99909-39-4

Basic information

• Product Name: Boc-Phe-Pro-Gly-Arg(NO₂)-OBzl
• Synonyms: Boc-Phe-Pro-Gly-Arg(NO₂)-OBzl
• CAS NO: 99909-39-4
• Molecular Weight: 710.787
• Mol File: 99909-39-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-Phe-Pro-Gly-Arg(NO₂)-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Phe-Pro-Gly-Arg(NO₂)-OBzl(99909-39-4)
• EPA Substance Registry System: Boc-Phe-Pro-Gly-Arg(NO₂)-OBzl(99909-39-4)

Safety Data

• Hazardous Substances Data: 99909-39-4(Hazardous Substances Data)

Upstream product

• 83280-18-6 BOC-phenylalanylprolylglycine benzyl ester 
• 23420-32-8 N-tert-butoxycarbonyl-L-phenylalanyl-L-proline 
• 10123-53-2 N^G-nitroarginine benzyl ester 
• 66211-31-2 N-tert-butyloxycarbonyl-L-phenylalanyl-L-prolylglycine 

Relevant articles and documents

Bitter Taste of Synthetic C-Terminal Tetrapeptide of Bovine β-Casein, H-Pro196-Val-Leu-Gly-Pro-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val209-OH, and Its Related Peptides

The primary structure of bovine β-casein contains the partial sequence of -Pro196-Val-Leu-Gly-Pro-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val209 in the C-terminal portion.We previously reported that the synthetic C-terminal octapeptide, Arg202-Val209, is extremly bitter with its threshold value 0.004 mM, 250 times as strong as that of caffeine.To further investigate the bitter taste of the C-terminal portion of β-casein, we synthesized the C-terminal tetrapeptide, Pro196-Val209, and some its fragments.A hydrophobic hexapeptide, Pro196-Val201, was twice as bitter as caffein.The bitter taste of decapeptide, Pro200-Val209, was the same as that of Arg202-Val209.Although the tetradecapeptide, Pro196-Val209, was composed of two bitter peptides, Pro196-Val201 and Arg202-Val209, its bitter taste was weaker than that of Arg202-Val209 and its threshold value was 0.015 mM.We suggested that the increase of bitterness in peptides through the introduction of hydrophobic amino acids depended on the number of hydrophobic amino acids added.In addition, the synthetic retro analog of Arg202-Val209 (H-Val-Ile-Ile-Pro-Phe-Pro-Gly-Arg-OH) was not as bitter as Arg202-Val209.This indicated that the sequence of Arg202-Val209 is important for extreme bitterness.