- Dantrolene
- Dantrolene sodium
- Dantrolene sodium salt
- 14663-53-72-(4-oxoquinazolin-3-yl)acetate
- 14664-55-24-Thiazolidinone,5-[4-(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)-1-phenyl-2-buten-1-ylidene]-3-ethyl-2-thioxo-
- 146645-63-8N-in-Boc-L-tryptophan
- 1466-48-4Heptanedinitrile,4-(2-cyanoethyl)-4-nitro-
- 146651-75-4Carbamic acid,N-(2-aminophenyl)-, 1,1-dimethylethyl ester
- 146659-78-1b-D-Allofuranuronic acid,5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1-(5-carboxy-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-1,5-dideoxy-,zinc salt (1:1) (9CI)
- 146664-08-6Phenylalanine,N-acetyl-4-cyano-
- 146664-09-7D-Phenylalanine,N-acetyl-4-cyano-
- 146665-77-2Platinum,[(4R,5R)-2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-kN4,kN5][propanedioato(2-)-kO1,kO3]-,(SP-4-2)- (9CI)
- 146667-84-71-Piperidinecarboxylicacid, 3-(2-hydroxyethyl)-, 1,1-dimethylethyl ester
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
Dantrolene sodium salt |
EINECS | 238-706-8 |
| CAS No. | 14663-23-1 | Density | N/A |
| PSA | 127.05000 | LogP | 1.71410 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C14H9N4O5Na | Boiling Point | 85°C 4mm |
| Molecular Weight | 336.239 | Flash Point | 283.1oC |
| Transport Information | N/A | Appearance | COA |
| Safety | 22-24/25 | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
2,4-Imidazolidinedione,1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt (9CI);Hydantoin, 1-[[5-(p-nitrophenyl)furfurylidene]amino]-, sodium salt (8CI);Dantrium;Dantrolene sodium;F 440;Sodium dantrolene; |
Article Data | 1 |
Dantrolene sodium salt Synthetic route
- 7261-97-4
dantrolene
- 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
| Conditions | Yield |
|---|---|
| With sodium methylate In methanol at 20℃; for 3h; | 100% |
- 7147-77-5
5-(4-nitrophenyl)-2-furaldehyde
- 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 81 percent / H2O; dimethylformamide 2: 100 percent / CH3ONa / methanol / 3 h / 20 °C View Scheme |
- 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
- 7261-97-4
dantrolene
| Conditions | Yield |
|---|---|
| With acetic acid In N,N-dimethyl-formamide at 20℃; | 98% |
- 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
- 89151-46-2
tert-butyl 4-(2-iodoethyl)piperidine-1-carboxylate
| Conditions | Yield |
|---|---|
| In N,N-dimethyl-formamide at 20℃; | 96.4% |
- 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
- 145508-94-7
tert-butyl 4-(iodomethyl)piperidine-1-carboxylate
| Conditions | Yield |
|---|---|
| In N,N-dimethyl-formamide at 20℃; | 51.6% |
- 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
- 229625-50-7
di-tert-butyl chloromethyl phosphate
| Conditions | Yield |
|---|---|
| With sodium iodide In N,N-dimethyl-formamide at 0 - 20℃; for 64h; Temperature; | 45% |
- 34573-36-9
N-[(1,1-dimethylethoxy)carbonyl]glycine chloromethyl ester
- 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
| Conditions | Yield |
|---|---|
| In N,N-dimethyl-formamide at 20℃; for 110h; | 27% |
- 432037-43-9
tert-butyl chloromethyl butanedioate
- 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
| Conditions | Yield |
|---|---|
| In N,N-dimethyl-formamide at 20℃; for 20h; | 20% |
- 3221-20-3
1-benzyl-4-(2-hydroxyethyl)piperazine
- 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
| Conditions | Yield |
|---|---|
| Stage #1: 1-benzyl-4-(2-hydroxyethyl)piperazine With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 0.333333h; Mitsunobu Displacement; Stage #2: 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt In tetrahydrofuran at 60℃; | 5.7% |
- 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
- 540-51-2
2-bromoethanol
| Conditions | Yield |
|---|---|
| Stage #1: 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt With potassium carbonate In tetrahydrofuran; water for 0.5h; Stage #2: 2-bromoethanol In tetrahydrofuran; water at 20℃; for 24h; |
Dantrolene sodium salt Chemical Properties
Molecular Structure of Dantrolene sodium salt (CAS NO.14663-23-1):
IUPAC Name: Sodium 3-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-5-oxo-4H-imidazol-2-olate
Molecular Formula: C14H9N4O5Na
Molecular Weight: 336.26g/mol
EINECS: 238-706-8
Boiling Point: 544.5 °C at 760 mmHg
Flash Point: 283.1 °C
Properties: solid
Freely Rotating Bonds: 4
Polar Surface Area: 124.22 Å2
Polarizability: 10-24 cm3
Enthalpy of Vaporization: 86.63 kJ/mol
Vapour Pressure: 1.09E-12 mmHg at 25°C
InChI
InChI=1/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;
Smiles
N1(CC([NH-]C1=O)=O)\N=C\c1oc(cc1)c1ccc(cc1)[N+](=O)[O-].[Na+]
The chemical synonyms of Dantrolene sodium salt (CAS NO.14663-23-1) are Sodium dantrolene ; Dantrium ; Dantrolene na ; Dantrolene sodium salt ; 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt ; 1-[[[5-(4-Nitrophenyl)-2-furanyl]-methylene]imino]2,4-imidazolidinedione sodium salt ; 1-[(5-[p-Nitrophenyl]furfurylidene)-amino]hydantoin sodium salt ; 1-((5-(p-Nitrophenyl)furfurylidene)amino)hydantoinsodium .
Product categories: Pharmacetical ; API's ; InsP3/Ryanodine receptor .The molecular structure of Dantrium
Dantrolene sodium salt Toxicity Data With Reference
| 1. | orl-hmn TDLo:320 mg/kg:BAH,GIT | JAMAAP JAMA, Journal of the American Medical Association. 231 (1975),662. | ||
| 2. | orl-wmn LDLo:600 mg/kg:GIT,SYS | NYSJAM New York State Journal of Medicine. 77 (1977),1759. | ||
| 3. | orl-rat LD50:7431 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 12 (1981),668. | ||
| 4. | ipr-rat LD50:413 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 12 (1981),668. | ||
| 5. | orl-mus LD50:1188 mg/kg | JPMSAE Journal of Pharmaceutical Sciences. 69 (1980),327. | ||
| 6. | ipr-mus LD50:534 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 12 (1981),668. |
Dantrolene sodium salt Safety Profile
Moderately toxic by intraperitoneal and ingestion routes. Human systemic effects by ingestion: anorexia (human), hepatitis, nausea or vomiting, somnolence. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Na2O.
Safety Statements: 22-24/25
22: Do not breathe dust
24/25: Avoid contact with skin and eyes
WGK Germany: 2
RTECS: MU3875000
Dantrolene sodium salt Specification
In order to capture and identify key molecules that regulate the release of Ca(2+) from the sarcoplasmic reticulum (SR) of skeletal muscle, we designed specific photoaffinity probes based on the structural modification of dantrolene. Thus, GIF-0082 and GIF-0276 possessing azido- and trifluoromethyldiazirinyl-benzyl groups, respectively, at the hydantoin moiety were found to have a highly selective inhibitory effect on physiological Ca(2+) release without affecting Ca(2+)-induced Ca(2+) release (CICR). Successful realization of the sharp discrimination between PCR and CICR has led to the creation of [(125)I]GIF-0082 and [(125)I]GIF-0276, which were synthesized by substituting a stannyl group with (125)I in the corresponding phenylstannane precursors. It is a muscle relaxation drug for treatment of diseases associated with spastic paralysis.
What can I do for you?
Get Best Price
