Journal of Fluorine Chemistry p. 269 - 276 (1994)
Update date:2022-08-04
Topics:
Mir, Qui-Chee
Shreeve, Jean'ne M.
1,2-Dichlorohexafluorocyclopent-1-ene and 1,2-dichlorotetrafluorocyclobut-1-ene in tetrahydrofuran solutions of 2-mercaptoethanol or 1,2-ethanedithiol and triethylamine give new mono- or di-substituted cycloolefins by displacement of one or two of the chlorine atoms at the double bond by -SCH2CH2OH or -SCH2CH2SH groups, respectively, as a function of the stoichiometry of the reactions.In several cases, the formation of spirocyclic compounds result via an intramolecular cyclization process with concomitant double-bond shift and loss of fluoride ion.Reactions of the spirocycles with nucleophiles, such as N-methylpiperazine, perfluoroglutaryl fluoride and phenylphosphonotionic chloride give rise to more highly substituted olefins and new macrofluoroheterocycles.
View MoreShanghai Harvest Chemical Ind. Co., Ltd.
Contact:021-51385350
Address:ROOM 806-807, AI LI CHEN BUILDING, No.333 JINGXIANG ROAD, PUDONG DISTRICT, 201206, SHANGHAI
website:http://www.mingchem.com/en/index
Contact:0519-85170101-802
Address:Fifth Floor,B of Beihua Buliding,520 Road of Science and Education City,Changwu middle road NO.801,Wujin District,Changzhou,Jiangsu province
Hubei Lingsheng Pharmaceuticals Co., Ltd.
Contact:+86-0710-3538058
Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
Shandong Xinhua Pharmaceutical Co.,Ltd
website:http://www.xhzy.com
Contact:+86-533-2196801
Address:1 lutai road,zhangdian dis,Zibo City
Shanghai Coupling Pharmaceutical R&D Co., Ltd.(expird)
Contact:+86 021 50106671
Address:403 Room No.4 Buiding, No. 526 Ruiqing Road, Shanghai Zhangjiang Hi-Tech Park
Doi:10.1021/ja01015a046
(1968)Doi:10.1021/ja501417g
(2014)Doi:10.1007/BF00904261
(1965)Doi:10.1016/j.tet.2014.02.066
(2014)Doi:10.1016/j.bmcl.2006.02.010
(2006)Doi:10.1271/bbb.60.506
(1996)