Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Ethyl hydrogen malonate

Related Products

Hot Products

Name

Ethyl hydrogen malonate

EINECS 213-992-7
CAS No. 1071-46-1 Density 1.21 g/cm3
PSA 63.60000 LogP 0.02420
Solubility Miscible with water, chloroform and other solvents. Melting Point -13°C(lit.)
Formula C5H8O4 Boiling Point 237.2 °C at 760 mmHg
Molecular Weight 132.116 Flash Point 100.8 °C
Transport Information N/A Appearance COA
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 1071-46-1 (Ethyl hydrogen malonate) Hazard Symbols IrritantXi
Synonyms

Malonicacid, ethyl ester (6CI,7CI);Malonic acid, monoethyl ester (8CI);Propanedioicacid, monoethyl ester (9CI);(Ethoxycarbonyl)acetic acid;3-Ethoxy-3-oxopropanoic acid;Propanedioic acid,1-ethyl ester;Monoethyl hydrogen malonate;Monoethyl malonate;

Article Data 87

Ethyl hydrogen malonate Synthetic route

6148-64-7

ethyl potassium malonate

1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With hydrogenchloride In water at 5℃; for 1h;100%
With hydrogenchloride In water at 0℃; for 0.666667h;99%
With hydrogenchloride In water Inert atmosphere; Cooling with ice;91%
105-53-3

diethyl malonate

1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 25℃; for 1h;94%
With potassium hydroxide In tetrahydrofuran at 0℃; for 1h;90%
Stage #1: diethyl malonate With potassium hydroxide; water In tetrahydrofuran at 0℃; for 1h;
Stage #2: With hydrogenchloride; water In tetrahydrofuran at 0℃; Product distribution / selectivity;
90%
105-56-6

ethyl 2-cyanoacetate

1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With potassium phosphate buffer; nitrilase from Alcaligenes faecalis ATCC8750 at 30℃; for 7h; pH=7.3;94%
With benzene-1,2-dicarboxylic acid at 250℃; under 7600 Torr; for 0.25h; microwave irradiation;53%
With benzene-1,2-dicarboxylic acid at 240℃; under 3040 Torr; for 1h;10%
With copper(II) sulfate at 240℃; for 1h;9%
64-17-5

ethanol

141-82-2

malonic acid

1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With boric acid Heating;80%
With sulfuric acid
With sulfuric acid In acetone for 168h;
With boric acid for 18h; Reflux;
at 80℃;
105-53-3

diethyl malonate

A

141-82-2

malonic acid

B

1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
Stage #1: diethyl malonate With water; potassium hydroxide In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: In tetrahydrofuran; water Acidic conditions;
A 8.3%
B 76.9%
Stage #1: diethyl malonate With water; potassium hydroxide at 0℃; for 6h;
Stage #2: Acidic aq. solution;
A 36.6%
B 35.6%
141-82-2

malonic acid

141-78-6

ethyl acetate

1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With iron(III) perchlorate for 2h; Ambient temperature;76%
7597-56-0

ethyl malonamate

A

60-35-5

acetamide

B

141-82-2

malonic acid

C

1071-46-1

hydrogen ethyl malonate

D

64-19-7

acetic acid

Conditions
ConditionsYield
With phthalic anhydride at 240 - 250℃; under 3040 Torr; for 1h; Hydrolysis;A n/a
B n/a
C 53%
D n/a
201230-82-2

carbon monoxide

623-48-3

ethyl iodoacetae

1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With dmap; bis-triphenylphosphine-palladium(II) chloride; pyrrole; triethylamine In water; toluene UV-irradiation; Autoclave;52%

malonic acid ethyl ester 2-thioxo-2H-pyridin-1-yl ester

A

28856-92-0

(Ethoxycarbonyl)methyl 2-pyridyl sulfide

B

2127-03-9

2,2'-dipyridyldisulphide

C

1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
In benzene photolysis; Irradiation;A 48%
B 3%
C 17%
124-38-9

carbon dioxide

105-36-2

ethyl bromoacetate

1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With tetraethylammonium chloride; silver; magnesium In acetonitrile at 0℃; under 760.051 Torr; Electrolysis;38%

Ethyl hydrogen malonate Chemical Properties

Molecule structure of Ethyl hydrogen malonate (CAS NO.1071-46-1):

IUPAC Name: 3-Ethoxy-3-oxopropanoic acid 
Molecular Weight: 132.11462 g/mol
Molecular Formula: C5H8O4 
Density: 1.21 g/cm3 
Boiling Point: 237.2 °C at 760 mmHg 
Flash Point: 100.8 °C
Index of Refraction: 1.436
Molar Refractivity: 28.55 cm3
Molar Volume: 109.1 cm3
Surface Tension: 41.8 dyne/cm 
Enthalpy of Vaporization: 52.21 kJ/mol
Vapour Pressure: 0.0155 mmHg at 25 °C
XLogP3: 0.3
H-Bond Donor: 1
H-Bond Acceptor: 4
Rotatable Bond Count: 4
Exact Mass: 132.042259
MonoIsotopic Mass: 132.042259
Topological Polar Surface Area: 63.6
Heavy Atom Count: 9
Canonical SMILES: CCOC(=O)CC(=O)O
InChI: InChI=1S/C5H8O4/c1-2-9-5(8)3-4(6)7/h2-3H2,1H3,(H,6,7)
InChIKey: HGINADPHJQTSKN-UHFFFAOYSA-N
EINECS: 213-992-7
Product Categories: Small molecule;API intermediates;C2 to C5;Carbonyl Compounds;Esters

Ethyl hydrogen malonate Uses

 Ethyl hydrogen malonate (CAS NO.1071-46-1) is used as pharmaceutical intermediates.

Ethyl hydrogen malonate Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
WGK Germany: 3

Ethyl hydrogen malonate Specification

 Ethyl hydrogen malonate (CAS NO.1071-46-1) is also named as (Ethoxycarbonyl)acetic acid ; 3-Ethoxy-3-oxopropansäure ; Acide 3-éthoxy-3-oxopropanoïque ; Malonic acid ethyl ester ; Monoethyl hydrogen malonate ; propanedioic acid, monoethyl ester .

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1071-46-1