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Dexamethasone 21-phosphate disodium salt

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Dexamethasone 21-phosphate disodium salt

EINECS 219-243-0
CAS No. 2392-39-4 Density 1.32g/cm3
PSA 156.83000 LogP 2.88910
Solubility water: 50 mg/mL, clear, faintly yellow Melting Point 233-235 °C
Formula C22H30FO8P.2Na Boiling Point 669.6 °C at 760 mmHg
Molecular Weight 516.45 Flash Point 358.7 °C
Transport Information Appearance White to off white powder
Safety 36/37/39 Risk Codes 22-40-63
Molecular Structure Molecular Structure of 2392-39-4 (Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, sodium salt (1:2), (11b,16a)-) Hazard Symbols R22:; R40:; R63:;

Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11b,16a)- (9CI);Dexagro;Dexamethasone 21-(disodium phosphate);Dexamethasone phosphate sodium salt;Dexamethazone sodium phosphate;Dezone;Disodium dexamethasone 21-phosphate;


Dexamethasone 21-phosphate disodium salt Consensus Reports

Reported in EPA TSCA Inventory.

Dexamethasone 21-phosphate disodium salt Specification

The Decadron phosphate, with the cas register number 2392-39-4, has the systematic name of disodium (11beta,16alpha)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl phosphate. This is a kind of white to off-white powder. Besides, the product categories are various, including immunomodulators and antibioticslipids; steroids (c21) and derivatives; immune cell signaling and blood; immune system regulation; sterols. When store it, you should keep in at 2-8°C.

The characteristics of this chemical are as follows: (1)ACD/LogP: 0.65; (2)ACD/LogD (pH 5.5): -2.77; (3)ACD/LogD (pH 7.4): -3.69; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 8; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 6; (11)Polar Surface Area: 129.17; (12)Flash Point: 358.7 °C; (13)Enthalpy of Vaporization: 112.61 kJ/mol; (14)Boiling Point: 669.6 °C at 760 mmHg; (15)Vapour Pressure: 8.62E-21 mmHg at 25°C.

As to its usage, it is widely applied in the pharmaceutics. It is usually used as the adrenal cortex hormonic drug, which has the function of being anti-flammatory, antitoxic, and antiallergic.

While dealing with this chemical, you should be very cautious. For being a kind of harmful chemical, it may cause damage to health, and if swallowed, it will be very dangerous. Besides, it has possible risk of harm to the unborn child, and even has limited evidence of a carcinogenic effect. Therefore, you should take the following instruction. Wear suitable protective clothing, gloves and eye/face protection. If you need more safety information, you could refer to WGK Germany  3. 
In addition, you could obtain the molecular structure by converting the following datas:

Below are the toxicity information of this chemical:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 1mg/kg (1mg/kg) GASTROINTESTINAL: PERITONITIS American Journal of Emergency Medicine. Vol. 10, Pg. 268, 1992.
infant TDLo intravenous 1500ug/kg/3D- (1.5mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS Lancet. Vol. 1, Pg. 632, 1987.
man TDLo intravenous 357ug/kg (0.357mg/kg) GASTROINTESTINAL: PERITONITIS American Journal of Emergency Medicine. Vol. 10, Pg. 268, 1992.
mouse LD50 intraperitoneal 550mg/kg (550mg/kg)   Archives of Toxicology, Supplement. Vol. 7, Pg. 90, 1984.
mouse LD50 intravenous 932mg/kg (932mg/kg)   Drugs in Japan Vol. -, Pg. 785, 1995.
mouse LD50 oral 1800mg/kg (1800mg/kg)   Archives of Toxicology, Supplement. Vol. 7, Pg. 90, 1984.
women TDLo intravenous 320mg/kg (320mg/kg) GASTROINTESTINAL: OTHER CHANGES Lancet. Vol. 1, Pg. 1035, 1986.

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