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Cas Database |
| Name |
Etofenamate |
EINECS | N/A |
| CAS No. | 30544-47-9 | Density | 1.317g/cm3 |
| PSA | 67.79000 | LogP | 3.68770 |
| Solubility | N/A | Melting Point |
25°C |
| Formula | C18H18 F3 N O4 | Boiling Point | 451.1°C at 760 mmHg |
| Molecular Weight | 369.34 | Flash Point | 226.6°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous routes. Experimental teratogenic and reproductive effects. Used as an anti-inflammatory agent. When heated to decomposition it emits very toxic fumes of F− and NOx. See also FLUORIDES. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Anthranilicacid, N-(a,a,a-trifluoro-m-tolyl)-, 2-(2-hydroxyethoxy)ethyl ester (8CI);2-(2-Hydroxyethoxy)ethyl flufenamate;2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid 2-(2-hydroxyethoxy)ethylester; B 577; Bay-d 1107; Bayrogel; Etofenamate; Glasel; Reumon; Rheumon;Rheumon gel; TV 485; Traumon Gel; WHR 5020 |
Article Data | 4 |
Etofenamate Synthetic route
- 64352-85-8
2-(3-Trifluoromethyl-phenylamino)-benzoic acid 2-(2-benzyloxy-ethoxy)-ethyl ester
- 30544-47-9
etofenamate
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In methanol; ethyl acetate |
- 64661-77-4
C43H40F6N2O8
- 30544-47-9
etofenamate
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In methanol |
- 628-89-7
2-(2-Chloroethoxy)ethanol
- 30544-47-9
etofenamate
| Conditions | Yield |
|---|---|
| With potassium carbonate In N,N,N,N,N,N-hexamethylphosphoric triamide |
- 30544-47-9
etofenamate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: hexamethylphosphoric acid triamide 2: H2 / Pd-C / methanol View Scheme |
Etofenamate Chemical Properties
IUPAC Name: 2-(2-Hydroxyethoxy)ethyl 2-[3-(trifluoromethyl)anilino]benzoate
Molecular Formula:C18H18F3NO4
Molecular Weight: 369.335 g/mol
EINECS: 250-231-8
Boiling Point:130–135°C
Apperance: oil
Partition Coefficient: Log P 4.99 (calc).
Structure of Etofenamate (CAS NO. 30544-47-9): 
Product Category : Fluorides.
Etofenamate Uses
Etofenamate(CAS NO. 30544-47-9) is a non-steroidal anti-inflammatory drug (NSAID). NSAIDs relieve pain and reduce the inflammation and fever produced by the body's immune system. Etofenamate has been successfully used for a number a years to treat patients with acute or chronic rheumatic diseases.
Etofenamate Toxicity Data With Reference
| 1. | orl-rat LD50:292 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 27 (1977),1333. | ||
| 2. | ipr-rat LD50:373 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 27 (1977),1333. | ||
| 3. | scu-rat LD50:568 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 27 (1977),1333. | ||
| 4. | ivn-rat LD50:139 mg/kg | YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225. | ||
| 5. | orl-mus LD50:743 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 27 (1977),1333. | ||
| 6. | scu-mus LD50:1897 mg/kg | YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225. | ||
| 7. | ivn-mus LD50:75 mg/kg | YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225. | ||
| 8. | scu-rbt LD50:1532 mg/kg | YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225. |
Etofenamate Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous routes. Experimental teratogenic and reproductive effects. Used as an anti-inflammatory agent. When heated to decomposition it emits very toxic fumes of F− and NOx. See also FLUORIDES.
Etofenamate Analytical Methods
Uv max (methanol): 286 (E1%1cm 423). nD25 1.564.
Etofenamate Specification
Etofenamate its cas register number is 30544-47-9. It also can be called n-(Alpha,alpha,alpha-trifluoro-m-tolyl)-anthranilic acid ; 2-(2-hydroxyethoxy) ; 2-(2-Hydroxyethoxy)ethyl 2-[ [3-(trifluoromethyl)phenyl]amino]benzoate ; Rheumon ; TV-485 .
It is hazardous. Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous routes. When Etofenamate (CAS NO. 30544-47-9) is heated to decomposition, it emits very toxic fumes of F− and NOx. So keep the prodct in cool place, and put it away from fire.
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