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Cas Database |
| Name |
Flutrimazole |
EINECS | N/A |
| CAS No. | 119006-77-8 | Density | 1.15 g/cm3 |
| PSA | 17.82000 | LogP | 5.00150 |
| Solubility | N/A | Melting Point |
161-166 °C |
| Formula | C22H16F2N2 | Boiling Point | 457.1 °C at 760 mmHg |
| Molecular Weight | 346.379 | Flash Point | 230.3 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole;UR 4056; |
Article Data | 3 |
Flutrimazole Synthetic route
- 288-32-4
1H-imidazole
- 128092-75-1
(2-Fluorophenyl)(4-fluorophenyll)phenylchloromethane
- 119006-77-8
flutrimazole
| Conditions | Yield |
|---|---|
| With triethylamine In acetonitrile for 3h; Heating; Yield given; |
- 342-24-5
o-fluorobenzophenone
- 119006-77-8
flutrimazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 1.) magnesium / 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 30 min, 2.) reflux, 2.5 h 2: thionyl chloride / 4 h / Heating 3: triethylamine / acetonitrile / 3 h / Heating View Scheme |
- 128092-72-8
(2-fluorophenyl)-(4-fluorophenyl)phenylmethanol
- 119006-77-8
flutrimazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: thionyl chloride / 4 h / Heating 2: triethylamine / acetonitrile / 3 h / Heating View Scheme |
- 460-00-4
1-Bromo-4-fluorobenzene
- 119006-77-8
flutrimazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 1.) magnesium / 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 30 min, 2.) reflux, 2.5 h 2: thionyl chloride / 4 h / Heating 3: triethylamine / acetonitrile / 3 h / Heating View Scheme |
Flutrimazole Chemical Properties
Molecular Formula: C22H16F2N2
Molecular Weight: 346.373 g/mol.
Index of Refraction: 1.59
Density: 1.15 g/cm3
Flash Point: 230.3 °C
Enthalpy of Vaporization: 68.97 kJ/mol
Boiling Point: 457.1 °C at 760 mmHg
Vapour Pressure: 4.16E-08 mmHg at 25 °C
Melting point: 161-166 °C
Structure of Flutrimazole (CAS NO.119006-77-8):
IUPAC Name: 1-[(2-Fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole
Product Category of Flutrimazole (CAS NO.119006-77-8): Flutrimazole
Flutrimazole Uses
Flutrimazole(CAS NO.119006-77-8) is used for the topical treatment of superficial mycoses of the skin, such as tinea in all its forms: tinea pedis (athlete's foot), tinea cruris, tinea corporis, tinea faciei et barbae and tinea inguinalis, caused by Trichophyton, Microsporum and by Epidermophyton floccosum. It is also indicated for the treatment of pityriasis versicolor caused by Malassezia furfur, also known as Pityrosporum ovale.
Flutrimazole Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | > 2gm/kg (2000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992. |
| mouse | LD50 | oral | > 1gm/kg (1000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992. |
| rat | LD50 | intraperitoneal | 1079mg/kg (1079mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992. |
| rat | LD50 | oral | 808mg/kg (808mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992. |
Flutrimazole Safety Profile
Flutrimazole (CAS NO.119006-77-8) may cause burning, irritation, pruritus and erythema in the treated zone. It shows a very low acute toxicity. Its topical administration does not cause sensitization and has no potential for inducing phototoxicity or photosensitivity.
Flutrimazole Specification
Flutrimazole , its cas register number is 119006-77-8. It also can be called 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole ; Micetal ; and Flusporan . It is a wide spectrum antifungal drug, and is practically insoluble in water, freely soluble in tetrahydrofuran and soluble in methanol. It interferes with the synthesis of ergosterol by inhibiting the activity of the enzyme lanosterol-14-demethylase.
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