Ethyl salicylate Synthetic route
Ethyl salicylate Chemical Properties
Structure of Ethyl salicylate (CAS NO.118-61-6):
Molecular Formula: C9H10O3
Molar mass: 166.17 g/mol
EINECS: 204-265-5
Density: 1.168 g/cm3
Flash Point: 93.8 °C
Index of Refraction: 1.538
Boiling Point: 234.4 °C at 760 mmHg
Vapour Pressure: 0.0348 mmHg at 25°C
Melting point: 1 °C(lit.)
Appearance: Clear colourless to pale yellow liquid
Product categories: Aromatic Esters ; Pharmaceutical Intermediates ; Heterocyclic Compounds
XLogP3-AA: 3
H-Bond Donor: 1
H-Bond Acceptor: 3
Systematic Name: Ethyl 2-hydroxybenzoate
SMILES: O=C(OCC)c1ccccc1O
InChI: InChI=1/C9H10O3/c1-2-12-9(11)7-5-3-4-6-8(7)10/h3-6,10H,2H2,1H3
InChIKey: GYCKQBWUSACYIF-UHFFFAOYAH
Std. InChI: InChI=1S/C9H10O3/c1-2-12-9(11)7-5-3-4-6-8(7)10/h3-6,10H,2H2,1H3
Std. InChIKey: GYCKQBWUSACYIF-UHFFFAOYSA-N
Ethyl salicylate Uses
Ethyl salicylate (CAS NO.118-61-6) is not used for the modulation daily soap flavor, but also used in the pharmaceutical.
Ethyl salicylate Toxicity Data With Reference
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
guinea pig | LDLo | oral | 1400mg/kg (1400mg/kg) | | Food and Cosmetics Toxicology. Vol. 16, Pg. 751, 1978. |
guinea pig | LDLo | subcutaneous | 1500mg/kg (1500mg/kg) | | American Journal of Physiology. Vol. 13, Pg. 331, 1905. |
rat | LD50 | oral | 1320mg/kg (1320mg/kg) | | Food and Cosmetics Toxicology. Vol. 16, Pg. 751, 1978. |
Ethyl salicylate Consensus Reports
Reported in EPA TSCA Inventory.
Ethyl salicylate Safety Profile
Moderately toxic by ingestion and subcutaneous routes. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.
Hazard Codes of Ethyl salicylate (CAS NO.118-61-6): Xn,Xi
Risk Statements:
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
Ethyl salicylate Specification
Ethyl salicylate (CAS NO.118-61-6) also can be called Salicylic acid, ethyl ester ; Ethyl 2-hydroxybenzoate ; Ethyl o-hydroxybenzoate and benzoic acid, 2-hydroxy-, ethyl ester .It is hazardous,so the first aid measures and others should be known.Such as: When on the skin: should flush skin with plenty of water immediatelyfor at least 15 minutes while removing contaminated clothing.Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.While ,it's Inhaled: Remove from exposure and move to fresh air immediately.Then you have the ingesting of the product : Do not induce vomiting.If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
In addition, It can be stable under normal temperature and pressure conditions.It is not compatible with strong oxidizing agents, strong bases, and you must not take it with light, strong oxidants and incompatible materials.And also prevent it to broken down into hazardous decomposition products: irritating and toxic fumes and gases, carbon dioxide, carbon monoxide.