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Cas Database |
| Name |
Fmoc-L-Methionine |
EINECS | 276-258-5 |
| CAS No. | 71989-28-1 | Density | 1.282 g/cm3 |
| PSA | 100.93000 | LogP | 4.12230 |
| Solubility | N/A | Melting Point |
121-123 °C(lit.) |
| Formula | C20H21NO4S | Boiling Point | 614.6 °C at 760 mmHg |
| Molecular Weight | 371.457 | Flash Point | 325.5 °C |
| Transport Information | N/A | Appearance | white to light yellow crystal powder |
| Safety | 22-24/25-36/37/39-27-26 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
L-Methionine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-;(S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]-4-methylsulfanylbutanoicacid;(S)-N-Fmoc-methionine;L-Fmoc-Methionine;N-(9-Fluorenylmethoxycarbonyl)-L-methionine;N-Fluorenylmethoxycarbonyl-L-methionine;NSC 334292; |
Article Data | 18 |
Fmoc-L-Methionine Synthetic route
- 500872-34-4
2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanyl-butyric acid methyl ester
- 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
| Conditions | Yield |
|---|---|
| With aluminium trichloride; N,N-dimethyl-aniline In dichloromethane | 98% |
- 63-68-3
L-methionine
- 88744-04-1
(9-fluorenyl)methyl pentafluorophenyl carbonate
- 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
| Conditions | Yield |
|---|---|
| With sodium hydrogencarbonate In water; acetone Ambient temperature; | 84% |
- 63-68-3
L-methionine
- 1131148-55-4
1-[(9-fluorenylmethyloxycarbonyl)]benzotriazole
- 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
| Conditions | Yield |
|---|---|
| With triethylamine In water; acetonitrile at 20℃; for 2h; | 84% |
- 63-68-3
L-methionine
- 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
| Conditions | Yield |
|---|---|
| With triethylamine In water Ambient temperature; | 80% |
- 63-68-3
L-methionine
- 28920-43-6
(fluorenylmethoxy)carbonyl chloride
- 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
| Conditions | Yield |
|---|---|
| Stage #1: L-methionine With chloro-trimethyl-silane In dichloromethane for 1h; Inert atmosphere; Reflux; Stage #2: (fluorenylmethoxy)carbonyl chloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 5 - 20℃; for 1.5h; | 80% |
| In acetonitrile at 20℃; for 0.25h; pH=9.2; aq. borate buffer; | |
| Stage #1: L-methionine With sodium carbonate In 1,4-dioxane; water Cooling with ice; Stage #2: (fluorenylmethoxy)carbonyl chloride In 1,4-dioxane; water at 20℃; for 5h; |
- 63-68-3
L-methionine
- 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
- 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
| Conditions | Yield |
|---|---|
| With sodium hydrogencarbonate In N,N-dimethyl-formamide at 50℃; | 78% |
| Stage #1: L-methionine With N-cyclohexyl-cyclohexanamine In acetone at 20℃; Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide With sodium carbonate In water; acetonitrile at 0 - 20℃; pH=8; Stage #3: With potassium hydrogensulfate In water; acetonitrile pH=2 - 3; | 61% |
| With sodium hydrogencarbonate In water; N,N-dimethyl-formamide at 0 - 20℃; for 2h; |
- 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
| Conditions | Yield |
|---|---|
| With methanol In dichloromethane for 0.5h; Ambient temperature; Yield given; |
- 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
| Conditions | Yield |
|---|---|
| With magnesium; acetic acid In methanol; N,N-dimethyl-formamide at 20℃; for 75h; |
- 63-68-3
L-methionine
- 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: CH2Cl2 / 1 h / Heating 2: CH2Cl2 / 72 h / Ambient temperature 3: MeOH / CH2Cl2 / 0.5 h / Ambient temperature View Scheme |
- 5269-64-7
O-(Trimethylsilyl)methionine
- 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: CH2Cl2 / 72 h / Ambient temperature 2: MeOH / CH2Cl2 / 0.5 h / Ambient temperature View Scheme |
Fmoc-L-Methionine Chemical Properties
IUPAC Name: 2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanylbutanoic acid
Molecular Formula: C20H21NO4S
Formula Weight of Fmoc-Met-OH (CAS NO.71989-28-1): 371.45 g/mol
Melting point: 121-123 °C
alpha: -29 °(c=1,DMF 24 °C)
refractive index: -29.5 °(C=1, DMF)
Surface Tension: 55.9 dyne/cm
Index of Refraction: 1.615
storage temp.: 2-8 °C
Form: Solid
Density: 1.282 g/cm3
Flash Point: 325.5 °C
Enthalpy of Vaporization: 95.88 kJ/mol
Boiling Point: 614.6 °C at 760 mmHg
Appearance: White to yellowish. (Light.)
Vapour Pressure: 5.8E-16 mmHg at 25 °C
Solubility of Fmoc-Met-OH (CAS NO.71989-28-1): Insoluble in cold water
Product Categories: Protected Amino Acids;Fluorenes, Flurenones;Amino Acids;Methionine [Met, M];Fmoc-Amino Acids and Derivatives;Amino Acids (N-Protected);Biochemistry;Fmoc-Amino Acids;Nutritional Supplements;Fmoc-Amino acid series
Following is the structure of Fmoc-Met-OH (CAS NO.71989-28-1):
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Fmoc-L-Methionine Toxicity Data With Reference
Chronic toxicity of Fmoc-Met-OH (CAS NO.71989-28-1), repeated or prolonged exposure is not known to aggravate medical condition. And it hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated.
Fmoc-L-Methionine Safety Profile
Hazard Codes :
Xi
Risk Statements : 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements : 22-24/25-36/37/39-27-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S27:Take off immediately all contaminated clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany : 3
Fmoc-L-Methionine Specification
Fmoc-Met-OH (CAS NO.71989-28-1) is stable under normal temperatures and pressures. It should avoid the condition of strong oxidants. And it is also incompatible with other materials strong oxidizing agents. Its hazardous decomposition products are carbon monoxide, oxides of nitrogen, oxides of sulfur, carbon dioxide, sodium oxide. Its hazardous polymerization has not been reported. Handling of Fmoc-Met-OH (CAS NO.71989-28-1), keep away from heat, and sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. And do not breathe dust.
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