Synthesis of 3-cyano-5-ethoxycarbonyl-4-isobutyl-6-methyl-3,4-dihydropyridine-2(1H)-thione by three-component condensation

DOI: 10.1007/BF02494421

Source and publish data:

Russian Chemical Bulletin p. 166 - 168 (1999)

Update date:2022-08-03

Topics:

Authors:

Krivokolysko

Dyachenko

Litvinov

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Article abstract of DOI:10.1007/BF02494421

Condensation of isovaleraldehyde with cyanothioacetamide and ethyl acetoacetate (or its enamine) gives 3-cyano-5-ethoxycarbonyl-4-isobutyl-6-methyl-3,4-dihydropyridine-2(1H)-thione. This compound was used in the synthesis of substituted 1,4-dihydropyridin-2-yl sulfides.

Full text of DOI:10.1007/BF02494421

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Product name:ethyl 5-cyano-6-{[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl}-4-isobutyl-2-methyl-1,4-dihydro-3-pyridinecarboxylate

Cas No:231935-13-0

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