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Cas Database |
| Name |
Ethyl 3,4-dihydroxybenzoate |
EINECS | 223-529-0 |
| CAS No. | 3943-89-3 | Density | 1.294 g/cm3 |
| PSA | 66.76000 | LogP | 1.27450 |
| Solubility | Insoluble in water. Soluble in ethanol. | Melting Point |
132-134 °C(lit.) |
| Formula | C9H10O4 | Boiling Point | 358.1 °C at 760 mmHg |
| Molecular Weight | 182.176 | Flash Point | 147 °C |
| Transport Information | N/A | Appearance | pale yellow to beige crystalline powder |
| Safety | 26-36-37/39 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
Protocatechuicacid, ethyl ester (7CI,8CI);3,4-Dihydroxybenzoic acid ethyl ester;Ethyl protocatechuate;NSC 619681;NSC 86130; |
Article Data | 34 |
Ethyl 3,4-dihydroxybenzoate Synthetic route
| Conditions | Yield |
|---|---|
| With sulfuric acid Heating; | 99% |
| With sulfuric acid at 50℃; for 3h; | 98% |
| With sulfuric acid | 98% |
- 3943-89-3
Ethyl protocatechuate
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal at 20℃; for 3h; | 96% |
| Conditions | Yield |
|---|---|
| With aluminium(III) iodide; N,N-dimethyl-formamide dimethyl acetal In acetonitrile at 80℃; for 18h; Reagent/catalyst; | 94% |
| With aluminium(III) iodide; N,N-dimethyl-formamide dimethyl acetal In acetonitrile at 80℃; for 18h; Reagent/catalyst; | 94% |
| With aluminium(III) iodide; ethyl acetate; diisopropyl-carbodiimide In acetonitrile at 20℃; for 2h; chemoselective reaction; | 93% |
- 3943-89-3
Ethyl protocatechuate
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal at 20℃; for 3h; | 93% |
- 3943-89-3
Ethyl protocatechuate
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal at 20℃; for 3h; | 92% |
- 20986-39-4
ethyl 3,4-dihydro-2H-benzo[b]1,4-dioxepine-7-carboxylate
- 3943-89-3
Ethyl protocatechuate
| Conditions | Yield |
|---|---|
| With aluminum (III) chloride In benzene for 1h; Reflux; | 90% |
- 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate
- 3943-89-3
Ethyl protocatechuate
| Conditions | Yield |
|---|---|
| With iodine; oxygen; dimethyl sulfoxide at 80℃; for 12h; | 84% |
| Conditions | Yield |
|---|---|
| With dihydrogen peroxide for 3h; Irradiation; | 83% |
- 1344113-41-2
C17H28O4Si
- 3943-89-3
Ethyl protocatechuate
| Conditions | Yield |
|---|---|
| Stage #1: C17H28O4Si With palladium(II) trimethylacetate; [bis(acetoxy)iodo]benzene In α,α,α-trifluorotoluene at 120℃; Inert atmosphere; Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; Stage #3: With water In tetrahydrofuran | 76% |
- 33668-25-6
ethyl 3-oxocyclohexanecarboxylate
- 3943-89-3
Ethyl protocatechuate
| Conditions | Yield |
|---|---|
| With iodine; oxygen; dimethyl sulfoxide at 80℃; for 12h; regioselective reaction; | 53% |
Ethyl 3,4-dihydroxybenzoate Chemical Properties
IUPAC Name: Ethyl 3,4-dihydroxybenzoate
Molecular Formula: C9H10O4
Molecular Weight: 182.173300 g/mol
Appearance: Pale yellow to beige crystalline powder
Density: 1.294 g/cm3
Melting Point: 131-136 °C
Boiling Point: 358.1 °C at 760 mmHg
Flash Point: 147 °C
Solubility: Ethanol
Insolubility: Water
BRN: 2097435
EINECS: 223-529-0
Synonyms of Ethyl 3,4-dihydroxy benzoate (CAS NO. 3943-89-3):
Ethyl protocatechuate ; Benzoic acid, 3,4-dihydroxy-, ethyl ester (9CI) ; Ethyl 3,4-dihydroxybenzoate
Categories of Ethyl 3,4-dihydroxy benzoate (CAS NO. 3943-89-3):
FINE Chemical & INTERMEDIATES;Aromatic Esters;Benzoic acid;Organic acids;API intermediates
Ethyl 3,4-dihydroxybenzoate Uses
Ethyl 3,4-dihydroxy benzoate , with cas registry number of 3943-89-3, is used as a food additive, pharmaceutical intermediate, etc.
Ethyl 3,4-dihydroxybenzoate Production
Ethyl 3,4-dihydroxy benzoate (CAS NO.3943-89-3) can be obtained with the 3,4-hydroxy benzoic acid and alcohol by esterification.
Ethyl 3,4-dihydroxybenzoate Safety Profile
Safety Information of Ethyl 3,4-dihydroxy benzoate (CAS NO. 3943-89-3):
Hazard Codes: Xi 
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements: 26-36-37/39
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
37/39:Wear suitable gloves and eye/face protection
WGK Germany: 3
Hazard Note: Irritant
Ethyl 3,4-dihydroxybenzoate Specification
It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, Ethyl 3,4-dihydroxy benzoate (CAS NO.3943-89-3) is not compatible with strong oxidizing agents, strong bases, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: Carbon monoxide, carbon dioxide.
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