Bioorganic and Medicinal Chemistry Letters p. 2043 - 2048 (1999)
Update date:2022-08-03
Topics:
Briganti, Fabrizio
Scozzafava, Andrea
Supuran, Claudiu T.
Sulfonylamido(ureido) derivatives of histamine were synthesized by an original procedure in order to obtain tight-binding activators of the zinc enzyme carbonic anhydrase (CA), exploiting the binding energy of the alkyl/arylsulfonyl moieties with amino acid residues at the entrance of the active site. In contrast to the lead molecule, histamine, the new derivatives possessed higher affinity for three different CA isozymes, as evidenced by compairing the affinity constants of these compounds for isozyme CA II.
View MoreShanghai Gsyn Chemical Co.,Ltd.
Contact:86-021-67158290
Address:86-021-67158291
Tianjin Ingenochem Technology Co.,Ltd
Contact:+86-22-23677060
Address:Hitech Green Industry Park K2-9-602, Nankai district
Contact:0086 533 2282832
Address:Zibo，Shandong
YanCheng LongShen Chemical Co.,Ltd.
Contact:+86-515-86668866
Address:No.13,Weiyi Road,Funing Aoyang Industrial Park
NINGBO PANGS CHEM INT’L CO., LTD.
Contact:+86-0574-27666801
Address:Floor 21, Building 11, Xintiandi, No. 689, Shijiroad, Ningbo, Zhejiang, China
Doi:10.1016/j.tet.2004.09.066
(2004)Doi:10.1016/j.bmcl.2003.08.050
(2003)Doi:10.1016/j.tetlet.2016.02.043
(2016)Doi:10.1016/S0040-4039(00)01709-3
(2000)Doi:10.1021/jo00972a012
(1972)Doi:10.1016/S0957-4166(00)00282-2
(2000)
