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Name |
Doxifluridine |
EINECS | 221-440-1 |
CAS No. | 3094-09-5 | Density | 1.63 g/cm3 |
PSA | 104.55000 | LogP | -1.68520 |
Solubility | N/A | Melting Point |
188-192 °C(lit.) |
Formula | C9H11FN2O5 | Boiling Point | N/A |
Molecular Weight | 246.195 | Flash Point | N/A |
Transport Information | N/A | Appearance | White solid |
Safety | 26-36 | Risk Codes | 36/37/38 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
5-Fluoro-5'-deoxyuridine;5-Fluorodesoxyuridine;5'-DFUR;5'-Deoxy-5-fluorouridine;5'-dFUrd;Flutron;Furtulon;Ro 21-9738;Uridine,5'-deoxy-5-fluoro-;Doxyflruidine; |
Article Data | 17 |
IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione
Empirical Formula: C9H11FN2O5
Molecular Weight: 246.1924
EINECS: 221-440-1
Product Categories: Heterocycles; Pyridines, Pyrimidines, Purines and Pteredines; Pyrazines, Pyrimidines & Pyridazines; API intermediates; Biochemistry; Chemical Reagents for Pharmacology Research; Nucleosides and their analogs; Nucleosides, Nucleotides & Related Reagents; Bases & Related Reagents; Nucleotides; Intermediates & Fine Chemicals; Pharmaceuticals; Pyrazines, Pyrimidines & Pyridazines
Index of Refraction: 1.605
Molar Refractivity: 51.91 cm3
Molar Volume: 150.6 cm3
Surface Tension: 69.8 dyne/cm
Density: 1.63 g/cm3
Appearance: White Solid
Melting Point: 188-192 °C(lit.)
Classification Code of Doxifluridine (CAS NO.3094-09-5): Antimetabolites; Antimetabolites, Antineoplastic; Antineoplastic agents; Appetite stimulants; Central Nervous System Agents; Central Nervous System Stimulants; Drug / Therapeutic Agent; Immunologic Factors; Immunosuppressive agents; Mutation data; Noxae; Reproductive Effect
Doxifluridine (CAS NO.3094-09-5) is a prodrug of 5-Flurouridine and a fluorinated pyrimidine nucleoside with cytostatic activity. It is used as an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine .
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | > 1gm/kg (1000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl, | |
mouse | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl, |
mouse | LDLo | oral | 5gm/kg (5000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl, |
rat | LD50 | intravenous | > 1gm/kg (1000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl, | |
rat | LD50 | oral | 3390mg/kg (3390mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl, |
rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl, |
Hazard Codes:Xi
WGK Germany :2
RTECS:YU7526000
Hazard Note:Irritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
HazardClass: IRRITANT, IRRITANT-HARMFUL
Doxifluridine (CAS NO.3094-09-5), its Synonyms are 1-(beta-D-5-Desoxyribofuranoxyl)-5-fluoruracil ; 5'-Deoxy-5-fluorouridine ; 5'-Dfur ; 5'-Doxifluridine ; Doxifluridina ; Flutron ; Furtulon ; Doxifluridinum ; Uridine, 5'-deoxy-5-fluoro- ; Uridine-5'-deoxy-5-fluoro- .