A strand or fragment of genetic material existing outside the chromosomes in certain types of bacteria. R-type plasmids, which are present in E. coli, impart resistance to antibiotics in organisms that are exposed to them. The plasmids can be transferred from animals to humans, as well as to other, harmful bacteria that also become resistant to antibiotics. Feeding of traces of antibiotics to animals is believed to promote the growth of E. coli and, thus, to produce strains of pathogenic bacteria that are not amenable to antibiotic treatment. For this reason FDA has recommended elimination of certain antibiotics from animal feeds, e.g., penicillin, oxytetracycline, and chlortetracycline. Synthetic plasmids have been used successfully in recombinant DNA research.