Molecules p. 14651 - 14672 (2012)
Update date:2022-08-04
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De Castro Barbosa, Maria Leticia
Ramos, Thiago Jose Figueira
De Arantes, Ana Carolina Santos
Martins, Marco Aurelio
Silva, Patricia Machado Rodriguese
Barreiro, Eliezer J.
Lima, Lidia Moreira
In this paper we report the design, synthesis and pharmacological evaluation of a new series of phenyl sulfonamide derivatives 2a-h and 3-8 planned by structural modification on the anti-inflammatory prototype LASSBio-468 (1). Among the synthesized analogues, the tetrafluorophthalimide LASSBio-1439 (2e) stands out showing an in vitro anti-TNF-a effect similar to the standard thalidomide. The relevance of tetrafluorination of the phthalimide nucleus was also confirmed by the anti-inflammatory profile of 2e, through oral administration, in a murine model of pulmonary inflammation. The corresponding tetrafluorocarboxyamide metabolite LASSBio-1454 (15), generated from partial hydrolysis of the derivative 2e, presented a significant in vitro effect and a pronounced anti-inflammatory activity in vivo.
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