Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D 3 analogues with a long side chain at C12 and short C17 side chains

DOI: 10.1021/jm3008272

Source and publish data:

Journal of Medicinal Chemistry p. 8642 - 8656 (2012)

Update date:2022-09-26

Topics:

Authors:

Carballa, Diego M.

Seoane, Samuel

Zacconi, Flavia

Pérez, Xenxo

Rumbo, Antonio

Alvarez-Díaz, Silvia

Larriba, María Jesús

Pérez-Fernández, Román

Mu?oz, Alberto

Maestro, Miguel

Mouri?o, Antonio

Torneiro, Mercedes

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Article abstract of DOI:10.1021/jm3008272

Structure-guided optimization was used to design new analogues of 1α,25-dihydroxyvitamin D₃ bearing the main side chain at C12 and a shorter second hydroxylated chain at C17. The new compounds 5a-c were efficiently synthesized from ketone 9 (wh

Full text of DOI:10.1021/jm3008272

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