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Cas Database |
| Name |
Ethyl bromodifluoroacetate |
EINECS | 211-567-0 |
| CAS No. | 667-27-6 | Density | 1.661 g/cm3 |
| PSA | 26.30000 | LogP | 1.53720 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C4H5BrF2O2 | Boiling Point | 114.7 °C at 760 mmHg |
| Molecular Weight | 202.983 | Flash Point | 23.2 °C |
| Transport Information | UN 2924 3/PG 2 | Appearance | clear colorless to slightly yellow liquid |
| Safety | 26-36/37/39-45-16-27 | Risk Codes | 10-34-36 |
| Molecular Structure |
|
Hazard Symbols |
 F,  Xi,  C
|
| Synonyms |
ethyl 2-bromo-2,2-difluoro-acetate;Bromodifluoroacetic acid ethyl ester;2-Bromo-2,2-difluoroacetic acid ethyl ester; |
Article Data | 19 |
Ethyl bromodifluoroacetate Synthetic route
- 101068-09-1
ethyl fluorosulfonoxydifluoroacetate
- 667-27-6
Ethyl bromodifluoroacetate
| Conditions | Yield |
|---|---|
| With sodium bromide In sulfolane at 100℃; for 12h; | 31% |
| Conditions | Yield |
|---|---|
| (i) O2, (ii) /BRN= 1718733/; Multistep reaction; |
| Conditions | Yield |
|---|---|
| (i) H2SO4, SO3, HgO, (ii) /BRN= 1718733/; Multistep reaction; |
| Conditions | Yield |
|---|---|
| (i) H2SO4, (ii) H2O; Multistep reaction; |
| Conditions | Yield |
|---|---|
| With sulfur trioxide In ethanol; water |
| Conditions | Yield |
|---|---|
| With sulfur trioxide In ethanol |
- 1246615-87-1
ethyl 2,2-difluoro-2-((4-nitrophenyl)thio)acetate
A
- 383-63-1
ethyl trifluoroacetate,
B
- 667-27-6
Ethyl bromodifluoroacetate
| Conditions | Yield |
|---|---|
| With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridinium polyhydrogenfluoride In dichloromethane at 0 - 45℃; |
- 333744-42-6
ethyl 2,2-difluoro-2-[(4-methylphenyl)thio]acetate
A
- 383-63-1
ethyl trifluoroacetate,
B
- 667-27-6
Ethyl bromodifluoroacetate
| Conditions | Yield |
|---|---|
| With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridinium polyhydrogenfluoride In dichloromethane at 0 - 45℃; |
- 380859-96-1
ethyl 2-((4-chlorophenyl)thio)-2,2-difluoroacetate
A
- 383-63-1
ethyl trifluoroacetate,
B
- 667-27-6
Ethyl bromodifluoroacetate
| Conditions | Yield |
|---|---|
| With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridinium polyhydrogenfluoride In dichloromethane at 0 - 45℃; |
- 380859-96-1
ethyl 2-((4-chlorophenyl)thio)-2,2-difluoroacetate
A
- 383-63-1
ethyl trifluoroacetate,
B
- 667-27-6
Ethyl bromodifluoroacetate
C
- 465512-60-1
ethyl 2,2-difluoro-2-(4-chlorophenylsulfinyl)acetate
| Conditions | Yield |
|---|---|
| With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridinium polyhydrogenfluoride In dichloromethane at 0 - 45℃; |
Ethyl bromodifluoroacetate Chemical Properties
Name: Ethyl bromodifluoroacetate
Synonyms: Ethylbromodifluoroacetate
IUPAC: ethyl 2-bromo-2,2-difluoroacetate
Product Categories: Pharmaceutical Intermediates;Fluoro-containing compounds;API intermediates;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;Fluoro series;C2 to C5;Carbonyl Compounds;Esters
CAS Registry Number: 667-27-6
EINECS: 211-567-0
Molecular Formula: C4H5BrF2O2
Molecular Weight: 202.98 g/mol
Molecular Structure: 
Storage temp.: Flammables area
Index of Refraction: 1.411
Surface Tension: 28.4 dyne/cm
Density: 1.661 g/cm3
Flash Point: 23.2 °C
Enthalpy of Vaporization: 35.31 kJ/mol
Boiling Point: 114.7 °C at 760 mmHg
Vapour Pressure: 19.7 mmHg at 25 °C
Ethyl bromodifluoroacetate Toxicity Data With Reference
Ethyl bromodifluoroacetate (CAS NO.667-27-6) is Harmful if swallowed, inhaled or absorbed through skin. Vapor or mist is irritating to the eyes, mucous membranes and upper respiratory tract. To the best of our knowledge, the chemical, physical and toxicological properties of Ethyl bromodifluoroacetate (CAS NO.667-27-6) have not been thoroughly investigated.
RTECS#: CAS# 667-27-6: None listed
LD50/LC50: RTECS: Not available.
Carcinogenicity: Ethyl bromodifluoroacetate - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other: The toxicological properties have not been fully investigated.
Ethyl bromodifluoroacetate Safety Profile
Hazard Codes: 
C,
F,
Xi
Risk Statements: 10-34-36
R10:Flammable.
R34:Causes burns.
R36:Irritating to eyes.
Safety Statements: 26-36/37/39-45-16-27
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S16:Keep away from sources of ignition.
S27:Take off immediately all contaminated clothing.
RIDADR: UN 2924 3/PG 2
WGK Germany: 3
Hazard Note: Irritant/Flammable
HazardClass: 3
PackingGroup: II
Wear appropriate NIOSH/MSHA- approved respirator, chemical resistant gloves, safety goggles and other protective clothing.
Do not breathe vapor.
Have safety shower and eye wash available. Use only in a chemical fume hood.
Do not get in eyes, on skin, on clothing.
Keep container closed. Store in a cool dry place.
Wash thoroughly after handling.
Ethyl bromodifluoroacetate Specification
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, ignition sources.
Incompatibilities with Other Materials Strong oxidizing agents, strong reducing agents, strong bases.
Hazardous Decomposition Products Carbon monoxide, carbon dioxide, hydrogen fluoride gas, hydrogen bromide, bromine, fluorine.
Hazardous Polymerization Has not been reported.
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