Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Estra-4,9-diene-3,17-dione

Related Products

Hot Products

Name

Estra-4,9-diene-3,17-dione

EINECS 610-717-6
CAS No. 5173-46-6 Density 1.16 g/cm3
PSA 34.14000 LogP 3.76150
Solubility N/A Melting Point 131-134oC
Formula C19H20O2 Boiling Point 466.5 °C at 760 mmHg
Molecular Weight 270.371 Flash Point 173.4 °C
Transport Information N/A Appearance white or almost white crystalline powder
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 5173-46-6 (Estra-4,9-diene-3,17-dione) Hazard Symbols N/A
Synonyms

19-Norandrosta-4,9-diene-3,17-dione;

Article Data 28

Estra-4,9-diene-3,17-dione Synthetic route

6218-29-7

17β-hydroxyestra-4,9-dien-3-one

5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
With tetrapropylammonium perruthennate for 3h;98%
With Jones reagent In acetone at 0℃; Jones Oxidation;97%
With tert.-butylhydroperoxide; 3 A molecular sieve; zircornium(IV) n-propoxide In dichloromethane for 17h;90%
2503-06-2

estra-4,9-diene-3,17-dione

5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 0.75h; Reflux;61%
With toluene-4-sulfonic acid
With phosphoric acid In dichloromethane; water

C17H24O4

A

5173-46-6

4,9-Androstadiene-3,17-dione

B

2503-06-2

estra-4,9-diene-3,17-dione

Conditions
ConditionsYield
With piperdinium acetate In toluene for 16h; Reflux;A 36.4%
B 36.6%
33383-89-0, 40013-34-1, 40013-38-5, 65166-16-7

(3aS,7aS)-4-(3,7-Dioxo-octyl)-7a-methyl-hexahydro-indene-1,5-dione

5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
With piperdinium acetate
Multi-step reaction with 2 steps
1: piperidine*AcOH
2: TsOH
View Scheme
36668-14-1

3S,6aS,3-(4-oxo-1-pentyl)-6a-methyl-1,2,3,5,6,6a-hexahydrocyclopenta[f][1]benzopyran-7(8H)-one

5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: piperidine*AcOH
View Scheme
Multi-step reaction with 3 steps
2: piperidine*AcOH
3: TsOH
View Scheme
5189-96-8

10β-hydroxy-19-norandrost-4-ene-3,17-dione

5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
With phosphoric acid; sulfuric acid In dichloromethane; isopropyl alcohol

(+)-3,3-dimethylpropylenedioxy-4,5-seco-estr-9-ene-5,17-dione

10582-53-3

(+)-4,5-seco-estr-9-ene-3,5,17-trione

865-47-4

potassium tert-butylate

5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
With sodium chloride; sodium acetate; acetic acid In hexane; water; acetone; toluene; tert-butyl alcohol

3-(tert-butyldimethylsilyloxy)-3a-methyl-6-(3-oxobutyl)-3,3a,4,5,8,9,9a,9b-octaammon-1H-cyclopentadiene[a]naphthalene-7(2Η)-one

5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
3: Jones reagent / acetone / 0 °C
View Scheme

C24H38O2Si

5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
2: Jones reagent / acetone / 0 °C
View Scheme
17553-86-5

(S)-Halos-Parish ketone

5173-46-6

4,9-Androstadiene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: sodium tetrahydroborate / ethanol / 4 h / -15 °C
2.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 0 - 20 °C
3.1: sodium hydride / mineral oil; dimethyl sulfoxide / 3 h / 50 °C
3.2: 2 h
4.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / -90 - -70 °C
5.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
6.1: sodium methylate / methanol / 1.5 h / Reflux
7.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
7.2: 17 h / 20 °C
8.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
9.1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
11.1: Jones reagent / acetone / 0 °C
View Scheme
Multi-step reaction with 11 steps
1.1: sodium tetrahydroborate / ethanol / 4 h / -15 °C
2.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 0 - 20 °C
3.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
3.2: 17 h / 20 °C
4.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / -90 - -70 °C
5.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
6.1: sodium methylate / methanol / 1.5 h / Reflux
7.1: sodium hydride / mineral oil; dimethyl sulfoxide / 4 h / 20 °C
7.2: 17 h / 20 °C
8.1: pyridinium p-toluenesulfonate / acetone; water / 5 h / 60 °C
9.1: potassium tert-butylate / toluene; tert-butyl alcohol / 5 h / 20 °C
10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
11.1: Jones reagent / acetone / 0 °C
View Scheme

Estra-4,9-diene-3,17-dione Chemical Properties

Molecule structure of Estra-4,9-diene-3,17-dione (CAS NO.5173-46-6):

Molecular Formula: C19H20O2
Molecular Weight: 280.36 g/mol
Density: 1.16 g/cm3 
Boiling Point: 466.5 °C at 760 mmHg
Flash Point: 173.4 °C
Index of Refraction: 1.575
Molar Refractivity: 76.55 cm3
Molar Volume: 231.6 cm3
Surface Tension: 44.8 dyne/cm 
Enthalpy of Vaporization: 72.83 kJ/mol 
Vapour Pressure: 7.03E-09 mmHg at 25 °C 
InChI: InChI=1/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10,15-16H,2-9H2,1H3 
InChIKey: BHTWZQKERRCPRZ-UHFFFAOYAS 
Product Categories: Pharmaceutical Intermediates;Amino Acids; Intermediates & Fine Chemicals; Metabolites & Impurities; Pharmaceuticals; Steroids

Estra-4,9-diene-3,17-dione Uses

 Estra-4,9-diene-3,17-dione (CAS NO.5173-46-6) is a potential metabolitie of STS 557 (Dienogest). It is also a steroid with antiglucocorticoid activity. Estra-4,9-diene-3,17-dione can be used as pharmaceutical intermediates.

Estra-4,9-diene-3,17-dione Specification

 Estra-4,9-diene-3,17-dione (CAS NO.5173-46-6) is also named as 19-norandrosta-4,9-diene-3,17-dione . Estra-4,9-diene-3,17-dione (CAS NO.5173-46-6) is white or almost white crystalline powder.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 5173-46-6