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Cas Database |
| Name |
Efavirenz |
EINECS | 620-492-6 |
| CAS No. | 154598-52-4 | Density | 1.53 g/cm3 |
| PSA | 38.33000 | LogP | 4.21110 |
| Solubility | 8mg/L(temperature not stated) | Melting Point |
139-141 °C |
| Formula | C14H9ClF3NO2 | Boiling Point | 340.6 °C at 760 mmHg |
| Molecular Weight | 315.679 | Flash Point | 159.8 °C |
| Transport Information | N/A | Appearance | white to slightly pink crystalline powder |
| Safety | 61 | Risk Codes | 50 |
| Molecular Structure |
|
Hazard Symbols | N |
| Synonyms |
2H-3,1-Benzoxazin-2-one,6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)- (9CI);(-)-Efavirenz;DMP 266;Sustiva;(4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one;Stocrin;(S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one; |
Article Data | 40 |
Efavirenz Chemical Properties
Molecular structure of Efavirenz (CAS NO.154598-52-4) is:
Product Name: Efavirenz
CAS Registry Number: 154598-52-4
IUPAC Name: (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
Molecular Weight: 315.67497 [g/mol]
Molecular Formula: C14H9ClF3NO2
XLogP3-AA: 4
H-Bond Donor: 1
H-Bond Acceptor: 5
Melting Point: 139-141°C
Surface Tension: 51.3 dyne/cm
Density: 1.53 g/cm3
Flash Point: 159.8 °C
Enthalpy of Vaporization: 58.41 kJ/mol
Boiling Point: 340.6 °C at 760 mmHg
Vapour Pressure: 8.53E-05 mmHg at 25°C
Product Categories: Active Pharmaceutical Ingredients;chiral;Anti-viral Compounds;Anti-virals;Inhibitors;Intermediates & Fine Chemicals;Non-nucleoside Reverse Transcriptase;Pharmaceuticals
Efavirenz History
Efavirenz (CAS NO.154598-52-4) was approved by the FDA on September 21, 1998, making it the 14th approved antiretroviral drug.
Efavirenz Uses
Efavirenz (CAS NO.154598-52-4) is used to treat HIV infection. It is never used alone and is always given in combination with other drugs. It is a non-nucleoside reverse transcriptase inhibitor of HIV-1 (human immunodeficiency virus-1). Reverse transcriptase is an enzyme that can transcribe RNA into DNA to copy genetic information from RNA to DNA, therefore also called RNA-directed DNA polymerase.
Efavirenz Specification
Efavirenz , its cas register number is 154598-52-4. It also can be called (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one ; (S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one ; DMP 266 ; Stocrin ; Sustiva ; 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)- .It is a white to slightly pink crystalline powder.
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