- Production Method of Flavodilol maleate
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Flavodilol maleate (CAS NO.: ), with other name of (±)-7-(2-Hydroxy-3-(propylamino)propoxy]flavone maleate (1:1) (salt), could be produced through many synthetic methods.
Following is one of the reaction routes:
The condensation of epichlorohydrin (I) with 7-hydroxyflavone (II) by means of NaOH in ethanol - water gives 7-(2,3-epoxypropoxy)fIavone (III), which is then treated with propylamine (IV) in methanol, and neutralized with maleic acid.
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