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Cas Database |
| Name |
Fluorescein disodium salt |
EINECS | 208-253-0 |
| CAS No. | 518-47-8 | Density | 1.601 g/cm3 (20ºC) |
| PSA | 81.65000 | LogP | 4.54220 |
| Solubility | water: 500 g/L (20 °C) | Melting Point |
320 °C |
| Formula | C20H10Na2O5 | Boiling Point | 662.6 °C at 760 mmHg |
| Molecular Weight | 376.276 | Flash Point | 247.1 °C |
| Transport Information | N/A | Appearance | orange powder |
| Safety | 22-24/25-37/39-26-36/37/39-27 | Risk Codes | 36-36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
Fluorescein,disodium salt (8CI);Fluorin (6CI,7CI);Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,3',6'-dihydroxy-, disodium salt (9CI);11824 Yellow;3058Uranine;5(6)-Carboxyfluorescein sodium;ABCO Uranine;Abbey Uranine;AcidYellow 73;Aizen Uranine;Basacid Yellow 226;C.I. 45350;C.I. Acid Yellow 73;C Yellow 8;D and C Yellow No. 8;C Yellow No. 8;C Yellow No. 8-307225;Dinacid FlorescineceUranine;Fluo-rectal;Fluorescein LT;Fluorescein Sodium B.P; |
Article Data | 2 |
Fluorescein disodium salt Synthetic route
- 518-47-8
fluorescein sodium salt
- 106-95-6
allyl bromide
- 145387-24-2
allyl 2-(6-(allyloxy)-3-oxo-3H-xanthen-9-yl)benzoate
| Conditions | Yield |
|---|---|
| With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 48h; | 37% |
- 518-47-8
fluorescein sodium salt
- 15086-94-9
eosin y
| Conditions | Yield |
|---|---|
| With potassium bromate; sulfuric acid; potassium bromide In water; acetone for 2h; | 1.15 g |
- 518-47-8
fluorescein sodium salt
- 1621954-04-8
C47H42O10
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: sodium iodide / N,N-dimethyl-formamide 2: dmap; dicyclohexyl-carbodiimide View Scheme |
| Conditions | Yield |
|---|---|
| With sodium iodide In N,N-dimethyl-formamide |
- 518-47-8
fluorescein sodium salt
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C View Scheme |
- 518-47-8
fluorescein sodium salt
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 3: sodium hypochlorite; sodium hydroxide / water / 3 h / 20 °C View Scheme |
- 518-47-8
fluorescein sodium salt
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 3: sodium hypochlorite; sodium hydroxide / water / 3 h / 20 °C 4: chloranil / dichloromethane / 7 h / 20 °C View Scheme |
- 518-47-8
fluorescein sodium salt
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 3: sodium hypochlorite; sodium hydroxide / water / 3 h / 20 °C 4: chloranil / dichloromethane / 7 h / 20 °C 5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C View Scheme |
- 518-47-8
fluorescein sodium salt
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 3: sodium hypochlorite; sodium hydroxide / water / 3 h / 20 °C 4: chloranil / dichloromethane / 7 h / 20 °C 5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C 6: tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid; methanol / dichloromethane / 20 °C / Inert atmosphere View Scheme |
- 518-47-8
fluorescein sodium salt
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 3: sodium hypochlorite; sodium hydroxide / water / 3 h / 20 °C 4: chloranil / dichloromethane / 7 h / 20 °C 5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C 6: tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid; methanol / dichloromethane / 20 °C / Inert atmosphere 7: trifluoroacetic acid / chloroform / 20 °C View Scheme |
Fluorescein disodium salt Chemical Properties
The Molecular Structure of Fluorescein sodium (CAS NO.518-47-8):
Empirical Formula: C20H10Na2O5
Molecular Weight: 376.2699
IUPAC Name: disodium 2-(3-oxido-6-oxoxanthen-9-yl)benzoate
Appearance: orange powder
Product Categories: Intermediates of Dyes and Pigments;Dyes and Pigments
Nominal Mass: 376 Da
Average Mass: 376.2699 Da
Monoisotopic Mass: 376.032363 Da
Flash Point: 232.6 °C
Enthalpy of Vaporization: 95.37 kJ/mol
Boiling Point: 620.8 °C at 760 mmHg
Vapour Pressure: 5.24E-16 mmHg at 25°C
Water Solubility: 500 g/L (20 ºC)
Stability: Stable
InChI
InChI=1/C20H12O5.2Na/c21-11-5-7-15-17(9-11)25-18-10-12(22)6-8-16(18)19(15)13-3-1-2-4-14(13)20(23)24;;/h1-10,21H,(H,23,24);;/q;2*+1/p-2
Smiles
c1(c2c(oc3c1ccc(c3)[O-])cc(=O)cc2)c1c(cccc1)C(=O)[O-].[Na+].[Na+]
Fluorescein disodium salt Uses
Fluorescein sodium (CAS NO.518-47-8) is used extensively as a diagnostic tool in the field of ophthalmology and optometry.
Fluorescein disodium salt Toxicity Data With Reference
| 1. | dnd-esc 15 µmol/L | MUREAV Mutation Research. 89 (1981),95. | ||
| 2. | ivn-man TDLo:14 mg/kg/10M-I:CVS AACRAT 66,283,87 | |||
| 3. | ivn-man TDLo:7142 µg/kg:EYE,GIT | AJOPAA American Journal of Ophthalmology. 103 (1987),111. | ||
| 4. | orl-rat LD50:6721 mg/kg | JOPRAJ Journal of Periodontology. 48 (1977),228. | ||
| 5. | orl-mus LD50:4738 mg/kg | JOPRAJ Journal of Periodontology. 48 (1977),228. | ||
| 6. | ipr-mus LD50:1800 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 24 (1973),37. |
Fluorescein disodium salt Consensus Reports
Reported in EPA TSCA Inventory.
Fluorescein disodium salt Safety Profile
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Human systemic effects by intravenous route: arrhythmias, eye hemorrhage, nausea or vomiting. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Na2O.
Hazard Codes: 
Xi
Risk Statements: 36-36/37/38
R36: Irritating to eyes
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 22-24/25-37/39-26-36/37/39-27
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S37/39: Wear suitable gloves and eye/face protection
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S27: Take off immediately all contaminated clothing
WGK Germany: 1
RTECS: LM5425000
F 3: Hygroscopic
HS Code: 32041200
Fluorescein disodium salt Specification
Handling and storge of Fluorescein sodium :
Handling: Wash thoroughly after handling. Use with adequate ventilation.Minimize dust generation and accumulation. Avoid ingestion and inhalation.Avoid contact with skin, eyes,and clothing. Keep container tightly closed.
Storage: Keep container closed when not in use. Store in a cool, dry,well-ventilated area away from incompatible substances. Store protected from moisture.
Fluorescein sodium (CAS NO.518-47-8) is also called as 9-(O-carboxyphenyl)-6-hydroxy-3h-xanthen-3-one,disodiumsalt ; 9’-(9H)xanthen)-3-one,3’,6’-dihydroxy-spiro(isobenzofuran-1(3hdisodiums) ; 9’-[9H]xanthen]-3-one,3’,6’-dihydroxy-spiro[isobenzofuran-1(3hdisodiumsal ; 9-O-carboxyphenyl-6-hydroxy-3 isoxanthone,disodiumsalt ; Abcoluraninepowders&liquids ; Aizenuranine .
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