO3 / methanol / 18 h / Ambient temperature
5: 44 percent / 1.) p-toluenesulfonic acid monohydrate; 2.) 90percent CH3COOH aq. / Ambient temperature; 1.) DMSO, 4 h; 2.) 4 h
View Scheme
betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-valerate
72560-03-3

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-valerate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 71 percent / pyridine / 18 h / 70 °C
2: 58 percent / m-chloroperbenzoic acid / CHCl3 / 1 h / Ambient temperature
3: 61 percent / pyridine/ CF3-COOH/ 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluenesulfonate / dimethylsulfoxide; benzene / 16 h / Ambient temperature
4: 75 percent / Na2CO3 / methanol / 18 h / Ambient temperature
5: 41 percent / 1.) p-toluenesulfonic acid monohydrate; 2.) 90percent CH3COOH aq. / Ambient temperature; 1.) DMSO, 4 h; 2.) 4 h
View Scheme
betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 21-trimethylacetate
72559-93-4

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 21-trimethylacetate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 71 percent / pyridine / 18 h / 70 °C
2: 58 percent / m-chloroperbenzoic acid / CHCl3 / 1 h / Ambient temperature
3: 61 percent / pyridine/ CF3-COOH/ 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluenesulfonate / dimethylsulfoxide; benzene / 16 h / Ambient temperature
4: 75 percent / Na2CO3 / methanol / 18 h / Ambient temperature
5: 64 percent / pyridine / 72 h / Ambient temperature
View Scheme
betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-benzoate
72560-07-7

9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-benzoate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 71 percent / pyridine / 18 h / 70 °C
2: 58 percent / m-chloroperbenzoic acid / CHCl3 / 1 h / Ambient temperature
3: 61 percent / pyridine/ CF3-COOH/ 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluenesulfonate / dimethylsulfoxide; benzene / 16 h / Ambient temperature
4: 75 percent / Na2CO3 / methanol / 18 h / Ambient temperature
5: 29 percent / 1.) p-toluenesulfonic acid monohydrate; 2.) 90percent CH3COOH aq. / Ambient temperature; 1.) 120 h; 2.) 4 h
View Scheme
betamethasone 21-acetate
987-24-6

betamethasone 21-acetate

9α-fluoro-6,11β,17α,21-tetrahydroxy-16β-methyl-1,4,6-pregnatriene-3,20-dione 6,17,21-tripropionate
72559-33-2

9α-fluoro-6,11β,17α,21-tetrahydroxy-16β-methyl-1,4,6-pregnatriene-3,20-dione 6,17,21-tripropionate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 71 percent / pyridine / 18 h / 70 °C
2: 58 percent / m-chloroperbenzoic acid / CHCl3 / 1 h / Ambient temperature
3: 61 percent / pyridine/ CF3-COOH/ 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluenesulfonate / dimethylsulfoxide; benzene / 16 h / Ambient temperature
4: 75 percent / Na2CO3 / methanol / 18 h / Ambient temperature
5: 73 percent / 1.) p-toluenesulfonic acid monohydrate; 2.) 90percent CH3COOH aq. / Ambient temperature; 1.) DMSO, 4 h; 2.) 4 h
6: 90 percent / pyridine / 5 h / Ambient temperature
View Scheme

987-24-6Relevant articles and documents

C21 steroid 21 site acetylation process

-

Paragraph 0018-0021, (2018/11/22)

The invention discloses a C21 steroid 21 site acetylation process. C21 steroid is prednisolone, hydrocortisone, dexamethasone or betamethasone; the C21 steroid is subjected to acetylation with aceticanhydride; the acetylation of the C21 steroid with the acetic anhydride is carried out in a mixed solvent; an acetic acid alkali metal salt is adopted as a catalyst, and the reaction is carried out inthe presence of an inert gas; the mixed solvent is a mixed solvent of tetrahydrofuran and acetone; the weight ratio of the tetrahydrofuran to the acetone in the mixed solvent is (2-9):1. High-toxicity and high ammonia nitrogen pyridine and dimethylformamide are replaced by using the mixed solvent of tetrahydrofuran and acetone without ammonia nitrogen, no high ammonia nitrogen wastewater is generated, and environment pollution can be reduced.

Preparation technology for dexamethasone sodium phosphate

-

Paragraph 0014, (2016/10/08)

The invention relates to a preparation technology for dexamethasone sodium phosphate. The preparation technology comprises the following steps: a ring-opening reaction is carried out, namely, dexamethasone acetate epoxide is employed as an initial raw material, HF and DMF are added, a reaction is performed for 3h, a ring-opening reaction is carried out and a dexamethasone acetate solution is prepared; recrystallization is carried out, namely, acetone or ether is added in the dexamethasone acetate solution, recrystallization is carried out, dexamethasone acetate is prepared, and rotary distillation is employed to remove the solvent after recrystallization; base catalysis hydrolysis is carried out, namely, dexamethasone acetate is added in Na2CO3 and methanol, a reaction is carried out for 10min, dexamethasone is prepared; pyrophosphoryl chlorine esterification is carried out, namely, dexamethasone is reacted with pyrophosphoryl chlorine and THF, and dexamethasone phosphate ester is prepared; a neutralization salt forming reaction is carried out, namely, the dexamethasone phosphate ester obtained from the fourth step is reacted with NaOH and methanol, and dexamethasone sodium phosphate is prepared. The steps are simple, raw materials are easily available, the reaction conditions are mild, the preparation technology is suitable for industrial production, and the cost is low.

Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid

-

, (2008/06/13)

This invention discloses an improved process for the production of corticoids from 17α-hydroxy steroids utilizing peroxymonosulfate.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 987-24-6