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FENBENDAZOLE

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Name

FENBENDAZOLE

EINECS 256-145-7
CAS No. 43210-67-9 Density 1.4 g/cm3
PSA 92.31000 LogP 3.96540
Solubility Insoluble in water Melting Point 233 °C
Formula C15H13N3O2S Boiling Point N/A
Molecular Weight 299.353 Flash Point N/A
Transport Information N/A Appearance Off-white solid
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 43210-67-9 (Fenbendazole) Hazard Symbols IrritantXi
Synonyms

Carbamicacid, [5-(phenylthio)-1H-benzimidazol-2-yl]-, methyl ester (9CI);2-(Methoxycarbonylamino)-5-(phenylthio)benzimidazole;Axilur;Fenbendazol;Fenbion;HOE 881;Methyl5-(phenylthio)-2-benzimidazolecarbamate;Methyl[5-(phenylthio)-1H-benzimidazol-2-yl]carbamate;Panacur;Safe-Guard;

Article Data 13

FENBENDAZOLE Synthetic route

43156-48-5

1,2-diamino-4-phenylthiobenzene

867-44-7

S-Methylisothiourea sulfate

79-22-1

methyl chloroformate

43210-67-9

Fenbendazole

Conditions
ConditionsYield
Stage #1: S-Methylisothiourea sulfate; methyl chloroformate With sodium hydroxide In water at 3 - 6℃; for 0.666667h;
Stage #2: 1,2-diamino-4-phenylthiobenzene With acetic acid In ethanol; water at 95℃; for 24h;
88%
43156-47-4

2-nitro-5-phenylthioaniline

43210-67-9

Fenbendazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr
2.1: NaOH / H2O / 0.67 h / 3 - 6 °C
2.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C
View Scheme
1635-61-6

5-chloro-2-nitroaniline

43210-67-9

Fenbendazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: K2CO3 / dimethylformamide / 6 h / Heating
2.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr
3.1: NaOH / H2O / 0.67 h / 3 - 6 °C
3.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C
View Scheme
108-98-5

thiophenol

43210-67-9

Fenbendazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: K2CO3 / dimethylformamide / 6 h / Heating
2.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr
3.1: NaOH / H2O / 0.67 h / 3 - 6 °C
3.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C
View Scheme
(5-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; (6-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; mixture of

(5-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; (6-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; mixture of

43210-67-9

Fenbendazole

Conditions
ConditionsYield
With chicken alkaline phosphatase In water at 39℃; pH=6.5 - 9.0; Enzyme kinetics;
With porcine alkaline phosphatase In water at 37℃; pH=6.5 - 9.0; Enzyme kinetics;
Conditions
ConditionsYield
With dihydrogen peroxide; sodium sulfite In methanol; water98.8%
With urea hydrogen peroxide adduct In formic acid; water at 25 - 45℃; for 5.5h; Temperature; Concentration;98%
43210-67-9

Fenbendazole

53065-28-4

5-(phenylthio)-1H-benzo[d]imidazol-2-amine

Conditions
ConditionsYield
With potassium hydroxide In methanol; water for 48h; Heating;98%
In N,N-dimethyl-formamide for 12h; Heating;50%
541-41-3

chloroformic acid ethyl ester

43210-67-9

Fenbendazole

A

58521-88-3

2-Methoxycarbonylamino-5-phenylsulfanyl-benzoimidazole-1-carboxylic acid ethyl ester

B

58522-05-7

2-Methoxycarbonylamino-6-phenylsulfanyl-benzoimidazole-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane Ambient temperature;
79-22-1

methyl chloroformate

43210-67-9

Fenbendazole

A

58521-87-2

methyl 1-methoxycarbonyl-5-phenylthiobenzimidazole-2-carbamate

B

58522-04-6

2-Methoxycarbonylamino-6-phenylsulfanyl-benzoimidazole-1-carboxylic acid methyl ester

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane for 20h; Ambient temperature;A 12 g
B 8 g
43210-67-9

Fenbendazole

2941-64-2

Ethyl chlorothioformate

A

104663-11-8

2-Methoxycarbonylamino-5-phenylsulfanyl-benzoimidazole-1-carbothioic acid S-ethyl ester

B

104663-33-4

2-Oxo-5-phenylsulfanyl-benzoimidazole-1,3-dicarbothioic acid di-S-ethyl ester

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane Ambient temperature;

FENBENDAZOLE Chemical Properties

IUPAC:methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate
CAS:43210-67-9
The Molecular formula of Fenbendazole(43210-67-9):C15H13N3O2S
The Molecular Weight of Fenbendazole(43210-67-9):299.35
Synonyms:[5-(PHENYLTHIO)-1H-BENZIMIDAZOL-2-YL]CARBAMIC ACID, METHYL ESTER;HOE-881V;FENBENDAZOLE;METHYL 5-(PHENYLTHIO)-2-BENZIMIDAZOLECARBAMATE;SAFEGARD;PANACUR;(5-(phenylthio)-1h-benzimidazol-2-yl)-carbamicacimethylester;5-(phenylthio)-2-benzimidazolecarbamicacimethylester
EINECS:256-145-7
Density:1.4g/cm3
Melting Point:233oC
Appearance:white to yellowish powder
Product Categories:PHARMACEUTICALS;Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Veterinaries
Mol File:43210-67-9.mol
storage temp.:0-6oC

FENBENDAZOLE Uses

Fenbendazole(43210-67-9) is known as a kind of benzimidazole anthelmintics. It is regularly used to eliminate numerous gastrointestinal parasites from animals,and it is quite effective against roundworms, hookworms, whipworms, certain tapeworms and parasites called strongyles and strongyloides.

FENBENDAZOLE Toxicity Data With Reference

1.   

oth:hmn:lym 100 mg/L

   ENMUDM    Environmental Mutagenesis. 2 (1980),67.
2.   

oth:hmn:leu 1 mg/L

   THERAP    Therapie. 31 (1976),505.

FENBENDAZOLE Safety Profile

Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.

Safty informations about Fenbendazole(43210-67-9):
Hazard Codes:Xi
Risk Statements:36/37/38
 36/37/38(Irritating to eyes, respiratory system and skin)
Safety Statements:26-36
 26(In case of contact with eyes, rinse immediately with plenty of water and seek medical advice)
 36(Wear suitable protective clothing)
WGK Germany:2
RTECS:DD6520500

FENBENDAZOLE Specification

Storage:Keep tightly closed.
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