Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 2: Ring-substituted derivatives

Article abstract of DOI:10.1002/ardp.19973300706

A range of 18 derivatives of flavone-8-acetic acid (FAA) with substituents on the 2-phenyl group have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vitro against MAC 15A. There was no clear-cut relationship between in vitro and in vitro activity but the activity in each situation was found to be very sensitive to the precise substitution pattern with closely related isomers giving widely different activities. Some of the compounds, notably l0b,c,j, and r, were active in vitro and these require further studies in order to evaluate their potential for development.