1. Introduction of Ciclopirox
Ciclopirox is one kind of white or light-yellow powder. It is soluble in methanol, ethanol or chloroform, slightly soluble in DMF or water, slightly soluble in ethyl ether. The IUPAC Name of it is 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2-one. It belongs to Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles. In addition, the Classification Code of it is Anti-Infective Agents; Antifungal; Antifungal Agents.

2. Properties of Ciclopirox
Physical properties about Ciclopirox are:
(1)Melting Point: 144 °C; (2)Density: 1.193 g/cm³; (3)Boiling Point: 350 °C at 760 mmHg; (4)Flash Point: 165.5 °C; (5)Molar Volume: 173.6 cm³; (6)Polarizability: 22.98×10^-24 cm³; (7)Surface Tension: 51.7 dyne/cm; (8)Enthalpy of Vaporization: 68.85 kJ/mol; (9)Vapour Pressure: 2.71E-06 mmHg at 25 °C; (10)log P (octanol-water): 2.730 (none); (11)XLogP3-AA: 2; (12)H-Bond Donor: 1; (13)H-Bond Acceptor: 2; (14)Rotatable Bond Count: 1; (15)Exact Mass: 207.125929; (16)MonoIsotopic Mass: 207.125929; (17)Topological Polar Surface Area: 40.5; (18)Heavy Atom Count: 15; (19)Complexity: 325.

3. Structure Descriptors of Ciclopirox
(1)Canonical SMILES: CC1=CC(=O)N(C(=C1)C2CCCCC2)O
(2)InChI: InChI=1S/C12H17NO2/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10/h7-8,10,15H,2-6H2,1H3
(3)InChIKey: SCKYRAXSEDYPSA-UHFFFAOYSA-N
(4)Smiles: c1(cc(cc(n1O)C1CCCCC1)C)=O

4. Physical Properties of Ciclopirox

Physical Property	Value	Units	Temp (deg C)	Source
Melting Point	144	deg C		EXP
log P (octanol-water)	2.730	(none)		EST
Atmospheric OH Rate Constant	7.97E-11	cm3/molecule-sec	25	EST

5. Uses of Ciclopirox
Ciclopirox olamine (also called Batrafen, Loprox, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against Tinea versicolor. It can be used as broad spectrum antimycotic agent with some antibacterial activity.

6. Production of Ciclopirox
Cyclohexane carboxylic acid and thionyl chloride reacted to get cyclohexane chloride. It reacts with 3-methyl-2-butenoate (I) in dichloromethane solvent under the action of the three aluminum chloride, stirring 4h, after post-processing, the vacuum collection of 140-145 °C (0.4kPa), may get 5-oxo-3-methyl-5- Ring Hexyl-3-ene acid methyl ester (ciclopirox Division, II), yield 75%. Again, with hydroxylamine hydrochloride, sodium acetate, methanol and water at room temperature, stirring 20h, adding 50% sodium hydroxide and then stirred 1h. Extracted with benzene after cooling, the water phase acidified to Ph = 6. Then ethanol precipitation of crystals recrystallized, you can get Ciclopirox (CAS NO.29342-05-0) , melting point 140 ~ 142 °C, the yield of 48.3%. Finally with the hydroxyl amine salt in dichloromethane, get almost quantitative ciclopirox olamine, melting point 97 ~ 99 °C.

Or MESITYL OXIDE can be used to manufacture Ciclopirox which is showed as follows: