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98929-98-7

N,N'-Bis(9-fluorenylmethyloxycarbonyl)-L-histidine, commonly known as Fmoc-His(Fmoc)-OH, is an amino acid derivative that plays a crucial role in chemical synthesis and peptide chemistry. It is characterized by the presence of two 9-fluorenylmethyloxycarbonyl (Fmoc) protecting groups attached to the histidine molecule, which allows for selective deprotection and incorporation into peptide sequences.

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  • 2-[[4b,8a,9,9a-tetrahydro-4aH-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-[1-[4b,8a,9,9a-tetrahydro-4aH-fluoren-9-ylmethoxy(oxo)methyl]-4-imidazolyl]propanoic acid

    Cas No: 98929-98-7

  • No Data

  • 10 Milligram

  • Amadis Chemical Co., Ltd.
  • Contact Supplier
  • 98929-98-7 Structure

  • Basic information

    1. Product Name: N,N'-Bis(9-fluorenylmethyloxycarbonyl)-L-histidine
    2. Synonyms: FMOC-L-HIS(FMOC)-OH;FMOC-HIS(FMOC)-OH;FMOC-HISTIDINE(FMOC)-OH;NIM-DI-FMOC-L-HISTIDINE;N,N'-BIS(9-FLUORENYLMETHYLOXYCARBONYL)-L-HISTIDINE;N-ALPHA,N-TAU-DI-(9-FLUORENYLMETHOXYCARBONYL)-L-HISTIDINE;N-ALPHA,IM-BIS-FMOC-L-HISTIDINE;N-ALPHA,NIM-DI-FMOC-L-HISTIDINE
    3. CAS NO:98929-98-7
    4. Molecular Formula: C36H29N3O6
    5. Molecular Weight: 599.64
    6. EINECS: 202-716-0
    7. Product Categories: Amino Acids;Histidine [His, H];Fmoc-Amino Acids and Derivatives;Fmoc-Amino acid series
    8. Mol File: 98929-98-7.mol

  • Chemical Properties

    1. Melting Point: 144-155°C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.38 g/cm3
    6. Refractive Index: 1.696
    7. Storage Temp.: -15°C
    8. Solubility: N/A
    9. PKA: 12.26±0.46(Predicted)
    10. CAS DataBase Reference: N,N'-Bis(9-fluorenylmethyloxycarbonyl)-L-histidine(CAS DataBase Reference)
    11. NIST Chemistry Reference: N,N'-Bis(9-fluorenylmethyloxycarbonyl)-L-histidine(98929-98-7)
    12. EPA Substance Registry System: N,N'-Bis(9-fluorenylmethyloxycarbonyl)-L-histidine(98929-98-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: 22-24/25
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 98929-98-7(Hazardous Substances Data)

98929-98-7 Usage

Uses

Used in Pharmaceutical Industry:
N,N'-Bis(9-fluorenylmethyloxycarbonyl)-L-histidine is used as a building block for the synthesis of complex peptides and proteins. Its Fmoc protecting groups enable chemists to selectively incorporate histidine residues into peptide sequences, facilitating the development of novel therapeutic agents and drug candidates.
Used in Chemical Synthesis:
In the field of chemical synthesis, N,N'-Bis(9-fluorenylmethyloxycarbonyl)-L-histidine is employed as a versatile intermediate for the preparation of various histidine-containing compounds. Its Fmoc protecting groups allow for controlled synthesis and modification of complex organic molecules, contributing to the advancement of chemical research and development.
Used in Peptide Chemistry:
N,N'-Bis(9-fluorenylmethyloxycarbonyl)-L-histidine is utilized as a key component in solid-phase peptide synthesis (SPPS). The Fmoc strategy allows for the stepwise assembly of peptide chains, with the histidine derivative providing a stable and easily removable protecting group. This approach streamlines the synthesis process and enhances the yield and purity of the final peptide product.

Check Digit Verification of cas no

The CAS Registry Mumber 98929-98-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,9,2 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 98929-98:
(7*9)+(6*8)+(5*9)+(4*2)+(3*9)+(2*9)+(1*8)=217
217 % 10 = 7
So 98929-98-7 is a valid CAS Registry Number.
InChI:InChI=1/C36H29N3O6/c40-34(41)33(38-35(42)44-19-31-27-13-5-1-9-23(27)24-10-2-6-14-28(24)31)17-22-18-37-21-39(22)36(43)45-20-32-29-15-7-3-11-25(29)26-12-4-8-16-30(26)32/h1-16,18,21,31-33H,17,19-20H2,(H,38,42)(H,40,41)/t33-/m0/s1

98929-98-7 Well-known Company Product Price

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  • Alfa Aesar

  • (H62932)  N,1-Di-Fmoc-L-histidine, 95%   

  • 98929-98-7

  • 250mg

  • 226.0CNY

  • Detail

  • Alfa Aesar

  • (H62932)  N,1-Di-Fmoc-L-histidine, 95%   

  • 98929-98-7

  • 1g

  • 848.0CNY

  • Detail

  • Alfa Aesar

  • (H62932)  N,1-Di-Fmoc-L-histidine, 95%   

  • 98929-98-7

  • 5g

  • 3385.0CNY

  • Detail

98929-98-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N'-Bis(9-Fluorenylmethyloxycarbonyl)-L-Histidine

1.2 Other means of identification

Product number -
Other names (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[1-(9H-fluoren-9-ylmethoxycarbonyl)imidazol-4-yl]propanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98929-98-7 SDS

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