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Name |
Ethyl 1-(2,4-difluorophenyl)-7-chloro-6-fluoro-4-oxopyridino[2,3-b]pyridine-3-carboxylate |
EINECS | 422-360-1 |
CAS No. | 100491-29-0 | Density | 1.523 g/cm3 |
PSA | 61.19000 | LogP | 3.63310 |
Solubility | N/A | Melting Point |
212-215 °C |
Formula | C17H10ClF3N2O3 | Boiling Point | 502.504 °C at 760 mmHg |
Molecular Weight | 382.726 | Flash Point | 257.705 °C |
Transport Information | N/A | Appearance | almost white powder |
Safety | 37/39-26 | Risk Codes | 36/37/38 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylicacid ethyl ester;7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylicacid ethyl ester;7-Chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylicacid ethyl ester;Ethyl1-(2,4-difluorophenyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate; |
Article Data | 7 |
ethyl-3,1-(2,4-difluoroanilino)-2-(2,6-dichloro-5-fluoronicotinyl) acrylate
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran for 1h; Heating; | 86.5% |
With sodium hydride In 1,4-dioxane for 1h; Ambient temperature; | |
With sodium hydride In tetrahydrofuran for 1.5h; Inert atmosphere; Reflux; | 8 g |
With sodium hydrogencarbonate In dichloromethane at 35℃; for 3h; Temperature; Solvent; Reagent/catalyst; |
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
Conditions | Yield |
---|---|
In diethyl ether; trichlorophosphate | 85% |
ethyl 2-[2-(2,4-difluorophenylamino)-5-fluoro-6-methoxynicotinoyl]acetate
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
Conditions | Yield |
---|---|
With trichlorophosphate In diethyl ether; chloroform; water; N,N-dimethyl-formamide | 72.2% |
ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) Ac2O / 1.) 130 deg C, 1 h, 2.) CH2Cl2, RT, 0.5 h 2: 86.5 percent / NaH / tetrahydrofuran / 1 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: Ac2O / 15 h / 130 °C 2: ethanol / 1 h / Ambient temperature 3: NaH / dioxane / 1 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1.1: acetic anhydride / 1 h / 130 °C 1.2: 1 h 2.1: sodium hydride / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux View Scheme |
2,6-dichloro-5-fluoro-3-nicotinoyl chloride
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) n-BuLi, biquinoline / 1.) THF, hexane, from -30 deg C to -5 deg C, 2.) THF, hexane, RT, 1 h 2: 1.) Ac2O / 1.) 130 deg C, 1 h, 2.) CH2Cl2, RT, 0.5 h 3: 86.5 percent / NaH / tetrahydrofuran / 1 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 2.) p-TsOH*H2O / 1.) ether, RT, 2 h, 2.) H2O, reflux, 2.5 h 2: Ac2O / 15 h / 130 °C 3: ethanol / 1 h / Ambient temperature 4: NaH / dioxane / 1 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1.1: 2,2'-biquinoline; n-butyllithium / tetrahydrofuran; hexane / 1 h / -50 - 20 °C 2.1: acetic anhydride / 1 h / 130 °C 2.2: 1 h 3.1: sodium hydride / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux View Scheme |
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / 2 h / 80 °C 2: 1.) n-BuLi, biquinoline / 1.) THF, hexane, from -30 deg C to -5 deg C, 2.) THF, hexane, RT, 1 h 3: 1.) Ac2O / 1.) 130 deg C, 1 h, 2.) CH2Cl2, RT, 0.5 h 4: 86.5 percent / NaH / tetrahydrofuran / 1 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: PCl5 / 0.13 h / 100 °C 2: 2.) p-TsOH*H2O / 1.) ether, RT, 2 h, 2.) H2O, reflux, 2.5 h 3: Ac2O / 15 h / 130 °C 4: ethanol / 1 h / Ambient temperature 5: NaH / dioxane / 1 h / Ambient temperature View Scheme | |
Multi-step reaction with 4 steps 1.1: thionyl chloride / 2.5 h / 85 °C 2.1: 2,2'-biquinoline; n-butyllithium / tetrahydrofuran; hexane / 1 h / -50 - 20 °C 3.1: acetic anhydride / 1 h / 130 °C 3.2: 1 h 4.1: sodium hydride / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux View Scheme |
ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 73.2 percent / trifluoroacetic acid, 7.5 N aq. HCl / 24 h / Heating 2: thionyl chloride / 2 h / 80 °C 3: 1.) n-BuLi, biquinoline / 1.) THF, hexane, from -30 deg C to -5 deg C, 2.) THF, hexane, RT, 1 h 4: 1.) Ac2O / 1.) 130 deg C, 1 h, 2.) CH2Cl2, RT, 0.5 h 5: 86.5 percent / NaH / tetrahydrofuran / 1 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1.1: trifluoroacetic acid; hydrogenchloride / water / 26 h / Reflux 2.1: thionyl chloride / 2.5 h / 85 °C 3.1: 2,2'-biquinoline; n-butyllithium / tetrahydrofuran; hexane / 1 h / -50 - 20 °C 4.1: acetic anhydride / 1 h / 130 °C 4.2: 1 h 5.1: sodium hydride / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux View Scheme |
2,4-difluorophenylamine
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol / 1 h / Ambient temperature 2: NaH / dioxane / 1 h / Ambient temperature View Scheme |
2,6-dichloro-α-(ethoxymethylene)-5-fluoro-β-oxo-3-pyridinepropanoic acid ethyl ester
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol / 1 h / Ambient temperature 2: NaH / dioxane / 1 h / Ambient temperature View Scheme |
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
tert-butyl (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylcarbamate
7-([1α,5α,6α]-6-tert-Butoxycarbonylamino-3-azabicyclo[3.1.0]hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid,ethyl ester
Conditions | Yield |
---|---|
With triethylamine In methanol for 1h; Substitution; Heating; | 99% |
The IUPAC name of Ethyl 1-(2,4-difluorophenyl)-7-chloro-6-fluoro-4-oxopyridino[2,3-b]pyridine-3-carboxylate is ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate. With the CAS registry number 100491-29-0, it is also named as 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester. It is almost white powder which should be sealed in the container and stored in the cool and dry place.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 1.83; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.826; (4)ACD/LogD (pH 7.4): 1.826; (5)ACD/BCF (pH 5.5): 14.373; (6)ACD/BCF (pH 7.4): 14.373; (7)ACD/KOC (pH 5.5): 234.529; (8)ACD/KOC (pH 7.4): 234.529; (9)#H bond acceptors: 5; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.589; (13)Molar Refractivity: 84.719 cm3; (14)Molar Volume: 251.215 cm3; (15)Polarizability: 33.585×10-24 cm3; (16)Surface Tension: 54.381 dyne/cm; (17)Enthalpy of Vaporization: 77.155 kJ/mol; (18)Vapour Pressure: 0 mmHg at 25°C; (19)Rotatable Bond Count: 4; (20)Exact Mass: 382.033205; (21)MonoIsotopic Mass: 382.033205; (22)Topological Polar Surface Area: 59.5; (23)Heavy Atom Count: 26.
Preparation of Ethyl 1-(2,4-difluorophenyl)-7-chloro-6-fluoro-4-oxopyridino[2,3-b]pyridine-3-carboxylate: It can be obtained by 2-(2,6-dichloro-5-fluoro-pyridine-3-carbonyl)-3-(2,4-difluoro-phenylamino)-acrylic acid ethyl ester. This reaction needs reagent NaH and solvent dioxane at ambient temperature. The reaction time is 1 hours.
Uses of Ethyl 1-(2,4-difluorophenyl)-7-chloro-6-fluoro-4-oxopyridino[2,3-b]pyridine-3-carboxylate: It can react with piperazine to get 1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester. This reaction needs reagent pyridine at ambient temperature. The reaction time is 3 hours. The yield is 81.4%.
When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable gloves and eye/face protection.
People can use the following data to convert to the molecule structure.
1. SMILES:CCOC(=O)c1cn(c2c(c1=O)cc(c(n2)Cl)F)c3ccc(cc3F)F
2. InChI:InChI=1/C17H10ClF3N2O3/c1-2-26-17(25)10-7-23(13-4-3-8(19)5-11(13)20)16-9(14(10)24)6-12(21)15(18)22-16/h3-7H,2H2,1H3
3. InChIKey:JLSXYCZRMYCIMY-UHFFFAOYAK