5-alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3,4-dihydropyrimidin- 4(3H)-ones: Novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives

DOI: 10.1021/jm980260f

Source and publish data:

Journal of Medicinal Chemistry p. 619 - 627 (1999)

Update date:2022-08-04

Topics:

Authors:

Mai, Antonello

Artico, Marino

Sbardella, Gianluca

Massa, Silvio

Novellino, Ettore

Greco, Giovanni

Loi, Anna Giulia

Tramontano, Enzo

Marongiu, Maria Elena

La Colla, Paolo

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Article abstract of DOI:10.1021/jm980260f

Molecular modeling analysis of compounds belonging to the recently published series of dihydro-alkoxy-benzyl-oxopyrimidines (DABOs), such as S- DABOs and DATNOs, gave support to the design of new 2,6-disubstituted benzyl- DABO derivatives as highly potent

Full text of DOI:10.1021/jm980260f

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