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Ephedrine hydrochloride

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Name

Ephedrine hydrochloride

EINECS 200-074-6
CAS No. 50-98-6 Density N/A
PSA 32.26000 LogP 2.52080
Solubility N/A Melting Point 216-220 °C(lit.)
Formula C10H15NO.HCl Boiling Point 255 °C at 760 mmHg
Molecular Weight 201.696 Flash Point 85.6 °C
Transport Information N/A Appearance colourless crystals or white crystalline powder
Safety 22-23 Risk Codes 22
Molecular Structure Molecular Structure of 50-98-6 (Ephedrine hydrochloride) Hazard Symbols HarmfulXn
Synonyms

Benzenemethanol,a-[(1S)-1-(methylamino)ethyl]-,hydrochloride, (aR)-(9CI);Benzenemethanol, a-[1-(methylamino)ethyl]-, hydrochloride, [R-(R*,S*)]-;Ephedrine,hydrochloride, (-)- (8CI);(-)-Ephedrin hydrochloride;(-)-Ephedrinehydrochloride;(1R,2S)-(-)-2-Ephedrinium hydrochloride;(1R,2S)-(-)-Ephedrinehydrochloride;(1R,2S)-Ephedrine hydrochloride;Altusin;CPDD 0047;Ephedral;Ephedrine hydrochloride;Ephedrinium chloride;Ephedronguent;L-Ephedrinehydrochloride;L-erythro-Ephedrine hydrochloride;Sanedrine;l-Ephedrine hydrochloride;

Article Data 13

Ephedrine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Ephedrine hydrochloride Specification

The Ephedrine hydrochloride is an organic compound with the formula C10H15NO.HCl. The IUPAC name of this chemical is (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol hydrochloride. With the CAS registry number 50-98-6, it is also named as (1R,2S)-Ephedrine Hydrochloride. The product's classification codes are Bronchodilator; Drug / Therapeutic Agent; Human Data. Besides, it is a colourless crystals or white crystalline powder, which should be stored in a closed cool and dry place. It is used as a stimulant, appetite suppressant, oncentration aid, decongestant, and to treat hypotension associated with anaesthesia.

Physical properties of Ephedrine hydrochloride:
 (1)ACD/LogP: 1.05; (2)ACD/LogD (pH 5.5): -1.99; (3)ACD/LogD (pH 7.4): -0.96; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 12.47 Å2; (12)Flash Point: 85.6 °C; (13)Enthalpy of Vaporization: 52.03 kJ/mol; (14)Boiling Point: 255 °C at 760 mmHg; (15)Vapour Pressure: 0.00865 mmHg at 25°C.

Uses of Ephedrine hydrochloride:
Ephedrine hydrochloride is used to treat and prevent breathing difficulties due to asthma.It is a sympathomimetic agent, sometimes known as an adrenoreceptor agonist or bronchodilator. It is used to open up the airways by relaxing the smooth muscles in the lungs to help people with asthma breathe more easily. In an asthma attack, the lung smooth muscle contracts making it difficult to breathe properly. Ephedrine hydrochloride relaxes the lung smooth muscle, but also makes the smooth muscle of blood vessels narrow leading to side effects. In general this drug is used to treat and prevent asthma, but is less widely used than selective ß2 agonist such as salbutamol and terbutaline due to its safety profile. Benefits of being on this drug can include relief from symptoms such as chest tightness, breathlessness, wheezing and cough.

Safety information of Ephedrine hydrochloride:
When you are using Ephedrine hydrochloride please be cautious about it as the following:It is harmful if swallowed. When you are using it, do not breathe dust and do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.O[C@H](c1ccccc1)[C@@H](NC)C
(2)InChI: InChI=1/C10H15NO.ClH/c1-8(11-2)10(12)9-6-4-3-5-7-9;/h3-8,10-12H,1-2H3;1H/t8-,10-;/m0./s1
(3)InChIKey: BALXUFOVQVENIU-GNAZCLTHBA
(4)Std. InChI: InChI=1S/C10H15NO.ClH/c1-8(11-2)10(12)9-6-4-3-5-7-9;/h3-8,10-12H,1-2H3;1H/t8-,10-;/m0./s1
(5)Std. InChIKey: BALXUFOVQVENIU-GNAZCLTHSA-N

The toxicity data of Ephedrine hydrochloride is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 60mg/kg (60mg/kg) CARDIAC: OTHER CHANGES Medecine Vol. 9, Pg. 59, 1930.
dog LDLo intravenous 70mg/kg (70mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Medecine Vol. 9, Pg. 59, 1930.
dog LDLo subcutaneous 220mg/kg (220mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Medecine Vol. 9, Pg. 59, 1930.
frog LDLo parenteral 440mg/kg (440mg/kg)   Manshu Igaku Zasshi. Manchuria Medical Journal. Vol. 3, Pg. 1, 1925.
frog LDLo subcutaneous 400mg/kg (400mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Medecine Vol. 9, Pg. 59, 1930.
guinea pig LD50 intravenous 98mg/kg (98mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: EXCITEMENT
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963.
guinea pig LD50 subcutaneous 192mg/kg (192mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: EXCITEMENT
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 59, Pg. 355, 1963.
hamster LDLo intraperitoneal 350mg/kg (350mg/kg) CARDIAC: OTHER CHANGES Medecine Vol. 9, Pg. 59, 1930.
human TDLo intradermal 5700ng/kg (0.0057mg/kg) PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 295, 1942.
mouse LD50 intraperitoneal 242mg/kg (242mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 158, Pg. 135, 1967.
mouse LD50 intravenous 95mg/kg (95mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949.
mouse LD50 oral 400mg/kg (400mg/kg)   Journal of Medicinal Chemistry. Vol. 9, Pg. 966, 1966.
mouse LD50 subcutaneous 40870ug/kg (40.87mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 214, 1946.
mouse LDLo parenteral 500mg/kg (500mg/kg)   Manshu Igaku Zasshi. Manchuria Medical Journal. Vol. 3, Pg. 1, 1925.
rabbit LD50 intramuscular 175mg/kg (175mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
rabbit LD50 intravenous 65mg/kg (65mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949.
rabbit LD50 subcutaneous 165mg/kg (165mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
rat LD50 intraperitoneal 165mg/kg (165mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
rat LD50 intravenous 69mg/kg (69mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 33, Pg. 80, 1944.
rat LD50 subcutaneous 1150mg/kg (1150mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 336, 1949.