Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Carbazochrome

Related Products

Hot Products

Name

Carbazochrome

EINECS 200-717-0
CAS No. 69-81-8 Density 1.63 g/cm3
PSA 108.02000 LogP -0.26090
Solubility N/A Melting Point 203° (dec)
Formula C10H12N4O3 Boiling Point N/A
Molecular Weight 236.23 Flash Point N/A
Transport Information N/A Appearance nacarat crystalline powder
Safety 24/25 Risk Codes N/A
Molecular Structure Molecular Structure of 69-81-8 (Carbazochrome) Hazard Symbols N/A
Synonyms

Cromadrenal;Cromosil;NSC 73742;Sangostasin;Sangostazin;5,6-Indolinedione,3-hydroxy-1-methyl-, 5-semicarbazone (7CI,8CI);Adrenochrome semicarbazone(6CI);3-Hydroxy-1-methyl-5,6-indolindione 5-semicarbazone;Adchnon;Adedolon;Adrenochrome monosemicarbazone;Adrenostazin;Adrenoxyl;Adrezon;Adrokson;Adroxon;Cartabes;

Article Data 3

Carbazochrome Synthetic route

563-41-7

semicarbazide hydrochloride

DL-adrenochrome

DL-adrenochrome

69-81-8

(+/-)-3-hydroxy-1-methyl-indoline-5,6-dione-5-semicarbazone

Conditions
ConditionsYield
With water; sodium acetate

Carbazochrome Specification

The Carbazochrome, with the cas registry number 69-81-8, has the IUPAC name of [(Z)-(3-hydroxy-1-methyl-6-oxo-2,3-dihydroindol-5-ylidene)amino]urea. This is a kind of nacarat crystalline powder and is slightly soluble in water and ethanol while insoluble in ethyl ether and chloroform. Besides, this chemical could be obtained from oxidation, cyclization, and condensation of isoprenalinehydrochloride.

The physical properties of this chemical are as follows: (1)ACD/LogP: -1.53; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.54; (4)ACD/LogD (pH 7.4): -1.53; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 3.47; (8)ACD/KOC (pH 7.4): 3.49; (9)#H bond acceptors: 7; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 65.45; (13)Index of Refraction: 1.732; (14)Molar Refractivity: 57.88 cm3; (15)Molar Volume: 144.5 cm3; (16)Polarizability: 22.94 ×10-24 cm3; (17)Surface Tension: 71.9 dyne/cm; (18)Density: 1.63 g/cm3; (19)Exact Mass: 236.09094; (20)MonoIsotopic Mass: 236.09094; (21)Topological Polar Surface Area: 108; (22)Heavy Atom Count: 17; (23)Complexity: 478.

As to its usage, it is usually applied in pharmaceutics. It could used as the hemostatics which could cure the diseases as hereditaryhemorrhagictelangiectasia and prevent the bleeding in lung, kidney, intestine, brain and uterus.

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: CN1CC(C2=CC(=NNC(=O)N)C(=O)C=C21)O
(2)Isomeric SMILES: CN1CC(C2=C/C(=N/NC(=O)N)/C(=O)C=C21)O
(3)InChI: InChI=1S/C10H12N4O3/c1-14-4-9(16)5-2-6(12-13-10(11)17)8(15)3-7(5)14/h2-3,9,16H,4H2,1H3,(H3,11,13,17)/b12-6-
(4)InChIKey: XSXCZNVKFKNLPR-SDQBBNPISA-N 

Below are the toxicity information of this chemical:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2413mg/kg (2413mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1821, 1978.
mouse LD50 oral > 35832mg/kg (35832mg/kg)   German Offenlegungsschrift Patent Document. Vol. #2808572,
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1821, 1978.
rat LD50 intraperitoneal 1276mg/kg (1276mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1821, 1978.
rat LD50 oral > 17280mg/kg (17280mg/kg)   German Offenlegungsschrift Patent Document. Vol. #2808572,
rat LD50 subcutaneous > 12500mg/kg (12500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1821, 1978.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 69-81-8