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Name |
Fenfluramine hydrochloride |
EINECS | 206-968-2 |
CAS No. | 404-82-0 | Density | N/A |
PSA | 12.03000 | LogP | 3.63680 |
Solubility | N/A | Melting Point |
1660C |
Formula | C12H17ClF3N | Boiling Point | 243.1 °C at 760 mmHg |
Molecular Weight | 267.722 | Flash Point | 100.8 °C |
Transport Information | N/A | Appearance | Crystalline Solid |
Safety | 7-16-36/37-45-36/37/39-22 | Risk Codes | 25-23/24/25 |
Molecular Structure | Hazard Symbols | T | |
Synonyms |
Benzeneethanamine,N-ethyl-a-methyl-3-(trifluoromethyl)-,hydrochloride (9CI);1-(m-Trifluoromethylphenyl)-2-(ethylamino)propane hydrochloride;Fenfluraminehydrochloride;HHR-965;N-Ethyl-a-methyl-m-(trifluoromethyl)phenethylaminehydrochloride;Ponderal;Ponderax;Ponderex;Pondimin;Fenfluramine hydrochloride; |
Article Data | 4 |
Fenfluramine hydrochloride is a drug that suppresses appetite by altering brain levels of serotonin, formerly used in the management of obesity. With the CAS NO.404-82-0, it is also called Phenfluoramine hydrochloride; Ponderal; Ponderax; Pondimin. And it should be stored in airtight containers.
Physical properties about Fenfluramine hydrochloride are: (1)ACD/LogP: 3.047; (2)ACD/LogD (pH 5.5): -0.04; (3)ACD/LogD (pH 7.4): 0.40; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 2.45; (8)#H bond acceptors: 1 ; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 4; (11)Flash Point: 100.8 °C ; (12)Enthalpy of Vaporization: 48.01 kJ/mol; (13)Boiling Point: 243.1 °C at 760 mmHg; (14)Vapour Pressure: 0.0327 mmHg at 25°C
Uses of Fenfluramine hydrochloride: Fenfluramine hydrochloride is used as slimming products. Apply to simple obesity. The blood drug levels reached steady state after 3-4d, resulting in efficacy. It is a compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
When you are using this chemical, please be cautious about it as the following:
1. Keep container tightly closed;
2. Keep away from sources of ignition - No smoking;
3. Wear suitable protective clothing and gloves;
4. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible);
You can still convert the following datas into molecular structure:
(1)InChI=1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H;
(2)InChIKey=ZXKXJHAOUFHNAS-UHFFFAOYSA-N;
(3)Smilesc1(cccc(c1)C(F)(F)F)C[C@@H](C)NCC.Cl;
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | oral | 60mg/kg (60mg/kg) | BEHAVIORAL: REGIDITY BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR | Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971. |
child | LDLo | oral | 70mg/kg (70mg/kg) | CARDIAC: OTHER CHANGES | Clinical Toxicology. Vol. 14, Pg. 97, 1979. |
dog | LD50 | intravenous | 23mg/kg (23mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Toxicology and Applied Pharmacology. Vol. 14, Pg. 182, 1969. |
dog | LD50 | oral | 100mg/kg (100mg/kg) | BEHAVIORAL: REGIDITY BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR | Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971. |
guinea pig | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | BEHAVIORAL: REGIDITY BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR | Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971. |
human | TDLo | oral | 7mg/kg (7mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | British Medical Journal. Vol. 1, Pg. 740, 1967. |
mouse | LD50 | intraperitoneal | 92mg/kg (92mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: FOOD INTAKE (ANIMAL) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1561, 1978. |
mouse | LD50 | intravenous | 90mg/kg (90mg/kg) | BEHAVIORAL: REGIDITY BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR | Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971. |
mouse | LD50 | oral | 170mg/kg (170mg/kg) | Therapie. Vol. 20, Pg. 297, 1965. | |
rabbit | LD50 | oral | 50mg/kg (50mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY BEHAVIORAL: TREMOR | Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971. |
rat | LD50 | intraperitoneal | 90mg/kg (90mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY | Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971. |
rat | LD50 | oral | 69mg/kg (69mg/kg) | BEHAVIORAL: FLUID INTAKE | Toxicology and Applied Pharmacology. Vol. 14, Pg. 182, 1969. |
women | TDLo | oral | 36mg/kg (36mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: SLEEP SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 161, 1995. |