996-19-0

Basic information

• Product Name: AMINOGUANIDINE HEMISULFATE
• Synonyms: Di(carbazamidin)sulfat;Amidinohydrazine hemisulfate;Aminoguanidine hemisulfate,99%;Aminoguanidine Sulfate Hydrate;AMinoguanidine Sulfate Bis(aminoguanidinium) sulfate;Aminoguanidine sulfate monohydrate;Bis(1-aminoguanidinium) sulfate for synthesis
• CAS NO: 996-19-0
• Molecular Formula: 2CH₇N₄*O₄S
• Molecular Weight: 246.25
• EINECS: 213-628-7
• Mol File: 996-19-0.mol

Chemical Properties

• Melting Point: 200 °C
• Boiling Point: 261.4 °C at 760 mmHg
• Flash Point: 111.9 °C
• Appearance: White or colorless crystal
• Density: 1.36 g/cm3 (20℃)
• Storage Temp.: Store below +30°C.
• Solubility: 170g/l
• Water Solubility: almost transparency
• CAS DataBase Reference: AMINOGUANIDINE HEMISULFATE(CAS DataBase Reference)
• NIST Chemistry Reference: AMINOGUANIDINE HEMISULFATE(996-19-0)
• EPA Substance Registry System: AMINOGUANIDINE HEMISULFATE(996-19-0)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 2
• Hazardous Substances Data: 996-19-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
Aminoguanidine hemisulfate is used as a research compound for studying the effects of nitric oxide on ovulation, ovarian steroidogenesis, and prostaglandin production. Its inhibitory properties allow researchers to gain insights into the role of nitric oxide in these processes and potentially develop new therapeutic approaches.
Used in Drug Development:
Aminoguanidine hemisulfate is also used in the development of drugs targeting nitric oxide synthetase. By inhibiting the enzyme, it may help in the treatment of conditions where nitric oxide production is dysregulated, such as certain inflammatory and cardiovascular diseases.

Biochem/physiol Actions

Inhibits both constitutive and inducible nitric oxide synthetase

InChI:InChI=1/CH6N4.H2O4S/c2-1(3)5-4;1-5(2,3)4/h4H2,(H4,2,3,5);(H2,1,2,3,4)

Upstream product

• 16139-18-7 hydrazinecarboximidamide hydrochloride 
• 2582-30-1 aminoguanidine bicarbonate 

Downstream Products

• 3916-05-0 1--3-isopropylidenamino-guanidin 
• 3916-03-8 1--3-diaethylmethylenamino-guanidin 
• 105126-60-1 2C₉H₁₂N₄S*H₂O₄S 
• 67962-44-1 2C₉H₁₂N₄O*H₂O₄S 
• 105126-74-7 2C₁₁H₁₆N₄S*H₂O₄S 
• 111159-74-1 2-<1(Z)-(2,6-dimethylphenyl)ethylidene>hydrazinecarboximidamide 
• 111159-75-2 2-[1(E)-(2,6-dimethylphenyl)ethylidene]hydrazinecarboximidamide 
• 67993-02-6 2C₉H₁₁ClN₄O*H₂O₄S 
• 105126-62-3 2C₉H₁₁ClN₄S*H₂O₄S 
• 105126-64-5 2C₉H₁₁BrN₄S*H₂O₄S 
• 96159-66-9 2C₁₀H₁₄N₄O*H₂O₄S 
• 67962-48-5 2C₉H₁₁ClN₄O*H₂O₄S 
• 67962-46-3 2C₉H₁₁ClN₄O*H₂O₄S 
• 67962-70-3 2C₁₁H₁₆N₄O*H₂O₄S 

Relevant articles and documents

Thermally stable energetic salts based on 3-nitramino-4-tetrazolefurazan

In order to develop new energetic materials with high energy and low sensitivity, a series of nitrogen-rich energetic salts based on 3-nitramino-4-tetrazolefurazan were conveniently synthesized through nitration, neutralization and metathesis reaction. All energetic salts were fully characterized by NMR (1H, 13C), IR and elemental analysis. Furthermore, ammonium salt (2) was confirmed by 15N NMR and hydroxylammonium salt (5) was confirmed by single-crystal X-ray diffraction. Salt 5 crystallized in triclinic space group P1 with four hydroxylammonium cations and two NATF anions per unit cell at a density of 1.815 g cm-3. The densities of the salts are in the range of 1.621 (6) to 1.815 g cm-3 (5). Due to the two nitrogen-rich cations in the salts, they show high positive enthalpies of formation falling between 299.2 kJ mol-1 (2) and 1040.6 kJ mol-1 (9). All the salts show good thermal stabilities with the decomposition temperatures ranging from 203 °C (4) to 284 °C (6). The impact sensitivities of the energetic salts lie between 5 J (2 and 5) and >40 J (6, 7, 8) and their friction sensitivities range from 108 N (4) to >360 N (6). Their detonation performances were calculated according to Kamlet-Jacobs equations. The detonation pressures of the synthesized energetic salts were found to be in the range of 21.1 GPa (6) to 34.7 GPa (5) and their detonation velocities are between 7117 m s-1 (6) and 8826 m s-1 (5).

Crystal structures of mono-, Di-, and triaminoguanidinium sulfate, as well as azidoformamidinium sulfate: Important precursors for syntheses of nitrogen rich ionic vompounds

Bis(1-aminoguanidinium) sulfate monohydrate (AG2SO4 H2O, 1), bis(1,3-diamino-guanidinium sulfate (DAG2SO 4, 2), bis(1,3,5-triaminoguanidinium) sulfate dihydrate (TAG 2SO4 2 Hsub