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Name	Fluorescein chloride	EINECS	211-147-7
CAS No.	630-88-6	Density	1.56 g/cm³
PSA	35.53000	LogP	5.56140
Solubility	N/A	Melting Point	253-255 °C(lit.)
Formula	C20H10 Cl2 O3	Boiling Point	539.8ºC at 760 mmHg
Molecular Weight	369.204	Flash Point	214.3ºC
Transport Information	N/A	Appearance	white to light yellow crystalline powder.
Safety	37/39-26	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	Fluoran,3',6'-dichloro- (7CI,8CI); 3,6-Dichlorofluorescein; 3',6'-Dichlorofluoran;Fluorescein dichloride; NSC 231613	Article Data	9

Fluorescein chloride Synthetic route

: 2321-07-5
fluorescein

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
With sulfolane; thionyl chloride In N,N-dimethyl-formamide at 60 - 80℃; for 2.5h; Temperature;	90.5%
With phosphorus pentachloride at 100℃;
With thionyl chloride
With phosphorus pentachloride In chlorobenzene at 140℃; for 6h;
With phosphorus pentachloride In chlorobenzene at 140℃; for 6h;

: 108-43-0
3-monochlorophenol

: 76135-38-1
2-(4'-chloro-2'-hydroxybenzoyl)benzoic acid

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
With zinc(II) chloride at 155 - 160℃; for 12h;	76%

: 85-44-9
phthalic anhydride

: 108-43-0
3-monochlorophenol

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
With ferric hydrogen sulphate at 160℃; for 13h; neat (no solvent);	70%
With zinc(II) chloride at 185 - 190℃;

: 85-44-9
phthalic anhydride

activated aluminium: activated aluminium

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 195 - 200 °C 2: phosphorus pentachloride / 100 °C View Scheme

: 2513-33-9
2-(2,4-dihydroxybenzoyl)benzoic acid

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: beim Erhitzen ueber den Schmelzpunkt 2: phosphorus pentachloride / 100 °C View Scheme
Multi-step reaction with 2 steps 2: phosphorus pentachloride / 100 °C View Scheme

: 108-46-3
recorcinol

phenoldiazonium chloride-(4): phenoldiazonium chloride-(4)

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 195 - 200 °C 2: phosphorus pentachloride / 100 °C View Scheme
Multi-step reaction with 2 steps 2: phosphorus pentachloride / 100 °C View Scheme

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 87021-19-0
3,6-dichloro-9-(carboxyphenyl)xanthen

Conditions

Conditions	Yield
With acetic acid; zinc(II) chloride for 10h; Heating;	97%

: 1126-78-9
N-(n-butyl)aniline

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 915038-78-7
3'-N-butylanilino-6'-chlorofluoran

Conditions

Conditions	Yield
Stage #1: N-(n-butyl)aniline; 3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one; aluminum (III) chloride In sulfolane at 60 - 80℃; for 1.08333h; Stage #2: With hydrogenchloride; water In sulfolane at 0℃;	96%

: 578-54-1
ortho-ethylaniline

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 3,6-(o-ethylaniline)fluorescein

Conditions

Conditions	Yield
With aluminum (III) chloride In N,N-dimethyl-formamide at 100 - 150℃; for 10.5h; Temperature; Reagent/catalyst;	86.2%

: 279-40-3
7-aza-bicyclo[2.2.1]heptane

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 1225568-28-4
C32H30N2O3

Conditions

Conditions	Yield
With zinc(II) oxide; zinc(II) chloride at 190℃; for 12h; high pressure reactor;	40%

Fluorescein chloride Chemical Properties

Molecular Structure:

Molecular Formula: C₂₀H₁₀Cl₂O₃
Molecular Weight: 369.1976
IUPAC Name: 3',6'-Dichlorospiro[2-benzofuran-3,9'-xanthene]-1-one
Synonyms of Fluorescein chloride (CAS NO.630-88-6): 3',6'-Dichlorofluoran ; EINECS 211-147-7 ; Fluorescein dichloride ; NSC 231613 ; 3',6'-Dichlorospiro(phthalide-3,9'-xanthene) ; Fluoran, 3',6'-dichloro- (8CI) ; Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dichloro-
CAS NO: 630-88-6
Melting point: 253-255 °C
Index of Refraction: 1.736
Molar Refractivity: 94.59 cm³
Molar Volume: 235.4 cm³
Surface Tension: 71 dyne/cm
Density: 1.56 g/cm³
Flash Point: 214.3 °C
Enthalpy of Vaporization: 81.73 kJ/mol
Boiling Point: 539.8 °C at 760 mmHg
Vapour Pressure of Fluorescein chloride (CAS NO.630-88-6): 1.01E-11 mmHg at 25°C

Fluorescein chloride Safety Profile

Hazard Codes of Fluorescein chloride (CAS NO.630-88-6): Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 37/39-26
S37/39: Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3

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