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| Name |
Dichloromethylenediphosphonic acid disodium salt |
EINECS | 245-078-9 |
| CAS No. | 22560-50-5 | Density | 2.306g/cm3 |
| PSA | 140.34000 | LogP | 1.30710 |
| Solubility | N/A | Melting Point |
>330 °C |
| Formula | CH2Cl2Na2O6P2 | Boiling Point | 474.7oC at 760mmHg |
| Molecular Weight | 332.82 | Flash Point | 240.9oC |
| Transport Information | N/A | Appearance | White solid |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Phosphonicacid, (dichloromethylene)bis-, disodium salt (9CI);Phosphonic acid, (dichloromethylene)di-,disodium salt (8CI);(Dichloromethylene)diphosphonate disodium;BM 06011;Bonefos;Clasteon;Clodronate disodium salt;Clodronate sodium;Clodronic aciddisodium salt;DClMDP;Dichloromethylenebisphosphonic acid disodium salt;Dichloromethylenediphosphonic acid disodium salt;Difoafonal;Diphosfonal;Disodium (dichloromethane)diphosphonate;Disodium(dichloromethylene)bisphosphonate;Disodium (dichloromethylene)diphosphonate;Disodium clodronate;Lodronate;Loron;Mebonat;Ossiten;Ostac;Sodium(dichloromethylene)diphosphonate;Sodium clodronate; |
Dichloromethylenediphosphonic acid disodium salt Chemical Properties
IUPAC Name: disodium [dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate (22560-50-5)
Synonyms: Clodronic acid disodium salt
Molecular Structure : 
Molecular Formula : CH2Cl2Na2O6P2
Molecular Weight : 288.86
CAS: 22560-50-5
EINECS: 245-078-9
Product Categories: All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents
Mol File: 22560-50-5.mol
Melting point: >330°C
Dichloromethylenediphosphonic acid disodium salt Uses
Sodium clodronate (22560-50-5) is used for Hypercalcaemia (too much calcium in the blood) ,some types of bone pain .
Dichloromethylenediphosphonic acid disodium salt Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 780mg/kg (780mg/kg) | British UK Patent Application. Vol. #2096889, | |
| mouse | LD50 | intravenous | 75mg/kg (75mg/kg) | British UK Patent Application. Vol. #2096889, | |
| mouse | LD50 | oral | > 2gm/kg (2000mg/kg) | British UK Patent Application. Vol. #2096889, |
Dichloromethylenediphosphonic acid disodium salt Safety Profile
WGK Germany : 3
RTECS: SZ7640700
Dichloromethylenediphosphonic acid disodium salt Specification
1.Sodium clodronate (22560-50-5) works by binding to bone and reducing the rate at which bone is broken down.
2.When bone is broken down, calcium is lost from the bone and seeps into the blood. In cancer, there is excessive breakdown of bone which leads to high levels of calcium in the blood. As sodium clodronate prevents bone from being broken down as quickly, it reduces these high levels of calcium in the blood that are a result of cancer.
3.Store Sodium clodronate (22560-50-5) in a cool, dry place, away from direct heat and light
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