A chemical reaction in which two substances unite to form a third; the reacting substances may be elements or compounds, but the product is always a compound, e.g., Cu + Cl2 → CuCl2 and 2NH3 + H2SO4 → (NH4)2SO4. Polymerization is a special case of combination, where complex organic molecules of the same kind unite to form chains or clusters of high molecular weight. See Polymerization.