Creation of a substance that either duplicates a natural product or is a unique material not found in nature, by means of one or more chemical reactions, or (for elements) by a nuclear change. High temperature and pressures as well as a catalyst are usually required. Though syntheses are more readily achieved with organic compounds because of the great versatility of the carbon atom, extremely important syntheses of inorganic compounds were made in the early years of chemistry. A list of noteworthy syntheses with approximate dates would include the following:
Inorganic
Organic
sulfuric acid
urea (Wohler)
1828
(chamber)
1746
mauveine (Perkin)
1857
(contact)
1890
Celluloid (Hyatt)
1869
soda ash (LeBlanc)
1800
ethylbenzene
(Solvay)
1861
(Friedel Crafts)
1877
ammonia
rayon
(Haber-Bosch)
1912
(Chardonnet)
1884
plutonium
1940
phenolic resins
(Baekeland)
1910
neoarsphenamine
(Ehrlich)
1910
aldehydes, alcohols
(Oxo synthesis)
1920
methanol
1927
neoprene
(Nieuwland)
1930
nylon (Carothers)
1935
SBR rubber
1940
polyisoprene
1950
The tremendous proliferation of synthetic materials in recent years, especially in the high-polymer field, was made possible by the increasingly sophisticated use of catalysts, particularly the Ziegler and Natta stereospecific type.Synthesis of elements has also occurred; since 1940 all the transuranic elements from 93 to 106, as well as a vast array of radioisotopes of natural elements, have been created by nuclear bombardment of various types.See Resin, Synthetic; Semisynthetic.