Synthesis, Structure-Activity Relationships, and Mechanism of Drug Resistance of D- and L-β-3′-Fluoro-2′,3′ -unsaturated-4′-thionucleosides as Anti-HIV Agents

Article abstract of DOI:10.1021/jm0303148

Various D- and L-2′,3′-unsaturated 3′-fluoro-4′ -thionucleosides (D- and L-3′F-4′Sd4Ns) were synthesized for the studies of structure-activity relationships. The synthesized D-2′,3′-unsaturated 3′-fluoro-4′-thionucleosides did not show any significant ant